New Advances to Overcome Resistance in Tumor Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (26 February 2024) | Viewed by 2180
Special Issue Editor
Interests: ROS; calcium; ER stress; NOX; apoptosis; cell death; natural products; phytochemicals; plant antioxidants; cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The incidence rate for various cancer types, including gastric cancer, colorectal cancer, lung cancer, ovary cancer, and breast cancer is the leading cause of death worldwide. The tumor therapeutic strategy has reduced mortality and recurrence; however, acquired resistance is still unclear. Multifaced mechanisms such as drug resistance, radioresitance, hypoxia, and growth factor deprivation are associated with a number of genes and signaling pathways that process the proliferation and cell death of cells. Reasons for resistance include autophagy, ER stress, DNA damage, endocytosis, oxidants, epithelial mesenchyme, epigenetic modification, pathway activation, cancer-related fibroblasts, extracellular matrix (ECM), exosomes, inflammatory immune cells, and so on. To overcome diverse chemoresistance, the relationship between the cell signaling pathway and resistant cancer models is important in studying the mechanism for tumor survival and cell death. Novel or famous antitumor reagents against various resistant cancer models represent a new, advanced strategy to overcome resistance on cancer therapy, but the underlying mechanisms are not fully clarified. This Special Issue of IJMS, “New Advances to Overcome Resistance in Tumor Therapy” will focus on new advanced therapeutic strategies to overcome chemoresistance in various resistant cancer models. Moreover, we will suggest progress in the understanding of various resistance cancer types and focus on therapeutic approaches to develop new treatments to overcome chemoresistance.
Dr. Tae Woo Kim
Guest Editor
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Keywords
- radiation
- hypoxia
- growth factor deprivation
- apoptosis
- autophagy
- epigenetics
- cell death
- cell survival
- resistance
