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Advances of Molecular Research in Reproductive Endocrinology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 July 2024 | Viewed by 1764

Special Issue Editors


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Guest Editor
Obstetrics and Gynecology, Villa Sofia Cervello Hospital, I.V.F. Public Center, University of Palermo, Palermo, Italy
Interests: endometrial cancer; obstetric and gynecological cancers; reproductive medicine; fertility preservation
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Guest Editor
Department of Obstetrics and Gynecology, Villa Sofia Cervello Hospital, IVF UNIT, University of Palermo, 90146 Palermo, Italy
Interests: reproductive endocrinology; IVF; stem cells; laparoscopy; infertility; microbioma

Special Issue Information

Dear Colleagues,

The increasing utilization of assisted reproductive technology (ART) has allowed many individuals and couples to achieve their dream of starting a family. Since the first birth that used ART over 40 years ago, there have been more than 8 million babies born with the assistance of ART. Recent data have demonstrated that many adult-onset diseases can be traced back to disruptions in early embryonic development or even during gametogenesis; consequently, the concept of the developmental origin of health and disease has been widely accepted. Research on the development, physiology and pathophysiology of reproduction is, therefore, of great importance. A growing body of literature supports the safety and efficacy of fertility preservation in certain patient populations. For example, live birth rates with cryopreserved oocytes in young women are comparable to those with fresh oocytes. Data on the efficacy of ovarian tissue cryopreservation are promising, although still relatively sparse. Additionally, the results of assisted reproductive techniques (ARTs) show evident limitations even in the pre-implantation genetic diagnosis for aneuploidies, prolonged embryo cultures, selection of embryos, etc. Furthermore, there are concerns regarding the obstetric, neonatal and adult health risks of the children conceived via ART. These powerful technologies, such as stem cells and artificial intelligence have led to numerous, important, exciting discoveries on the etiology and molecular mechanisms underlying various reproductive disorders.

This Special Issue is intended to provide an innovative and broad perspective on the research in the field of molecular reproductive biology and medicine, as well as reproductive and developmental biology.

We kindly encourage our colleagues that are involved in all fields of molecular reproduction to make contributions to this Special Issue. High-quality review articles, research articles and communications are all welcome. Potential topics include, but are not limited to, the following:

  • Reproductive biology and immunology;
  • Endometriosis,
  • Thyroid dysfunction and reproductive medicine;
  • Reproductive endocrinology;
  • Embryo development;
  • Stem cells in ART;
  • Microbioma in IVF.

Dr. Giuseppe Gullo
Prof. Dr. Antonio Perino
Prof. Dr. Gaspare Cucinella
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • embryo development
  • endometriosis
  • fertility preservation
  • artificial intelligence
  • stem cells
  • thyroid disease and reproduction
  • microbioma in ART
  • neonatal outcomes in ART
  • medical, legal and ethical aspects of infertility
  • reproductive immunology

Published Papers (1 paper)

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Review

20 pages, 963 KiB  
Review
Circulating miRNAs as a Tool for Early Diagnosis of Endometrial Cancer—Implications for the Fertility-Sparing Process: Clinical, Biological, and Legal Aspects
by Roberto Piergentili, Giuseppe Gullo, Giuseppe Basile, Caterina Gulia, Alessandro Porrello, Gaspare Cucinella, Enrico Marinelli and Simona Zaami
Int. J. Mol. Sci. 2023, 24(14), 11356; https://doi.org/10.3390/ijms241411356 - 12 Jul 2023
Cited by 9 | Viewed by 1324
Abstract
This review article explores the possibility of developing an integrated approach to the management of the different needs of endometrial cancer (EC) patients seeking to become pregnant. Life preservation of the woman, health preservation of the baby, a precocious and—as much as possible—minimally [...] Read more.
This review article explores the possibility of developing an integrated approach to the management of the different needs of endometrial cancer (EC) patients seeking to become pregnant. Life preservation of the woman, health preservation of the baby, a precocious and—as much as possible—minimally invasive characterization of the health and fertility parameters of the patient, together with the concerns regarding the obstetric, neonatal, and adult health risks of the children conceived via assisted reproductive techniques (ART) are all essential aspects of the problem to be taken into consideration, yet the possibility to harmonize such needs through a concerted and integrated approach is still very challenging. This review aims to illustrate the main features of EC and how it affects the normal physiology of pre-menopausal women. We also focus on the prospect of a miR-based, molecular evaluation of patient health status, including both EC early diagnosis and staging and, similarly, the receptivity of the woman, discussing the possible evaluation of both aspects using a single specific panel of circulating miRs in the patient, thus allowing a relatively fast, non-invasive testing with a significantly reduced margin of error. Finally, the ethical and legal/regulatory aspects of such innovative techniques require not only a risk-benefit analysis; respect for patient autonomy and equitable health care access allocation are fundamental issues as well. Full article
(This article belongs to the Special Issue Advances of Molecular Research in Reproductive Endocrinology)
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