Structure and Function of Tight Junctions
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Motility and Adhesion".
Deadline for manuscript submissions: closed (15 November 2023) | Viewed by 14569
Special Issue Editors
Interests: epithelial and endothelial cell biology; cell-cell junctions and adhesion; cell polarity; age-related and inherited retinal disease; neurodegenerative disease; glaucoma
Interests: cell-cell and extracellular adhesion signalling crosstalk; eye biology and physiology; novel targets for therapy of inflammatory and fibrotic diseases, and cancer, as well as proliferative and degenerative eye diseases
Special Issue Information
Dear Colleagues,
Tight junctions are essential for epithelial and endothelial barrier formation. They are cell–cell adhesion complexes with a remarkable abundance of components ranging from cell adhesion proteins through scaffolding proteins and cytoskeletal linkers to different types of signaling proteins that regulate junctional properties as well as cell and tissue functions. As diverse as their components are their functions that include the formation of semipermeable paracellular diffusion barriers, regulation of cell polarization and maintenance of cell surface polarity, modulation of cell and tissue mechanics and morphogenesis, and regulation of gene expression, cell proliferation, and differentiation. Consequently, tight junctions and their components have been linked to multiple inherited, acute, and chronic diseases such as cancer, viral infections, and inflammatory and degenerative conditions.
The purpose of this Special Issue on the structure and function of tight junctions is to emphasize and discuss recent findings on how tight junctions assemble and function in different cell types, and their role in tissue development and morphogenetic processes. The goal of this Special Issue is to cover the entire range of tight junction biology and their roles in disease with research papers and reviews.
Prof. Dr. Karl Matter
Prof. Dr. Maria Balda
Guest Editors
Manuscript Submission Information
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Keywords
- tissue barriers
- mechanotransduction
- cytoskeleton
- cancer
- inflammation
- gene expression
- adhesion
- polarization
- endothelia
- epithelia