Tumor Microenvironment: Molecular Mechanism and Signaling Pathway Involved in Cancer Metastasis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 2284
Special Issue Editors
Interests: gynecological oncology; endometrial cancer; metastasis; translational research; biomarkers.
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Tumors are highly complex entities composed of a plethora of cell types, which altogether comprise what we call the “tumor microenvironment” (TME). Such an ecosystem contains immune, endothelial or nerve cells, as well as fibroblasts, which dynamically interact with cancer cells both at the physical and biochemical levels. Such interactions lead to acute and chronic alterations in the phenotypic characteristics of cancer and non-cancer cells, ultimately affecting tumor progression. Of particular relevance is the effect that the TME exerts over the migratory and invasive capacities of cancer cells, regulating regional and distant tumor dissemination through metastasis formation, a key feature that determines the survival of cancer patients. Understanding the TME-related mechanisms and signaling pathways related to tumor invasion and metastatic dissemination, as well as immunosuppression and therapy resistance, will provide a more detailed view of the biology of tumor progression and an opportunity to design new therapeutic approaches, specifically tackling metastasis formation.
For this Special Issue of the International Journal of Molecular Sciences, we invite authors to submit original and review articles that provide new insights on how the TME influences tumor dissemination and metastasis. Articles covering new findings on TME-related mechanisms altering cancer motility, invasion, angiogenesis, hematogenous, or lymphatic dissemination, as well as immune evasion or therapy resistance, are welcomed.
Dr. Miguel Abal
Dr. Jorge Barbazán
Guest Editors
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