miRNAs in Carcinogenesis of Solid and Hematological Malignancies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 1814
Special Issue Editor
Interests: immunodeficiency; autoimmunity; neuro-endocrino-immunology; pharmacogenomics; soluble molecules; immune-mediated diseases; allergies; vaccines
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The increased incidence of solid and hematological malignancies places heightened emphasis on the genetic and epigenetic factors that play a greater role in the etiopathogenesis of individual malignancies and the intricate relationship between individual risk factors. Several risk factors including obesity, alcohol abuse, viral infections (i.e., papillomavirus, Epstein Barr virus), and the use of steroid hormones (i.e., androgens, estrogens) are now widely known to be related to the occurrence of specific malignancies. Knowledge regarding the role of proteins (i.e., alarmins, cytokines) and ions in carcinogenesis is revealing a fascinating scenario. MicroRNAs (miRNAs) are small, noncoding molecules of approximately twenty two nucleotides with crucial roles in both healthy and pathological cells. Their expression depends not only on genetic factors, but also on epigenetic mechanisms like genomic imprinting and the inactivation of X chromosome in females. miRNAs are related to the development of pathologies, including neoplastic ones. Steroid hormones, catecholamines, and growth factors (i.e., epidermal growth factor, fibroblast growth factor) play a role in carcinogenesis via the regulation of human telomerase reverse transcriptase. There are data in the literature that demonstrate a link between hormones (i.e., estrogens, androgens, catecholamines) and telomerase. Given these premises, this Special Issue aims to associate miRNAs and other risk factors in the carcinogenesis of solid and hematological malignancies.
Dr. Giuseppe Murdaca
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- miRNAs
- hormones
- telomerase
- alarmins
- cytokines
- cancer
- hematological malignancies
