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Cells
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Latest Research on Epithelial-Mesenchymal Transition (EMT)
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Latest Research on Epithelial-Mesenchymal Transition (EMT)

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".

Deadline for manuscript submissions: closed (15 October 2021) | Viewed by 19291

Special Issue Editors

Prof. Dr. Oriana Trubiani

E-Mail Website
Guest Editor
Department of Innovative Technologies in Medicine & Dentistry, University “G. d’Annunzio”, Chieti-Pescara, via dei Vestini, 31, 66100 Chieti, Italy
Interests: stem cells; biomaterials; regenerative medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Francesca Diomede

E-Mail Website
Guest Editor
Department of Innovative Technologies in Clinical Medicine & Dentistry, University “G. d’Annunzio” Chieti-Pescara, 66100 Chieti, Italy
Interests: regenerative medicine; stem cells; microfluidics; oral stem cells; restorative dentistry; osteoregeneration; biomaterials; extracellular vesicles; exosomes; liposomes
Special Issues, Collections and Topics in MDPI journals
Dr. Jacopo Pizzicanella

E-Mail Website
Guest Editor
Department of Engeneering and Geology, University “G. d’Annunzio” Chieti-Pescara, 66100 Chieti, Italy
Interests: regenerative medicine; stem cells; oral stem cells; restorative dentistry; osteoregeneration; biomaterials; epithelial–mesenchymal transition; extracellular vesicles; exosomes; liposomes
Special Issues, Collections and Topics in MDPI journals
Dr. Guya Marconi

E-Mail Website
Guest Editor
Department of Innovative Technologies in Clinical Medicine & Dentistry, University “G. d’Annunzio” Chieti-Pescara, 66100 Chieti, Italy
Interests: regenerative medicine; stem cells; microfluidics; oral stem cells; restorative dentistry; osteoregeneration; biomaterials; epithelial–mesenchymal transition; extracellular vesicles; exosomes; liposomes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The epithelial–mesenchymal transition (EMT) is a process that leads to the transdifferentiation of epithelial cells into motile mesenchymal cells. This is an essential event in development, wound healing, and stem cell behaviour, and contributes pathologically to fibrosis and cancer progression.

The cell differentiation is regulated by several transcription factors and molecular mechanisms that still remain unknown. During EMT, cell–cell and cell–extracellular matrix interactions are remodelled, and a new transcriptional programme is activated to promote the modifications in cellular morphology and functions. We invite colleagues to contribute editorials, original research articles, or review papers with recent findings on the mechanisms and roles of EMT in normal and neoplastic tissues, during physiological and pathological processes.

Prof. Oriana Trubiani
Dr. Francesca Diomede
Dr. Jacopo Pizzicanella
Dr. Guya Diletta Marconi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epithelial–mesenchymal transition
  • fibrosis
  • wound healing
  • cancer
  • development
  • stem cell behaviour
  • transcriptional factor
  • cell differentiation

Published Papers (3 papers)

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Research

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21 pages, 3287 KiB  
Article
Snail Upregulates Transcription of FN, LEF, COX2, and COL1A1 in Hepatocellular Carcinoma: A General Model Established for Snail to Transactivate Mesenchymal Genes
by Tam Minh Ly, Yen-Cheng Chen, Ming-Che Lee, Chi-Tan Hu, Chuan-Chu Cheng, Hsin-Hou Chang, Ren-In You and Wen-Sheng Wu
Cells 2021, 10(9), 2202; https://doi.org/10.3390/cells10092202 - 26 Aug 2021
Cited by 5 | Viewed by 2636
Abstract
SNA is one of the essential EMT transcriptional factors capable of suppressing epithelial maker while upregulating mesenchymal markers. However, the mechanisms for SNA to transactivate mesenchymal markers was not well elucidated. Recently, we demonstrated that SNA collaborates with EGR1 and SP1 to directly [...] Read more.
SNA is one of the essential EMT transcriptional factors capable of suppressing epithelial maker while upregulating mesenchymal markers. However, the mechanisms for SNA to transactivate mesenchymal markers was not well elucidated. Recently, we demonstrated that SNA collaborates with EGR1 and SP1 to directly upregulate MMP9 and ZEB1. Remarkably, a SNA-binding motif (TCACA) upstream of EGR/SP1 overlapping region on promoters was identified. Herein, we examined whether four other mesenchymal markers, lymphoid enhancer-binding factor (LEF), fibronectin (FN), cyclooxygenase 2 (COX2), and collagen type alpha I (COL1A1) are upregulated by SNA in a similar fashion. Expectedly, SNA is essential for expression of these mesenchymal genes. By deletion mapping and site directed mutagenesis coupled with dual luciferase promoter assay, SNA-binding motif and EGR1/SP1 overlapping region are required for TPA-induced transcription of LEF, FN, COX2 and COL1A1. Consistently, TPA induced binding of SNA and EGR1/SP1 on relevant promoter regions of these mesenchymal genes using ChIP and EMSA. Thus far, we found six of the mesenchymal genes are transcriptionally upregulated by SNA in the same fashion. Moreover, comprehensive screening revealed similar sequence architectures on promoter regions of other SNA-upregulated mesenchymal markers, suggesting that a general model for SNA-upregulated mesenchymal genes can be established. Full article
(This article belongs to the Special Issue Latest Research on Epithelial-Mesenchymal Transition (EMT))
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Review

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14 pages, 319 KiB  
Review
Aspects of the Epigenetic Regulation of EMT Related to Cancer Metastasis
by Ewa Nowak and Ilona Bednarek
Cells 2021, 10(12), 3435; https://doi.org/10.3390/cells10123435 - 06 Dec 2021
Cited by 40 | Viewed by 3979
Abstract
Epithelial to mesenchymal transition (EMT) occurs during the pathological process associated with tumor progression and is considered to influence and promote the metastatic cascade. Characterized by loss of cell adhesion and apex base polarity, EMT enhances cell motility and metastasis. The key markers [...] Read more.
Epithelial to mesenchymal transition (EMT) occurs during the pathological process associated with tumor progression and is considered to influence and promote the metastatic cascade. Characterized by loss of cell adhesion and apex base polarity, EMT enhances cell motility and metastasis. The key markers of the epithelial to mesenchymal transition are proteins characteristic of the epithelial phenotype, e.g., E-cadherin, cytokeratins, occludin, or desmoplakin, the concentration and activity of which are reduced during this process. On the other hand, as a result of acquiring the characteristics of mesenchymal cells, an increased amount of N-cadherin, vimentin, fibronectin, or vitronectin is observed. Importantly, epithelial cells undergo partial EMT where some of the cells show both epithelial and mesenchymal characteristics. The significant influence of epigenetic regulatory mechanisms is observed in the gene expression involved in EMT. Among the epigenetic modifications accompanying incorrect genetic reprogramming in cancer are changes in the level of DNA methylation within the CpG islands and posttranslational covalent changes of histone proteins. All observed modifications, which are stable but reversible changes, affect the level of gene expression leading to the development and progression of the disease, and consequently affect the uncontrolled growth of the population of cancer cells. Full article
(This article belongs to the Special Issue Latest Research on Epithelial-Mesenchymal Transition (EMT))
14 pages, 2063 KiB  
Review
Epithelial-Mesenchymal Transition (EMT): The Type-2 EMT in Wound Healing, Tissue Regeneration and Organ Fibrosis
by Guya D. Marconi, Luigia Fonticoli, Thangavelu Soundara Rajan, Sante D. Pierdomenico, Oriana Trubiani, Jacopo Pizzicannella and Francesca Diomede
Cells 2021, 10(7), 1587; https://doi.org/10.3390/cells10071587 - 23 Jun 2021
Cited by 152 | Viewed by 11656
Abstract
The epithelial–mesenchymal transition (EMT) is an essential event during cell development, in which epithelial cells acquire mesenchymal fibroblast-like features including reduced intercellular adhesion and increased motility. EMT also plays a key role in wound healing processes, which are mediated by inflammatory cells and [...] Read more.
The epithelial–mesenchymal transition (EMT) is an essential event during cell development, in which epithelial cells acquire mesenchymal fibroblast-like features including reduced intercellular adhesion and increased motility. EMT also plays a key role in wound healing processes, which are mediated by inflammatory cells and fibroblasts. These cells secrete specific factors that interact with molecules of the extracellular matrix (ECM) such as collagens, laminins, elastin and tenascins. Wound healing follows four distinct and successive phases characterized by haemostasis, inflammation, cell proliferation and finally tissue remodeling. EMT is classified into three diverse subtypes: type-1 EMT, type-2 EMT and type-3 EMT. Type-1 EMT is involved in embryogenesis and organ development. Type-2 EMT is associated with wound healing, tissue regeneration and organ fibrosis. During organ fibrosis, type-2 EMT occurs as a reparative-associated process in response to ongoing inflammation and eventually leads to organ destruction. Type-3 EMT is implicated in cancer progression, which is linked to the occurrence of genetic and epigenetic alterations, in detail the ones promoting clonal outgrowth and the formation of localized tumors. The current review aimed at exploring the role of EMT process with particular focus on type-2 EMT in wound healing, fibrosis and tissue regeneration, as well as some recent progresses in the EMT and tissue regeneration field, including the modulation of EMT by biomaterials. Full article
(This article belongs to the Special Issue Latest Research on Epithelial-Mesenchymal Transition (EMT))
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