Role of Astrocytes and Microglia in the Mediation of Neuroinflammatory Process in Neurodegenerative Diseases and Novel Therapeutic Approaches
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuroglia".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 2248
Special Issue Editors
Interests: neuroinflammation; Alzheimer’s diseases; Parkinson’s disease; stress and addiction; neuroinflammation in alcoholism and therapeutic approaches
Interests: immunology; neuroimmunology; cancer immunology; immunotherapy; NK and T cell biology
Interests: neuroscience; nanotechnology; neuroinflammation in epilepsy
Interests: neuroglial-neuronal metabolic crosstalk; protein aggregation and propagation in neu-rodegenerative diseases; Alzheimer’s disease; Parkinson’s disease; traumatic brain in-jury; frontotemporal dementia; HIV and SARS-CoV-2 as-sociated neurodegeneration; steady state and isotope labeled metabolomics; single cell and spatial transcriptomics; human iPSC derived cerebral organoid
Special Issue Information
Dear Colleagues,
Despite the involvement of diverse protein aggregates and different mechanisms, the most prevalent neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson disease (PD), Huntington’s disease (HD), and traumatic brain injury (TBI) all have one crucial and common pathological driver, i.e., neuroinflammation. In the last decade, numerous findings have demonstrated a predominant contribution of neuroglia in facilitating inflammatory processes in the central nervous system (CNS). In particular, astrocytes and microglia, among other neuroglia, are the major players in these neuroinflammatory processes. Interestingly, activation of astrocytes and microglia is bimodal: it can either be protective until a threshold, or trigger a devastating cascade of neurodegeneration if above the threshold. The challenge is to identify the factors controlling the fine balance between these protective and deleterious effects, and to design novel therapies to address both these effects.
Hence, the aim and scope of this Special Issue are to explore clinical and mechanistic studies that help us gain novel insights into the role of astrocytes and microglia in neurodegenerative diseases, and to report promising therapies targeting neuroinflammation.
This Special Issue welcomes fundamental studies using animal, cell culture, and human iPSC-derived organoid models, as well as biomarker studies using advanced multi-omics tools such as metabolomics, and single-cell and spatial transcriptomics. In this Special Issue, we also welcome review manuscripts, clinical studies, and research articles that update the readers on promising drug targets and therapies for attenuating neuroinflammation. We hope this topic will bring together those who are working in neuroinflammation and neurodegenerative disorders and will be beneficial for both clinicians and scientists.
Dr. Muthuraju Sangu
Dr. Kiran Kundu
Prof. Dr. Kuttulebbai Nainamohamed Salam Sirajudeen
Dr. Tirthankar Sinha
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
