Special Issue "Modeling Developmental Dynamics and Disorders in Zebrafish"
Deadline for manuscript submissions: 29 February 2024 | Viewed by 12108
Interests: zebrafish; heart disease; mitochondrial disease; endocrine disease; melanoma; neural development; pancreatic development and cancer
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Special Issue in Cells: Model Systems and Candidate Genes for Inherited Cardiomyopathies
The Special Issue on “Modeling Developmental Dynamics and Disorders in Zebrafish” welcomes both reviews and original articles focusing on the application of the zebrafish (Danio rerio) organism to answer relevant biological questions on animal development and body functions under physiological or pathological conditions.
The Special Issue is inspired by the growing affirmation of the zebrafish vertebrate model in the field of Developmental Biology and Biomedical Sciences. The discovery of new processes of cell communication, differentiation, and organogenesis is inseparable from the progressive elucidation of the mechanisms underlying several human pathologies of still unknown etiology.
In this perspective, the zebrafish represents an ideal model for the in vivo study of both physiological and pathological processes given its transparency, high manipulability, affordability, and availability of a range of genetic tools, including mutant and transgenic lines, biosensors, and platforms for large-scale drug screening and proof-of-principle testing of innovative therapies.
Dr. Natascia Tiso
Prof. Dr. Francesco Argenton
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Diving Deep: Zebrafish Model in Motor Neuron Degeneration Research
Authors: Vranda Garg; Bart R.H. Geurten
Affiliation: Georg-August-University Göttingen, Department of Cellular Neurobiology, Julia-Lermontowa-Weg 3 37077 Göttingen, Germany; University of Otago, Department of Zoology, 340 Great King Street, 9016 Dunedin, New Zealand
Abstract: In the ever-evolving landscape of biomedical science, the pursuit of effective treatments for motor neuron disorders like amyotrophic lateral sclerosis (ALS), hereditary spastic paraplegia (HSP), spinal muscular atrophy (SMA) is a key priority. A crucial aspect of this endeavour is the development of robust animal models, and the zebrafish stands out as a prime candidate. This model offers significant research potential with its embryonic transparency, rapid life cycle, and notable genetic and neuroanatomical similarities with humans. Despite the difference in locomotion - zebrafish undulate while humans use limbs, the zebrafish presents relevant phenotypic parallels to human motor control disorders, providing valuable insights into neurodegenerative diseases. This review delves into how the zebrafish, through its inherent traits, offers significant insights into the complex behavioural and cellular phenotypes associated with these disorders. Furthermore, we examine recent advancements in high-throughput drug screening using the zebrafish model, a promising avenue for identifying therapeutically potent compounds.