TRP Channels in Pain and Inflammation 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 April 2024 | Viewed by 517
Special Issue Editors
Interests: the capsaicin (vanilloid) receptor TRPV1; “thermoTRP” expression in cancer; TRP channels as oncotargets; TRP channels as tumor suppressors; sensory nerve-tumor interactions; oncothermia
Special Issues, Collections and Topics in MDPI journals
Interests: TRPA1; TRP ion channels; drug discovery; cardiac electrophysiology; chronic pain; neuropathic and osteoarthritis pain
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This is a continued series of the hot topic of TRP Channels for Pain, Itch and Inflammation Relief. We already have done a successful special issue that received interesting contributions and discussions (https://www.mdpi.com/journal/ijms/special_issues/TRP_Pain_Itch_Inflammation).
Transient Receptor Potential (TRP) channels are multifunctional signaling molecules with important roles in sensory perception and cellular physiology. More than two decades of intensive preclinical and clinical research supports the involvement of TRP channels in pain, itch, and neurogenic inflammation. In fact, a number of potent small molecule TRPA1 and TRPV1 antagonists have already been advanced into clinical trials for the treatment of inflammatory and neuropathic pain. Other TRP channels (e.g., TRPV2, TRPV3, TRPM2, TRPM3, TRPM8 and TRPC4/C5) are also of significant interest.
This Special Issue will review the preclinical promise and therapeutic value of TRP channel modulators aimed both established and emerging targets, along with the challenges that these compounds may face in clinical practice. Experimental and clinical studies with pain, itch and inflammation will be discussed, along with the emerging roles of TRP gene polymorphism and epigenetic regulation in disease risk and altered sensory perception. Critical review articles of old concepts and new thoughts are also welcome for consideration.
Dr. Arpad Szallasi
Dr. Ari-Pekka Koivisto
Guest Editors
Manuscript Submission Information
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Keywords
- TRP channels
- “thermoTRP” channels
- neuropathic pain
- inflammatory pain
- cancer pain
- pruritic skin iseases
- itch
- neurogenic inflammation
- migraine
