Advances in Functional Gel (2nd Edition)

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Chemistry and Physics".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 1077

Special Issue Editors


E-Mail Website
Guest Editor
Institute for the Study of Nanostructured Materials, ISMN–CNR, Palermo, c/o Department ChiBioFarAm, University of Messina, 98166 Messina, Italy
Interests: materials chemistry; green chemistry; nanotechnology; environmental remediation; advanced materials; functional coating; colloidal nanoparticles; smart and hi-tech textiles; (waste)water treatment; multifunctional hybrid materials and nanocomposites; sensing technologies; bio-based blended polymers; circular economy
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Institute for the Study of Nanostructured Materials, ISMN—CNR, Palermo, c/o Department of ChiBioFarAm, University of Messina, 98166 Messina, Italy
Interests: material chemistry; nanotechnology; sol–gel chemistry; polymer science; Hi-tech textiles; functional coatings; sustainability; stimuli-responsive polymers
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Institute for the Study of Nanostructured Materials, ISMN—CNR, Palermo, c/o Department of ChiBioFarAm, University of Messina, 98166 Messina, Italy
Interests: materials chemistry; green chemistry; nanotechnology; environmental remediation; advanced materials; filtration membranes; stimuli-responsive polymers; functional systems

Special Issue Information

Dear Colleagues,

In recent years, due to the increasing demands of modern society for sustainability, environmental protection and pollution prevention, there has been a growing global need for more efficient, eco-friendly and long-life materials.

In this framework, it appears to be quite necessary to encompass a range of strategies that can help in the transition towards a circular economy, by supporting the following:

  • A reduction in primary raw material consumption, fossil-based reagents and waste production;
  • The development of multifunctional products that can help in saving money and reducing pollution, by decreasing the number of products in our everyday life;
  • The maintenance of the final product performances over time, by improving their resistance to external agents and to consumption by end users, thus extending the product life cycle.

Using this reasoning, recent research studies in materials chemistry are moving towards the development of innovative and smart (multi)functional gel-based materials, featuring a wide range of interesting properties for applications in biomedical, sensing, textiles, catalysis, building, cultural heritage, blue-growth, automotive and environmental industrial sectors.

Additionally, nanotechnology has been shown to be a determinant in the rational design of these novel functional nanostructured gel formulations, leading to advanced nano-hybrid or nanocomposite gels, also useful as coatings for surface properties’ implementation, such as anti-vegetative or antibacterial, hydrophobic, anti-stain, fire-retardant, controlled drug release, molecule detection, protection and mechanical resistance.

In this regard, gel technologies are receiving considerable attention for the design and development of functional hybrid organic and inorganic systems, based on hosting (blended) polymeric matrices and opportune functional nanofillers, thanks to the advantages, such as low process temperature, no cytotoxicity, high final product homogeneity, hazardous solvent’s absence, high versatility and stable binding to functional molecules or surfaces.

Furthermore, green and eco-friendly gel-based synthetic protocols can be established in combination with naturally derived polymers and bio-based or secondary raw materials, thus resulting in new eco-friendly products, which can be recycled and re-used.

Dr. Maria Rosaria Plutino
Dr. Silvia Sfameni
Dr. Giulia Rando
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • smart gel systems
  • nanohybrid gels
  • nanocomposite gels
  • innovative advanced gels
  • bio-based gel materials
  • sol–gel technique
  • functional gel coatings

Related Special Issue

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

18 pages, 22447 KiB  
Article
Rheological and Injectability Evaluation of Sterilized Poloxamer-407-Based Hydrogels Containing Docetaxel-Loaded Lipid Nanoparticles
by Ana Camila Marques, Paulo C. Costa, Sérgia Velho and Maria Helena Amaral
Gels 2024, 10(5), 307; https://doi.org/10.3390/gels10050307 - 1 May 2024
Viewed by 789
Abstract
Nanostructured lipid carriers (NLCs) have the potential to increase the bioavailability and reduce the side effects of docetaxel (DTX). However, only a small fraction of nanoparticles given intravenously can reach a solid tumor. In situ-forming gels combined with nanoparticles facilitate local administration and [...] Read more.
Nanostructured lipid carriers (NLCs) have the potential to increase the bioavailability and reduce the side effects of docetaxel (DTX). However, only a small fraction of nanoparticles given intravenously can reach a solid tumor. In situ-forming gels combined with nanoparticles facilitate local administration and promote drug retention at the tumor site. Injectable hydrogels based on poloxamer 407 are excellent candidates for this hybrid nanoparticle–hydrogel system because of their thermoresponsive behavior and biocompatibility. Therefore, this work aimed to develop injectable poloxamer hydrogels containing NLCs for intratumoral delivery of DTX. To ensure sterility, the obtained hydrogels were autoclaved (121 °C for 15 min) after preparation. Then, the incorporation of NLCs into the poloxamer hydrogels and the impact of steam sterilization on the nanocomposite hydrogels were evaluated concerning sol–gel transition, injectability, and physicochemical stability. All formulations were extruded through the tested syringe–needle systems with acceptable force (2.2–13.4 N) and work (49.5–317.7 N·mm) of injection. Following steam sterilization, injection became easier in most cases, and the physicochemical properties of all hydrogels remained practically unchanged according to the spectroscopical and thermal analysis. The rheological evaluation revealed that the nanocomposite hydrogels were liquid at 25 °C and underwent rapid gelation at 37 °C. However, their sterilized counterparts gelled at 1–2 °C above body temperature, suggesting that the autoclaving conditions employed had rendered these nanocomposite hydrogels unsuitable for local drug delivery. Full article
(This article belongs to the Special Issue Advances in Functional Gel (2nd Edition))
Show Figures

Figure 1

Back to TopTop