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Novel Natural Compound for Wound and Tissue Repair and Regeneration 3.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1251

Special Issue Editors


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Guest Editor

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous successful Special Issue “Novel Natural Compound for Wound and Tissue Repair and Regeneration”.

Wound healing is of great importance for skin medicine, with particular interest focused on natural compounds.

Numerous studies have recognized the potential use of natural products as wound-healing agents in terms of their antibacterial, antioxidant, immunomodulatory, and pro-collagen synthesis properties.

The therapeutic virtues of natural compounds have been rediscovered by the medical profession and are gaining acceptance with regard to treating wounds, ulcers, and other surface infections.

Despite the extensive literature available on the clinical uses of natural compounds, the subjacent mechanisms remain largely unknown. With the growing interest in the utilization of natural products and the belief that they are safer than standard therapies, it is crucial that we enhance our knowledge of their efficacy and side effects.

Thus, original articles and reviews that investigate the positive effects of natural compounds on wound healing and the cellular and molecular mechanisms that are involved will be suitable for this Special Issue.

Dr. Elia Ranzato
Dr. Simona Martinotti
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wound repair
  • tissue regeneration
  • natural compounds
  • phytochemicals
  • molecular mechanisms

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Published Papers (2 papers)

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Research

14 pages, 1977 KiB  
Article
Hyaluronic Acid/Ellagic Acid as Materials for Potential Medical Application
by Beata Kaczmarek-Szczepańska, Konrad Kleszczyński, Lidia Zasada, Dorota Chmielniak, Mara Barbara Hollerung, Katarzyna Dembińska, Krystyna Pałubicka, Kerstin Steinbrink, Maria Swiontek Brzezinska and Sylwia Grabska-Zielińska
Int. J. Mol. Sci. 2024, 25(11), 5891; https://doi.org/10.3390/ijms25115891 - 28 May 2024
Viewed by 389
Abstract
The aim of this work was to develop and characterize a thin films composed of hyaluronic acid/ellagic acid for potential medical application. Its principal novelty, distinct from the prior literature in terms of hyaluronic acid films supplemented with phenolic acids, resides in the [...] Read more.
The aim of this work was to develop and characterize a thin films composed of hyaluronic acid/ellagic acid for potential medical application. Its principal novelty, distinct from the prior literature in terms of hyaluronic acid films supplemented with phenolic acids, resides in the predominant incorporation of ellagic acid—a distinguished compound—as the primary constituent of the films. Herein, ellagic acid was dissolved in two different solvents, i.e., acetic acid (AcOH) or sodium hydroxide (NaOH), and the surface properties of the resultant films were assessed using atomic force microscopy and contact angle measurements. Additionally, various physicochemical parameters were evaluated including moisture content, antioxidant activity, and release of ellagic acid in phosphate buffered saline. Furthermore, the evaluation of films’ biocompatibility was conducted using human epidermal keratinocytes, dermal fibroblasts, and human amelanotic melanoma cells (A375 and G361), and the antimicrobial activity was elucidated accordingly against Staphylococcus aureus ATCC 6538 and Pseudomonas aeruginosa ATCC 15442. Our results showed that the films exhibited prominent antibacterial properties particularly against Staphylococcus aureus, with the 80HA/20EA/AcOH film indicating the strong biocidal activity against this strain leading to a significant reduction in viable cells. Comparatively, the 50HA/50EA/AcOH film also displayed biocidal activity against Staphylococcus aureus. This experimental approach could be a promising technique for future applications in regenerative dermatology or novel strategies in terms of bioengineering. Full article
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15 pages, 13912 KiB  
Article
Gelatin Enhances the Wet Mechanical Properties of Poly(D,L-Lactic Acid) Membranes
by Deuk Yong Lee
Int. J. Mol. Sci. 2024, 25(9), 5022; https://doi.org/10.3390/ijms25095022 - 4 May 2024
Viewed by 527
Abstract
Biodegradable (BP) poly(D,L-lactic acid) (PDLLA) membranes are widely used in tissue engineering. Here, we investigate the effects of varying concentrations of PDLLA/gelatin membranes electrospun in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP; C3H2F6O) solvent on their mechanical and physical properties as well [...] Read more.
Biodegradable (BP) poly(D,L-lactic acid) (PDLLA) membranes are widely used in tissue engineering. Here, we investigate the effects of varying concentrations of PDLLA/gelatin membranes electrospun in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP; C3H2F6O) solvent on their mechanical and physical properties as well as their biocompatibility. Regardless of the environmental conditions, increasing the gelatin content resulted in elevated stress and reduced strain at membrane failure. There was a remarkable difference in strain-to-failure between dry and wet PDLLA/gelatin membranes, with wet strains consistently higher than those of the dry membranes because of the hydrophilic nature of gelatin. A similar wet strain (εw = 2.7–3.0) was observed in PDLLA/gelatin membranes with a gelatin content between 10 and 40%. Both dry and wet stresses increased with increasing gelatin content. The dry stress on PDLLA/gelatin membranes (σd = 6.7–9.7 MPa) consistently exceeded the wet stress (σw = 4.5–8.6 MPa). The water uptake capacity (WUC) improved, increasing from 57% to 624% with the addition of 40% gelatin to PDLLA. PDLLA/gelatin hybrid membranes containing 10 to 20 wt% gelatin exhibited favorable wet mechanical properties (σw = 5.4–6.3 MPa; εw = 2.9–3.0); WUC (337–571%), degradability (11.4–20.2%), and excellent biocompatibility. Full article
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