Sepsis: Molecular Research
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 3123
Interests: short stay unit; infection, sepsis; trauma; syncope; pulmonary embolism; inflammatory bowel disease; gastroenteritis; gastrointestinal bleeding; diverticulitis
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Sepsis has always been a major challenge for emergency physicians and intensivists. Over the years, the definition of sepsis has evolved from a simple description of the main symptoms due to infection to the presence of damage to an organ distant from the site of infection due to an inappropriate response. The understanding of the basic mechanisms has also progressively evolved. Starting from the search for factors related to the causative microorganism and host, it has been recognized that the components related to sepsis include the pathogen, the immune system, the endothelia and microcirculation, blood coagulation, and the nervous system with microglia and neurons. However, knowledge of physiopathologic mechanisms has evolved without finding new therapies. Sepsis is still treated with fluids, antibiotics, vasopressors, and, when possible, surgical removal of the focus of infection. For this reason, the search for physiopathologic molecular mechanisms that may lead to early diagnosis or more effective treatment must continue. Therefore, I invite all investigators working on sepsis to contribute with original papers or a literature review on all molecular mechanisms related to this topic, from those related to the responsible pathogens to those related to the host.
Dr. Marcello Candelli
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- septic shock
- organ disfunction