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Brain Sciences
Special Issues
Neural Signaling and Synaptic Transmission
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Neural Signaling and Synaptic Transmission

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Molecular and Cellular Neuroscience".

Deadline for manuscript submissions: closed (28 February 2020) | Viewed by 6452

Special Issue Editor

Prof. Dr. Thomas Heinbockel

E-Mail Website1 Website2
Guest Editor
Department of Anatomy, College of Medicine, Howard University, Washington, DC 20059, USA
Interests: translational medicine; drug discovery; public health; neural signaling and synaptic transmission in the central nervous system; functional organization of the olfactory and limbic system; cellular and network mechanisms of brain function and dysfunction studied with electrophysiological, optical, anatomical, and pharmacological methods
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue will publish contributions about innovative experimental approaches and novel findings in the field of Neural Signaling and Synaptic Transmission. Reviews providing a fresh perspective on the existing literature are also welcome. Neural signaling and synaptic transmission is an overriding theme of brain research in order to understand the nervous system in its function and dysfunction. For the past several decades, researchers have attempted and succeeded in deciphering molecular and cellular synaptic changes that are the basis for behavior and brain disease. However, even though our understanding of synaptic transmission and plasticity has grown tremendously, pivotal questions regarding neural signaling and plasticity remain. Technical advances in neuroscience research are a major catalyst for progress in Neural Signaling and Synaptic Transmission. Among these advances are genetic, optical, and optogenetic methods that allow researchers to manipulate single cells or neural circuits with subcellular precision, at microsecond timescales or through longitudinal electrophysiological and optical recordings. New experimental and conceptual approaches will pave the way to a more complete understanding of the functional consequences of Neural Signaling and Synaptic Transmission and its implications for health and disease. This Special Issue will provide insights into a range of issues related to Neural Signaling and Synaptic Transmission and will capture the exciting developments in the field. This Special Issue will contribute to our understanding of Neural Signaling and Synaptic Transmission ranging from molecular, biochemical, and cellular mechanisms to circuit, systems, and behavioral phenomena and will inform the reader about their clinical relevance.

Prof. Dr. Thomas Heinbockel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Neural signaling
  • Neural circuit
  • Synapse
  • Synaptic transmission
  • Synaptic plasticity
  • Optogenetics
  • Electrophysiology
  • Optical recording
  • Brain disease

Published Papers (1 paper)

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Research

13 pages, 1253 KiB  
Article
Role of Potassium Ions Quantum Tunneling in the Pathophysiology of Phantom Limb Pain
by Mustafa Alrabayah, Abdallah Barjas Qaswal, Aiman Suleiman and Lubna Khreesha
Brain Sci. 2020, 10(4), 241; https://doi.org/10.3390/brainsci10040241 - 18 Apr 2020
Cited by 5 | Viewed by 6107
Abstract
(1) Background: multiple theories were proposed to explain the phenomenon of phantom limb pain (PLP). Nevertheless, the phenomenon is still shrouded in mystery. The aim of this study is to explore the phenomenon from a new perspective, where quantum tunneling of ions, a [...] Read more.
(1) Background: multiple theories were proposed to explain the phenomenon of phantom limb pain (PLP). Nevertheless, the phenomenon is still shrouded in mystery. The aim of this study is to explore the phenomenon from a new perspective, where quantum tunneling of ions, a promising field in medical practice, might play a major role. (2) Methods: investigators designed a quantum mathematical model based on the Schrödinger equation to examine the probability of potassium ions quantum tunneling through closed membrane potassium channels to the inside of phantom axons, leading to the generation of action potential. (3) Results: the model suggests that the probability of action potential induction at a certain region of the membrane of phantom neurons, when a neuron of the stump area is stimulated over 1 mm2 surface area of the membrane available for tunneling is 1.04 × 10−2. Furthermore, upon considering two probabilities of potassium channelopathies, one that decreased the energy of the barrier by 25% and another one by 50%, the tunneling probability became 1.22 × 10−8 and 3.86 × 10−4, respectively. (4) Conclusion: quantum models of potassium ions can provide a reliable theoretical hypothesis to unveil part of the ambiguity behind PLP. Full article
(This article belongs to the Special Issue Neural Signaling and Synaptic Transmission)
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