ijms-logo

Journal Browser

Journal Browser

Oral Cancer and Disease in Humans and Animals

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 961

Special Issue Editors


E-Mail Website
Guest Editor
1. Department of Veterinary Medicine, University Institute of Health Sciences (IUCS-CESPU), 4585-116 Gandra, Portugal
2. UNIPRO—Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS-CESPU), Gandra, Portugal
3. Pathology Department, INNO Serviços Especializados em Veterinária, Braga, Portugal
Interests: oral cancer; veterinary pathology; comparative pathology; molecular pathology; immunohistochemistry

E-Mail Website
Guest Editor
1. Department of Oral Medicine and Oral Surgery, University Institute of Health Sciences (IUCS-CESPU), 4585-116 Gandra, Portugal
2. UNIPRO—Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS-CESPU), Gandra, Portugal
Interests: oral cancer; oral leukoplakia; prognostic markers; laser; immunohistochemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The increase in the mean life expectancy of humans as well as companion animals probably contributes to a higher incidence of neoplasms, with oncological disease today representing a major cause of death; however, there are important gaps in the knowledge of and subsequent interventions in these neoplasms, including many factors, such as the late diagnosis of neoplastic lesions and a lack of treatment options, that contribute to the poor survival of these patients. From this point of view, the molecular study of tumors and the search for molecules with prognostic value (cancer biomarkers, molecular diagnostics, immunotherapy, etc.) can open doors for a specialized characterization of tumors of each human or companion animal patient and better prognoses. This Special Issue is interested in the molecular pathology of oral carcinogenesis (including head and neck neoplasms) in human and veterinary patients that might contribute to an increase in the knowledge on oral oncology.

Dr. Maria Leonor Delgado
Dr. Luís Monteiro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer biomarkers
  • mitosis
  • cell cycle
  • animal models
  • comparative pathology
  • cancer stem cell
  • cancer epidemiology
  • cancer risk factors
  • cancer biomarker
  • tissue microarray
  • immunohistochemistry
  • microarray
  • microRNA
  • molecular diagnostics
  • proteomics
  • tumor microenvironment
  • treatment response
  • targeted therapy
  • immunotherapy
  • translation cancer research
  • zoonosis
  • gross pathology

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

21 pages, 1574 KiB  
Review
A Review of the Repair of DNA Double Strand Breaks in the Development of Oral Cancer
by Stephen S. Prime, Piotr Darski, Keith D. Hunter, Nicola Cirillo and E. Kenneth Parkinson
Int. J. Mol. Sci. 2024, 25(7), 4092; https://doi.org/10.3390/ijms25074092 - 07 Apr 2024
Viewed by 681
Abstract
We explore the possibility that defects in genes associated with the response and repair of DNA double strand breaks predispose oral potentially malignant disorders (OPMD) to undergo malignant transformation to oral squamous cell carcinoma (OSCC). Defects in the homologous recombination/Fanconi anemia (HR/FA), but [...] Read more.
We explore the possibility that defects in genes associated with the response and repair of DNA double strand breaks predispose oral potentially malignant disorders (OPMD) to undergo malignant transformation to oral squamous cell carcinoma (OSCC). Defects in the homologous recombination/Fanconi anemia (HR/FA), but not in the non-homologous end joining, causes the DNA repair pathway to appear to be consistent with features of familial conditions that are predisposed to OSCC (FA, Bloom’s syndrome, Ataxia Telangiectasia); this is true for OSCC that occurs in young patients, sometimes with little/no exposure to classical risk factors. Even in Dyskeratosis Congenita, a disorder of the telomerase complex that is also predisposed to OSCC, attempts at maintaining telomere length involve a pathway with shared HR genes. Defects in the HR/FA pathway therefore appear to be pivotal in conditions that are predisposed to OSCC. There is also some evidence that abnormalities in the HR/FA pathway are associated with malignant transformation of sporadic cases OPMD and OSCC. We provide data showing overexpression of HR/FA genes in a cell-cycle-dependent manner in a series of OPMD-derived immortal keratinocyte cell lines compared to their mortal counterparts. The observations in this study argue strongly for an important role of the HA/FA DNA repair pathway in the development of OSCC. Full article
(This article belongs to the Special Issue Oral Cancer and Disease in Humans and Animals)
Show Figures

Figure 1

Back to TopTop