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Special Issue "10th Anniversary of Biomedicines-Immunopathogenesis of Autoimmune Diseases"
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: closed (15 May 2023) | Viewed by 5222
Special Issue Editor
Interests: atherosclerosis; immunodeficiency; autoimmunity; neuro-endocrine-immunology; pharmacogenomics; soluble molecule; immune-mediated diseases; allergies
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Special Issue Information
Autoimmune diseases are multifactorial conditions, in which both genetic and environmental factors play a crucial role. Although they are characterized by different phenotypes, these disorders often share a common and complex environment of cytokines involved in their pathogenesis. Among them, interleukin (IL)-31 and IL-33 have been extensively studied, leading to the most recent theory of an "IL-31 / IL-33 axis" that could be involved in the genesis of autoimmune diseases. In addition to the latter, also other molecules belonging to the class of "alarmins", including defensins (α, β), cathelicidin / LL-37, the high mobility group box-1 (HMGB1) and heat shock proteins (HSP) IL-1α and S100 are involved in the genesis of the pathogenetic mechanisms underlying various autoimmune diseases, as well as in the progression and chemoresistance of some forms of tumors. More recent studies have focused on the role of the gut microbiome in shaping the immune system, contributing to the pathogenesis of many diseases involving the whole organism. Similarly, 1.25 (OH) 2D3 also plays a key role in modulating the immune response, on which it acts through binding to the vitamin D receptor (VDR). In some autoimmune diseases such as systemic sclerosis (SSc) and systemic lupus erythematosus (SLE) the role of the human leukocyte G antigen (HLA-G) has been recognized in the complex immunological pathogenesis of these two autoimmune diseases, where it is expressed in different cell populations such as T lymphocytes, NK cells and APCs. Finally, a growing interest concerns miRNAs, which alterations and polymorphisms have been found to be involved in the pathogenesis of autoimmune diseases, paving the way for the identification of new therapeutic approaches in the future.
Dr. Giuseppe Murdaca
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- IL-31 / IL-33 axis and autoimmune diseases
- alarmins and autoimmune diseases
- microbiome and autoimmune diseases
- vitamin D and autoimmune diseases
- HLA-G and autoimmune diseases
- miRNA and autoimmune diseases
Related Special Issue
- Biomedicines: 10th Anniversary in Biomedicines (31 articles)