Dear Colleagues,

Infertility is a detrimental condition that strongly affects couples, and it is expected to become more frequent worldwide. Different conditions, for both male and female partners, are responsible for infertility, accounting for structural diseases or more subtle and complex events. With this in mind, hormonal assessments play a key role in an infertility diagnosis, since their imbalance could be responsible for different outcomes. Moreover, gonadotropin administration is one of the leading medical treatments in assisted reproductive techniques (ARTs). In particular, the IVF/ICSI and IUI treatments require hormonal-controlled ovarian stimulation. In addition, new insights and proposals are provided regarding adjuvant therapies. In this scenario, we propose this Special Issue, which has the aim of moving the endocrinology field, addressing female and male infertility, forward. In particular, we aim to address two specific issues: PCOS and hypogonadotropic hypopituarism. We consider them of paramount importance, although they are often considered to be of secondary importance when dealing with IVF/ICSI procedures. Targeting this peculiar area of interest could increase both ART outcomes and the achievement of spontaneous pregnancy.

We are also grateful to receive papers with a gender approach, as well as those on the potential impacts of COVID-19 on fertility.

We would be grateful to receive original clinical and basic research articles, meta-analyses, and systematic reviews regarding the following topics:

1) PCOS and its impact on female infertility.

2) Hypogonadotropic hypopituarism diagnosis and therapy.

3) Hormone therapy and infertility.

4) Contraception.

5) Stem cells.

6) Gender medicine.

7) Medico-legal implications.

8) COVID-19 and hormones.

With the hope to have your contribution to help this field move forward,

Our best regards,

Dr. Giuseppe Gullo
Prof. Dr. Gaspare Cucinella
Dr. Giovanni Buzzaccarini
Guest Editors

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• reproductive medicine
• hormone therapy
• PCOS
• gender medicine
• contraception
• medico-legal implications
• inositol therapy
• fertility preservation
• psychological factors