Special Issue "New Advance in Endometrial Cancer & Reproductive Outcomes"

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 1443

Special Issue Editor

Obstetrics and Gynecology, Villa Sofia Cervello Hospital, I.V.F. Public Center, University of Palermo, Palermo, Italy
Interests: reproductive medicine; IVF, STEM CELLS, ART; gender medicine; dometriosis; reproductive endocrinology; reproduction biology; sterility; hysteroscopy; reproduction; fertility gynaecological ultrasound; PCOS
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Endometrial cancer (EC) is the fifth most common cancer in women worldwide. Global estimates show rising incidence rates in both developed and developing countries.

The genetic and molecular landscape of EC is becoming more and more important for both prognosis and treatment choice. The utilization and choice of ART for patients interested in fertility preservation depends on the type and stage of cancer, the treatment plan, the time available until the cancer treatment has to start, and whether the patient has a committed a partner. For patients who have a committed male partner, embryo cryopreservation has a long track record of being a very successful procedure for fertility preservation.

Fertility sparing approach for grade 1 endometrioid adenocarcinoma limited to the endometrium is feasible and can be considered in premenopausal patients with plans to conceive in the near future.

Fertility-sparing treatment predominantly involves the use of oral progestins and levonorgestrel-releasing intrauterine devices, which have been shown to be feasible and safe in women with early stage EC and minimal or no myometrial invasion.

This focused issue aims to provide an update about the current cutting of diagnosis management, treatment and outcomes of Endometrial cancer in reproductive age: fertility, from basic science to translation approach.

Topics in the focused issue:

  • Etiology and pathogenesis of endometrial cancer in fertile women
  • Biomolecular and Genetic Prognostic Factors of endometrial cancer (EC).
  • Fertility-sparing approach in EC.
  • Oocyte vitrification and fertility preservation
  • Ethical and medico-legal implication
  • Oncofertility and Reproductive Counseling
  • Artificial intelligence application in EC
  • Stem cells as therapy for EC
  • Fertility-preservation approach in in women affected by endometrial
  • Sexuality in reproductive aged women affected by EC

Dr. Giuseppe Gullo
Guest Editor

Manuscript Submission Information

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  • endometrial cancer
  • fertility preservation
  • vitrification ,oncofertility,fertility sparing
  • artificial intelligence ,stem cells
  • ethical and medico-legal implication

Published Papers (1 paper)

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13 pages, 625 KiB  
Impact of Ovarian Endometrioma and Surgery on Reproductive Outcomes: A Single-Center Spanish Cohort Study
Biomedicines 2023, 11(3), 844; https://doi.org/10.3390/biomedicines11030844 - 10 Mar 2023
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Anti-Müllerian hormone (AMH) and antral follicular count (AFC) decrease in women with ovarian endometrioma (OMA) and in vitro fertilization (IVF). In addition, these parameters drop even further when women with OMA undergo surgery. In this study, the primary aim was to compare the [...] Read more.
Anti-Müllerian hormone (AMH) and antral follicular count (AFC) decrease in women with ovarian endometrioma (OMA) and in vitro fertilization (IVF). In addition, these parameters drop even further when women with OMA undergo surgery. In this study, the primary aim was to compare the reproductive variables in IVF-treated women with and without endometriosis. The secondary aim was to explore if the reproductive variables were modified by endometrioma surgery. In this retrospective study, 244 women undergoing IVF were enrolled at the Hospital Universitario La Paz (Madrid, Spain). Women were categorized as OMA not surgically treated (OMA; n = 124), OMA with surgery (OMA + S; n = 55), and women with infertility issues not related to OMA (control; n = 65). Demographic and clinical variables, including age, body mass index (BMI), and reproductive (AMH, AFC, number of extracted oocytes, and transferred embryos) and obstetrical data (biochemical pregnancy and fetal heart rate at 6 weeks) were collected. Adjusted logistic regression models were built to evaluate reproductive and pregnancy outcomes. The models showed that women with OMA (with and without surgery) had significantly decreased levels of AMH and AFC and numbers of cycles and C + D embryos. Women with OMA + S had similar rates of pregnancy to women in the control group. However, women with OMA had lower biochemical pregnancy than controls (aOR = 0.08 [0.01; 0.50]; p-value = 0.025). OMA surgery seems to improve pregnancy outcomes, at least until 6 weeks of gestation. However, it is important to counsel the patients about surgery expectations due to the fact that endometrioma itself reduces the quality of oocytes. Full article
(This article belongs to the Special Issue New Advance in Endometrial Cancer & Reproductive Outcomes)
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