Antioxidants to Overcome Resistance in Cancer Therapy
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 20 July 2024 | Viewed by 161
Special Issue Editor
Interests: ROS; calcium; ER stress; NOX; apoptosis; cell death; natural products; phytochemicals; plant antioxidants; cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Various cancer types, including gastric, colorectal, lung, ovary, and breast cancer, are among the leading causes of death worldwide. The tumor therapeutic strategy has reduced mortality and recurrence; however, the reasons for acquired resistance are still unclear. Multifaced mechanisms like drug resistance, radioresistance, hypoxia, and growth factor deprivation are associated with a number of genes and signaling pathways that process the proliferation and death of cells. Reasons for resistance include autophagy, ER stress, DNA damage, endocytosis, oxidants, epithelial–mesenchyme transition, epigenetic modification, pathway activation, cancer-related fibroblasts, the extracellular matrix (ECM), exosomes, inflammatory immune cells, and so on. To overcome diverse chemoresistance, the relationship between antioxidants and resistant cancer models is important in the study of the mechanisms for tumor survival and cell death. Novel or candidate antioxidants against various resistant cancer models represent a new advanced strategy to overcome resistance to cancer therapy, but the underlying mechanisms are not fully clarified. This Special Issue of Antioxidants, “New antioxidants to overcome resistance in cancer therapy”, will focus on new advanced therapeutic strategies to overcome chemoresistance in various resistant cancer models. Moreover, we will encourage progress in the understanding of various resistance cancer types and focus on therapeutic approaches to develop and study new antioxidants to overcome chemoresistance.
Dr. Tae Woo Kim
Guest Editor
Manuscript Submission Information
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Keywords
- ROS
- ER stress
- NOX
- apoptosis
- cell death
- natural products
- phytochemicals
- plant antioxidants
- cancer
- drug resistance
