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Cells
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Host–Microbiome Interactions in Metabolic Health
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Host–Microbiome Interactions in Metabolic Health

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Metabolism".

Deadline for manuscript submissions: closed (15 December 2022) | Viewed by 6012

Special Issue Editors

Dr. Federica D'Amico

E-Mail Website
Guest Editor
Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy
Interests: gut microbiome; metabolic syndrome; oncology; chemotherapy; infections; antibiotic resistance
Special Issues, Collections and Topics in MDPI journals
Dr. Davide Agnoletti

E-Mail Website
Guest Editor
Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy
Interests: vascular medicine; cardiovascular disease; hypertension; atherosclerosis; metabolic syndrome; arterial stiffness; vascular ageing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear colleagues,

Thousands of different microbial species inhabit the human body, and they have a strategic role in maintaining host homeostasis. In this context, the gut microbiome is one of the most studied and metabolically dynamic ecosystems known for producing a large and diverse repertoire of small bioactive molecules through the metabolism of dietary and host-derived compounds. For these reasons, the gut microbiome has the potential to exert a strong influence on multiple aspects of our physiology, from energy balance and metabolic regulation to the development and functioning of immune, endocrine and nervous systems. The disequilibrium (i.e., dysbiosis) of the gut microbial community has been associated with a higher risk of developing metabolic disorders such as cardiovascular disorders, obesity, type 2 diabetes and nonalcoholic fatty liver disease. However, the mechanisms underlying these connections, as well as the involvement of other microbial ecosystems besides the intestinal one, still need to be investigated through novel approaches, also targeting the in silico, in vitro and in vivo functionality of microbes.

This Special Issue, “Host–Microbiome Interactions in Metabolic Health” will focus on the role of human microbiome in maintaining host metabolic health, as well as the mechanisms underlying the break of microbiome–host homeostatic crosstalk.

Authors are invited to submit original research and review papers addressing the topics of this Special Issue.

Dr. Federica D'Amico
Dr. Davide Agnoletti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbiome
  • gut microbiota
  • metabolic syndrome
  • cardiovascular disease
  • obesity
  • T2D
  • dysbiosis
  • microbiome–host interactions

Published Papers (2 papers)

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20 pages, 4007 KiB  
Article
Gut-Kidney Impairment Process of Adenine Combined with Folium sennae-Induced Diarrhea: Association with Interactions between Lactobacillus intestinalis, Bacteroides acidifaciens and Acetic Acid, Inflammation, and Kidney Function
by Xiaoya Li, Xinxin Peng, Bo Qiao, Maijiao Peng, Na Deng, Rong Yu and Zhoujin Tan
Cells 2022, 11(20), 3261; https://doi.org/10.3390/cells11203261 - 17 Oct 2022
Cited by 10 | Viewed by 1678
Abstract
Background: Extensive evidence suggests that gut microbiota may interact with the kidneys and play central roles in the pathogenesis of disease. However, the association of gut microbiota-kidneys in diarrhea remains unclear. Methods: A diarrhea mouse model was constructed by combining adenine with Folium [...] Read more.
Background: Extensive evidence suggests that gut microbiota may interact with the kidneys and play central roles in the pathogenesis of disease. However, the association of gut microbiota-kidneys in diarrhea remains unclear. Methods: A diarrhea mouse model was constructed by combining adenine with Folium sennae. We analyzed the characteristics of the gut content microbiota and short chain fatty acids (SCFAs); and explored the potential link between gut content microbiota, SCFAs, intestinal inflammatory response and kidney function. Results: Characteristic bacteria Lactobacillus intestinalis and Bacteroides acidifaciens were enriched in the gut contents of mice. The productions of SCFAs were remarkably inhibited. Model mice presented an increased trend of creatinine (Cr), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), a decreased trend of blood urea nitrogen (BUN) and secretory immunoglobulin A (SIgA). The pathological analysis proved obvious damage to the kidney structure. Lactobacillus intestinalis and Bacteroides acidifaciens exisited in the correlations with acetic acid, intestinal inflammatory response and kidney function. Conclusions: Adenine combined with Folium sennae-induced diarrhea, altered the structure and function of the gut content microbiota in mice, causing the enrichment of the characteristic bacteria Lactobacillus intestinalis and Bacteroides acidifaciens. The interactions between Lactobacillus intestinalis, Bacteroides acidifaciens and acetic acid, intestinal inflammation, and kidney function might be involved in the process of gut-kidney impairment in adenine, combined with Folium sennae-induced diarrhea. Full article
(This article belongs to the Special Issue Host–Microbiome Interactions in Metabolic Health)
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14 pages, 24658 KiB  
Hypothesis
Elucidation of Prebiotics, Probiotics, Postbiotics, and Target from Gut Microbiota to Alleviate Obesity via Network Pharmacology Study
by Ki-Kwang Oh, Haripriya Gupta, Byeong-Hyun Min, Raja Ganesan, Satya Priya Sharma, Sung-Min Won, Jin-Ju Jeong, Su-Been Lee, Min-Gi Cha, Goo-Hyun Kwon, Min-Kyo Jeong, Ji-Ye Hyun, Jung-A Eom, Hee-Jin Park, Sang-Jun Yoon, Mi-Ran Choi, Dong Joon Kim and Ki-Tae Suk
Cells 2022, 11(18), 2903; https://doi.org/10.3390/cells11182903 - 16 Sep 2022
Cited by 6 | Viewed by 3964
Abstract
The metabolites produced by the gut microbiota have been reported as crucial agents against obesity; however, their key targets have not been revealed completely in complex microbiome systems. Hence, the aim of this study was to decipher promising prebiotics, probiotics, postbiotics, and more [...] Read more.
The metabolites produced by the gut microbiota have been reported as crucial agents against obesity; however, their key targets have not been revealed completely in complex microbiome systems. Hence, the aim of this study was to decipher promising prebiotics, probiotics, postbiotics, and more importantly, key target(s) via a network pharmacology approach. First, we retrieved the metabolites related to gut microbes from the gutMGene database. Then, we performed a meta-analysis to identify metabolite-related targets via the similarity ensemble approach (SEA) and SwissTargetPrediction (STP), and obesity-related targets were identified by DisGeNET and OMIM databases. After selecting the overlapping targets, we adopted topological analysis to identify core targets against obesity. Furthermore, we employed the integrated networks to microbiota–substrate–metabolite–target (MSMT) via R Package. Finally, we performed a molecular docking test (MDT) to verify the binding affinity between metabolite(s) and target(s) with the Autodock 1.5.6 tool. Based on holistic viewpoints, we performed a filtering step to discover the core targets through topological analysis. Then, we implemented protein–protein interaction (PPI) networks with 342 overlapping target, another subnetwork was constructed with the top 30% degree centrality (DC), and the final core networks were obtained after screening the top 30% betweenness centrality (BC). The final core targets were IL6, AKT1, and ALB. We showed that the three core targets interacted with three other components via the MSMT network in alleviating obesity, i.e., four microbiota, two substrates, and six metabolites. The MDT confirmed that equol (postbiotics) converted from isoflavone (prebiotics) via Lactobacillus paracasei JS1 (probiotics) can bind the most stably on IL6 (target) compared with the other four metabolites (3-indolepropionic acid, trimethylamine oxide, butyrate, and acetate). In this study, we demonstrated that the promising substate (prebiotics), microbe (probiotics), metabolite (postbiotics), and target are suitable for obsesity treatment, providing a microbiome basis for further research. Full article
(This article belongs to the Special Issue Host–Microbiome Interactions in Metabolic Health)
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