Towards the Transition Metal Catalysis in Organic Synthesis, 2nd Edition

A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Catalysis in Organic and Polymer Chemistry".

Deadline for manuscript submissions: closed (15 October 2023) | Viewed by 3086

Special Issue Editor


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Guest Editor
Dipartimento di Scienza e Alta Tecnologia, Università dell’Insubria, Via Valleggio 11, 22100 Como, Italy
Interests: methodologies for the synthesis of heterocyclic compounds by transition metal-catalyzed reactions; C–H functionalization processes involving unactivated carbon–carbon multiple bonds
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Special Issue Information

Dear Colleagues,

Transition metal catalyzed reactions have become powerful tools in organic synthesis because allow the formation of carbon-carbon and carbon-heteroatom bonds in mild and sustainable conditions. The synthetic methodologies that are part of the homogeneous catalysis have a considerable interest also from the applicative point of view, as they facilitate access to organic compounds useful in medicinal chemistry and for the production of new materials with high chemo-, regio-, and stereoselectivity.

The broad scope of this Special Issue would include works focused on the development of new synthetic methodologies based on the use of transition metal catalysts and on the preparation of transition metal complexes more performing in the catalysis of organic reactions. In addition, synthetic protocols of industrial interest as well as theoretical studies aimed at shedding light on the mechanism of action of the catalysts are welcome.

Prof. Dr. Broggini Gianluigi
Guest Editor

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Keywords

  • transition metals
  • homogeneous catalysis
  • organic synthesis
  • asymmetric reactions
  • reaction mechanism

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Published Papers (2 papers)

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Research

12 pages, 1432 KiB  
Article
Rhodium-Catalyzed Alkylation of Aromatic Ketones with Allylic Alcohols and α,β-Unsaturated Ketones
by Wan-Di Li, Jia-Shuo Zhang, Lin-Yan Zhang, Zhong-Wen Liu, Juan Fan and Xian-Ying Shi
Catalysts 2023, 13(8), 1157; https://doi.org/10.3390/catal13081157 - 26 Jul 2023
Cited by 2 | Viewed by 964
Abstract
The direct transition-metal-catalyzed addition of C–H bonds to unsaturated C=X (X=C, O, and N) bonds via C–H bond activation has been recognized as a powerful tool for the construction of C–C bonds (in terms of atom and step economy). Herein, the direct rhodium-catalyzed [...] Read more.
The direct transition-metal-catalyzed addition of C–H bonds to unsaturated C=X (X=C, O, and N) bonds via C–H bond activation has been recognized as a powerful tool for the construction of C–C bonds (in terms of atom and step economy). Herein, the direct rhodium-catalyzed C–H bond addition of aromatic ketones to allylic alcohols and α,β-unsaturated ketones that affords β-aryl carbonyl compounds is described, in which a ketone carbonyl acts as a weakly coordinating directing group. It was found that the type of alkyl in aromatic ketones is crucial for the success of the reaction. This transformation provides a convenient and efficient methodology for the synthesis of 2-alkyl aromatic ketones in moderate-to-excellent yields. Full article
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16 pages, 5983 KiB  
Article
Development of a Graphene Oxide-Supported N-Heterocyclic Carbene Copper(I) Complex as a Heterogeneous Catalyst for the Selective N-Monoalkylation of Amines
by Shelly Kujur, Shruti Verma and Devendra Deo Pathak
Catalysts 2022, 12(11), 1458; https://doi.org/10.3390/catal12111458 - 17 Nov 2022
Cited by 2 | Viewed by 1693
Abstract
A new N-heterocyclic carbene (NHC) copper(I) complex supported on graphene oxide (GO-NHC-Cu) was synthesised and thoroughly characterised by various instrumental techniques such as FT-IR, FT-Raman, PXRD, XPS, FESEM, EDX, HRTEM, TGA and ICP-OES. The catalytic activity of the supported complex was explored [...] Read more.
A new N-heterocyclic carbene (NHC) copper(I) complex supported on graphene oxide (GO-NHC-Cu) was synthesised and thoroughly characterised by various instrumental techniques such as FT-IR, FT-Raman, PXRD, XPS, FESEM, EDX, HRTEM, TGA and ICP-OES. The catalytic activity of the supported complex was explored in the N-alkylation of anilines with alcohols under solvent-free and aerobic conditions to afford monoalkylated products in good to excellent yields (20 products, 83–96%). All products were isolated and characterised by 1H and 13C{1H} NMR spectroscopy. The catalyst was recuperated from the reaction mixture by simple filtration and reused for up to five successive cycles with insignificant loss in the catalytic activity. The control experiments showed that the reaction proceeded in aerobic conditions. The green chemistry metrics for the reaction were found to be fairly close to the ideal values: carbon efficiency (95.9%), E-factor (0.15), atom economy (92.14%), process mass intensity (1.15) and reaction mass efficiency (86.80%). The air stability, selectivity, recyclability of the catalyst, and the high yields of the products under solvent-free conditions are some of the salient features of the reported methodology. Full article
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