Cellular and Molecular Basis of Wound Healing II

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: 1 July 2024 | Viewed by 4019

Special Issue Editors


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Guest Editor
Dipartimento di Scienze e Innovazione Tecnologica (DiSIT), University of Piemonte Orientale "Amedeo Avogadro", Viale Teresa Michel 11, 15121 Alessandria, Italy
Interests: honey; natural products; propolis; confocal microscopy; cell signaling; aquaporins; wound repair; tissue regeneration
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Special Issue Information

Dear Colleagues,

The success of the first edition of this Special Issue encouraged us to launch a second edition.

Wound healing is a common biological process across all multicellular organisms, which is critical for survival as it restores tissue integrity.

Wound healing encompasses the spatial and temporal participation of several cells and tissue processes, orchestrating cellular responses supporting inflammation, matrix remodeling, proliferation, and angiogenesis.

Recent developments in wound repair and regeneration mechanisms, as well as innovative methodologies aiming to heal chronic/acute wounds and reduce scar formation, make this the appropriate time for a Special Issue that highlights the cellular and molecular events involved in wound-healing mechanisms.

This Special Issue presents cutting-edge research in the fields of experimental cellular and molecular biology (in vitro and in vivo studies) of tissue regeneration and wound healing, as well as mechanisms underpinning wound healing failure.

Studies carried out on wound models reconsidering the roles of growth factors, cytokines, and stem cells will also be considered.

Dr. Simona Martinotti
Dr. Elia Ranzato
Guest Editors

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Keywords

  • scratch wound assay
  • Ca2+ signaling
  • burns and wound healing
  • keratinocytes biology
  • matrix remodelling
  • inflammation and wound healing
  • gene therapy in wound healing
  • wound management
  • wound healing
  • tissue regeneration
  • cell and molecular biology
  • wounds
  • difficult-to-heal wounds
  • chronic/acute wounds

Published Papers (3 papers)

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Research

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18 pages, 3256 KiB  
Article
Increased Levels of BAMBI Inhibit Canonical TGF-β Signaling in Chronic Wound Tissues
by Sabrina Ehnert, Helen Rinderknecht, Chao Liu, Melanie Voss, Franziska M. Konrad, Wiebke Eisler, Dorothea Alexander, Kristian-Christos Ngamsri, Tina Histing, Mika F. Rollmann and Andreas K. Nussler
Cells 2023, 12(16), 2095; https://doi.org/10.3390/cells12162095 - 18 Aug 2023
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Abstract
Chronic wounds affect more than 2% of the population worldwide, with a significant burden on affected individuals, healthcare systems, and societies. A key regulator of the entire wound healing cascade is transforming growth factor beta (TGF-β), which regulates not only inflammation and extracellular [...] Read more.
Chronic wounds affect more than 2% of the population worldwide, with a significant burden on affected individuals, healthcare systems, and societies. A key regulator of the entire wound healing cascade is transforming growth factor beta (TGF-β), which regulates not only inflammation and extracellular matrix formation but also revascularization. This present work aimed at characterizing wound tissues obtained from acute and chronic wounds regarding angiogenesis, inflammation, as well as ECM formation and degradation, to identify common disturbances in the healing process. Serum and wound tissues from 38 patients (N = 20 acute and N = 18 chronic wounds) were analyzed. The patients’ sera suggested a shift from VEGF/VEGFR to ANGPT/TIE2 signaling in the chronic wounds. However, this shift was not confirmed in the wound tissues. Instead, the chronic wound tissues showed increased levels of MMP9, a known activator of TGF-β. However, regulation of TGF-β target genes, such as CTGF, COL1A1, or IL-6, was absent in the chronic wounds. In wound tissues, all three TGF-β isoforms were expressed with increased levels of TGF-β1 and TGF-β3 and a reporter assay confirmed that the expressed TGF-β was activated. However, Western blots and immunostaining showed decreased canonical TGF-β signaling in the respective chronic wound tissues, suggesting the presence of a TGF-β inhibitor. As a potential regulatory mechanism, the TGF-β proteome profiler array suggested elevated levels of the TGF-β pseudo-receptor BAMBI. Also, tissue expression of BAMBI was significantly increased not only in chronic wounds (10.6-fold) but also in acute wounds that had become chronic (9.5-fold). In summary, our data indicate a possible regulatory role of BAMBI in the development of chronic wounds. The available few in vivo studies support our findings by postulating a therapeutic potential of BAMBI for controlling scar formation. Full article
(This article belongs to the Special Issue Cellular and Molecular Basis of Wound Healing II)
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Review

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13 pages, 901 KiB  
Review
Role of the Skin Immune System in Wound Healing
by Angela Cioce, Andrea Cavani, Caterina Cattani and Fernanda Scopelliti
Cells 2024, 13(7), 624; https://doi.org/10.3390/cells13070624 - 4 Apr 2024
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Abstract
Wound healing is a dynamic and complex process, characterized by the coordinated activities of multiple cell types, each with distinct roles in the stages of hemostasis, inflammation, proliferation, and remodeling. The cells of the immune system not only act as sentinels to monitor [...] Read more.
Wound healing is a dynamic and complex process, characterized by the coordinated activities of multiple cell types, each with distinct roles in the stages of hemostasis, inflammation, proliferation, and remodeling. The cells of the immune system not only act as sentinels to monitor the skin and promote homeostasis, but they also play an important role in the process of skin wound repair. Skin-resident and recruited immune cells release cytokines and growth factors that promote the amplification of the inflammatory process. They also work with non-immune cells to remove invading pathogens and debris, as well as guide the regeneration of damaged host tissues. Dysregulation of the immune system at any stage of the process may lead to a prolongation of the inflammatory phase and the development of a pathological condition, such as a chronic wound. The present review aims to summarize the roles of different immune cells, with special emphasis on the different stages of the wound healing process. Full article
(This article belongs to the Special Issue Cellular and Molecular Basis of Wound Healing II)
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13 pages, 3334 KiB  
Review
Wound Repair and Ca2+ Signalling Interplay: The Role of Ca2+ Channels in Skin
by Gregorio Bonsignore, Simona Martinotti and Elia Ranzato
Cells 2024, 13(6), 491; https://doi.org/10.3390/cells13060491 - 11 Mar 2024
Viewed by 895
Abstract
The process of wound healing is intricate and tightly controlled, involving a number of different cellular and molecular processes. Numerous cellular functions, especially those related to wound healing, depend critically on calcium ions (Ca2+). Ca2+ channels are proteins involved in [...] Read more.
The process of wound healing is intricate and tightly controlled, involving a number of different cellular and molecular processes. Numerous cellular functions, especially those related to wound healing, depend critically on calcium ions (Ca2+). Ca2+ channels are proteins involved in signal transduction and communication inside cells that allow calcium ions to pass through cell membranes. Key Ca2+ channel types involved in wound repair are described in this review. Full article
(This article belongs to the Special Issue Cellular and Molecular Basis of Wound Healing II)
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