Special Issue "Cancer Pain: From Basic Research to Drug Discovery and Clinical Studies"

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Survivorship and Quality of Life".

Deadline for manuscript submissions: 20 January 2024 | Viewed by 859

Special Issue Editors

Department of Pathology and Experimental Cancer Research, Faculty of Medicine, Semmelweis University, Budapest, Hungary
Interests: the capsaicin (vanilloid) receptor TRPV1; “thermoTRP” expression in cancer; TRP channels as oncotargets; TRP channels as tumor suppressors; sensory nerve-tumor interactions; oncothermia
Special Issues, Collections and Topics in MDPI journals
Department of Physiology and Pharmacology, Health Sciences Center, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil
Interests: pharmacology of pain; analgesics; TRP channels; TRPA1; TRPV1
Special Issues, Collections and Topics in MDPI journals
Dr. Andreea Dumele
E-Mail Website
Guest Editor
National Institute of Oncology, Pain Management Outpatient Clinic, 1122 Budapest, Hungary
Interests: cancer pain management

Special Issue Information

Dear Colleagues,

Cancer pain is one of the worst forms of chronic pain, with opioids being the mainstay of treatment. Unfortunately, most patients quickly develop opioid tolerance, leaving them with few therapeutic alternatives while battling this deadly disease. Thus, there is an urgent need to identify molecular mechanisms driving cancer pain to develop novel analgesic drugs. Most cancer pain occurs when the tumor destroys tissues or presses on nerves. However, cancer cells can also produce substances that make normally innocuous stimuli feel painful. Furthermore, therapeutic interventions can induce pain as an adverse effect, as exemplified by chemotherapy-induced peripheral neuropathy.

With this Special Issue, we aim to explore the current state of the cancer pain field, from basic research through to drug discovery and the development to clinical trials. Original research papers, reviews, clinical studies, and meta-analyses of clinical trials are all welcome to contribute.

Dr. Arpad Szallasi
Prof. Dr. Gabriela Trevisan
Dr. Andreea Dumele
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

10 pages, 1294 KiB  
Article
Methylene Blue for the Treatment of Radiation-Induced Oral Mucositis during Head and Neck Cancer Treatment: An Uncontrolled Cohort
Cancers 2023, 15(15), 3994; https://doi.org/10.3390/cancers15153994 - 07 Aug 2023
Viewed by 626
Abstract
Pain from radiation-therapy-induced oral mucositis during head-neck cancer treatment is aggravated by concurrent chemotherapy and commonly fails traditional treatments. To explore safe and sustainable alternatives, we investigated methylene blue oral rinse to reduce radiation-therapy-related oral mucositis pain. For this, we conducted a retrospective [...] Read more.
Pain from radiation-therapy-induced oral mucositis during head-neck cancer treatment is aggravated by concurrent chemotherapy and commonly fails traditional treatments. To explore safe and sustainable alternatives, we investigated methylene blue oral rinse to reduce radiation-therapy-related oral mucositis pain. For this, we conducted a retrospective observational cohort study in a tertiary-care academic care cancer center including 85 patients with refractory oral mucositis pain during radiation therapy for head-neck cancer. Changes in pain (scale 0–10), oral function burden (scale 0–6) and requirement for percutaneous endoscopic gastrostomy tube placement were measured. Among 58 patients, 60% received radiation therapy alone and 40% received concurrent chemotherapy-radiation therapy. Methylene blue oral rinse (MBOR) significantly decreased oral mucositis pain for at least 6.2 h (median + SD 8 ± 1.68 before vs. 2 ± 2.20 after; p < 0.0001) and oral function burden (3.5 ± 1.33 before vs. 0 ± 0.86 after; p < 0.0001). Eleven patients (19%) had percutaneous endoscopic gastrostomy tubes placed before using methylene blue oral rinse; subsequently, four (36%) resumed oral alimentation after methylene blue oral rinse. Two patients (3%) required percutaneous endoscopic gastrostomy tubes despite methylene blue oral rinse. Minimal adverse events were reported (n = 9, 15%). Our study showed that methylene blue oral rinse was an effective and safe topical treatment for opioid-refractory oral pain from oral mucositis associated with radiation therapy for head-neck cancer. Full article
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