Glycative Stress and Anti-glycative Mechanisms in Aging and Age-Related Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".
Deadline for manuscript submissions: closed (20 December 2023) | Viewed by 7414
Special Issue Editors
Interests: proteostasis; aging; nutrition; autophagy; glycation
Special Issue Information
Dear Colleagues,
Glycation is a non-enzymatic process by which sugars or sugar metabolites are covalently bound to proteins, lipids, and DNA. Glycated biomolecules are generated in hyperglycemic states, which occur in diabetes mellitus and upon the consumption of high-sugar diets in non-diabetics, particularly in older individuals. In order to combat glycative stress, there are different defense mechanisms against the accumulation of advanced glycation end products (AGEs). However, the age-related decline in the function of these activities results in glycative modification and damage upon aging and age-related diseases. Such damage may be etiologic for aging and age-related diseases. Exploring the role of anti-AGEs mechanisms in different tissues/organs in the context of aging will help to elucidate the cellular basis of glycative stress in age-related diseases and inform the development of future therapeutic tools.
This Special Issue will highlight glycation-related topics, including:
- Pathological impact of glycative stress in human diseases and diabetes complications
- In vivo and in vitro models for studying the pathological impact of glycative stress.
- Enzymatic systems limiting the glycation process (glyoxalase system, Park7/DJ-1, etc.) and the proteolytic pathways involved in AGE clearance (autophagy, UPS).
- The health benefits of the use of nutrition, phytocompounds, and pharmacological drugs to combat glycative stress.
- Novel analytical methods for evaluating glycative stress.
- Epidemiological studies providing information about glycation-related complications.
Dr. Eloy Bejarano
Prof. Dr. Allen Taylor
Guest Editors
Manuscript Submission Information
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Keywords
- diabetes
- aging
- nutrition
- diet
- advanced glycation end products
- glyoxalase system
- anti-glycating agents