Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.0
6.0
Journals
Cells
Special Issues
Therapeutic Potentials of Adipose-Derived Stem Cells
share announcement

Therapeutic Potentials of Adipose-Derived Stem Cells

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Tissues and Organs".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1790

Special Issue Editor

Prof. Dr. Lukas Prantl

E-Mail Website
Guest Editor
Prof. Dr. med. Lukas Prantl, MD, PhD, MHBA, University Center of Plastic, Aesthetic, Hand and Reconstructive Surgery, University of Regensburg, Applied Stem Cell Research Center, Regensburg, Germany
Interests: tissue engineering; stem cells; adipose stem cells, tissue perfusion; organ and tissue regeneration; organ and tissue transplantation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Stem cells, particularly those derived from adipose tissue, hold great potential for tissue regeneration. Numerous in vitro and in vivo studies in animals confirm this. The various mechanisms of action of adipose stem cells, including cell differentiation, the secretion of numerous cytokines, immunokines, and exosomes, have been described. However, their translation into clinical applications is still in its early stages. Therefore, this Special Issue aims to focus on bridging the gap between fundamental research and clinical applications. The fields of application are diverse, ranging from skin rejuvenation and breast volume augmentation to reconstructive and regenerative applications in arthritis treatment, tendon treatment, wound healing, nerve regeneration, incontinence, and much more. This Special Issue aims to describe the latest findings in the clinical application of adipose tissue and its stem cells, including original research papers and review articles.

Kind regards,

Prof. Dr. Lukas Prantl
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • adipose stem cells
  • tissue regeneration
  • clinical applications

Related Special Issue

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Review

16 pages, 1232 KiB  
Review
Intra-Articular Application of Autologous, Fat-Derived Orthobiologics in the Treatment of Knee Osteoarthritis: A Systematic Review
by Matthias Holzbauer, Eleni Priglinger, Stig-Frederik Trojahn Kølle, Lukas Prantl, Christian Stadler, Philipp Wilhelm Winkler, Tobias Gotterbarm and Dominik Duscher
Cells 2024, 13(9), 750; https://doi.org/10.3390/cells13090750 - 25 Apr 2024
Viewed by 193
Abstract
The aim of this study was to review the current literature regarding the effects of intra-articularly applied, fat-derived orthobiologics (FDO) in the treatment of primary knee osteoarthritis over a mid-term follow-up period. A systematic literature search was conducted on the online databases of [...] Read more.
The aim of this study was to review the current literature regarding the effects of intra-articularly applied, fat-derived orthobiologics (FDO) in the treatment of primary knee osteoarthritis over a mid-term follow-up period. A systematic literature search was conducted on the online databases of Scopus, PubMed, Ovid MEDLINE, and Cochrane Library. Studies investigating intra-articularly applied FDO with a minimum number of 10 knee osteoarthritis patients, a follow-up period of at least 2 years, and at least 1 reported functional parameter (pain level or Patient-Reported Outcome Measures) were included. Exclusion criteria encompassed focal chondral defects and techniques including additional arthroscopic bone marrow stimulation. In 28 of 29 studies, FDO showed a subjective improvement in symptoms (pain and Patient-Reported Outcome Measures) up to a maximum follow-up of 7.2 years. Radiographic cartilage regeneration up to 3 years postoperatively, as well as macroscopic cartilage regeneration investigated via second-look arthroscopy, may corroborate the favorable clinical findings in patients with knee osteoarthritis. The methodological heterogeneity in FDO treatments leads to variations in cell composition and represents a limitation in the current state of knowledge. However, this systematic review suggests that FDO injection leads to beneficial mid-term results including symptom reduction and preservation of the affected joint in knee osteoarthritis patients. Full article
(This article belongs to the Special Issue Therapeutic Potentials of Adipose-Derived Stem Cells)
►▼ Show Figures

Figure 1

15 pages, 2469 KiB  
Review
The Triple Adipose-Derived Stem Cell Exosome Technology as a Potential Tool for Treating Triple-Negative Breast Cancer
by Andrea Pagani, Dominik Duscher, Sebastian Geis, Silvan Klein, Leonard Knoedler, Adriana C. Panayi, Dmytro Oliinyk, Oliver Felthaus and Lukas Prantl
Cells 2024, 13(7), 614; https://doi.org/10.3390/cells13070614 - 02 Apr 2024
Viewed by 669
Abstract
Background: Extracellular vesicles are pivotal mediators in intercellular communication, facilitating the exchange of biological information among healthy, pathological and tumor cells. Between the diverse subtypes of extracellular vesicles, exosomes have unique properties and clinical and therapeutical applications. Breast cancer ranks as one of [...] Read more.
Background: Extracellular vesicles are pivotal mediators in intercellular communication, facilitating the exchange of biological information among healthy, pathological and tumor cells. Between the diverse subtypes of extracellular vesicles, exosomes have unique properties and clinical and therapeutical applications. Breast cancer ranks as one of the most prevalent malignancies across the globe. Both the tumor core and its surrounding microenvironment engage in a complex, orchestrated interaction that facilitates cancer’s growth and spread. Methods: The most significant PubMed literature about extracellular vesicles and Adipose-Derived Stem Cell Exosomes and breast cancer was selected in order to report their biological properties and potential applications, in particular in treating triple-negative breast cancer. Results: Adipose-Derived Stem Cell Exosomes represent a potential tool in targeting triple-negative breast cancer cells at three main levels: the tumor core, the tumor microenvironment and surrounding tissues, including metastases. Conclusions: The possibility of impacting triple-negative breast cancer cells with engineered Adipose-Derived Stem Cell Exosomes is real. The opportunity to translate our current in vitro analyses into a future in vivo scenario is even more challenging. Full article
(This article belongs to the Special Issue Therapeutic Potentials of Adipose-Derived Stem Cells)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop