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Biosensors
Special Issues
Nanoengineering for Advanced Biosensors
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Nanoengineering for Advanced Biosensors

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 4855

Special Issue Editor

Prof. Dr. Makusu Tsutsui

E-Mail Website
Guest Editor
The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan
Interests: single-molecule sequencing using nanopores and nanoelectrodes; machine-learning-enhanced resistive pulse analyses; integrated nanopore sensors; ion and mass transport in functionalized nanopores and nanochannels
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biosensors are playing pivotal roles in advancing our knowledge about life and managing public health. In recent years, nanotechnology has revolutionized these sensors in terms of their sensitivity and throughput by allowing the nanoengineering of transducers and biorecognition molecules to spur innovative strategies for addressing biological events at unprecedented spatial resolutions, sometimes even in real time and space.

This Special Issue aims to showcase cutting-edge research and reviews on nanotechnology-enabled biosensors on topics including, but not limited to, the following:

  • New receptor molecules for advanced biosensors;
  • Ultrasensitive MEMS/NEMS biosensors;
  • Materials and designs of nanomaterials for advanced biosensors;
  • Nanotechnology-enabled lab-on-a-chip sensor systems.

Prof. Dr. Makusu Tsutsui
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • MEMS/NEMS
  • nanomaterials
  • nano-bio interfaces
  • receptors
  • diagnosis

Published Papers (2 papers)

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Research

15 pages, 10515 KiB  
Article
Highly Heterogeneous Morphology of Cobalt Oxide Nanostructures for the Development of Sensitive and Selective Ascorbic Acid Non-Enzymatic Sensor
by Abdul Sattar Chang, Aneela Tahira, Fouzia Chang, Abdul Ghaffar Solangi, Muhammad Ali Bhatti, Brigitte Vigolo, Ayman Nafady and Zafar Hussain Ibupoto
Biosensors 2023, 13(1), 147; https://doi.org/10.3390/bios13010147 - 16 Jan 2023
Cited by 7 | Viewed by 2744
Abstract
The surface tailored metal oxide nanostructures for the development of non-enzymatic sensors are highly demanded, but it is a big task due to the wide range of complexities during the growth process. The presented study focused on the surface modification of the heterogeneous [...] Read more.
The surface tailored metal oxide nanostructures for the development of non-enzymatic sensors are highly demanded, but it is a big task due to the wide range of complexities during the growth process. The presented study focused on the surface modification of the heterogeneous morphology of cobalt oxide (Co3O4) prepared by the hydrothermal method. Further surface modification was conducted with the use of sodium citrate as a reducing and surface modifying agent for the Co3O4 nanostructures through the high density of oxygenated terminal groups from the citrate ions. The citrate ions enabled a significant surface modification of the Co3O4 nanostructures, which further improved the electrochemical properties of the Co3O4 material toward the design of the non-enzymatic ascorbic acid sensor in a phosphate buffer solution of pH 7.4. The morphology and crystal arrays of the Co3O4 nanostructures were studied by scanning electron microscopy (SEM) and powder X-ray diffraction (XRD) techniques. These physical characterizations showed the highly tailored surface features of Co3O4 nanostructures and a significant impact on the crystal properties. The electrochemical activity of Co3O4 was studied by chronoamperometry, linear sweep voltammetry, and cyclic voltammetry (CV) for the detection of ascorbic acid. The linear range of the proposed sensor was measured from 0.5 mM to 6.5 mM and a low limit of detection of 0.001 mM was also estimated. The presented Co3O4 nanostructures exhibited significant surface roughness and surface area, consequently playing a vital role toward the selective, sensitive, and stable detection of ascorbic acid. The use of a low cost surface modifying agent such as sodium citrate could be of great interest for the surface roughness and high surface area of nanostructured materials for the improved electrochemical properties for the biomedical, energy storage, and conversion systems. Full article
(This article belongs to the Special Issue Nanoengineering for Advanced Biosensors)
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16 pages, 5058 KiB  
Article
Kinetics of Drug Molecule Interactions with a Newly Developed Nano-Gold-Modified Spike Protein Electrochemical Receptor Sensor
by Dingqiang Lu, Danyang Liu, Xinqian Wang, Yujiao Liu, Yixuan Liu, Ruijuan Ren and Guangchang Pang
Biosensors 2022, 12(10), 888; https://doi.org/10.3390/bios12100888 - 17 Oct 2022
Cited by 1 | Viewed by 1720
Abstract
In March 2020, the World Health Organization (WHO) declared COVID-19 a pandemic, and the spike protein has been reported to be an important drug target for anti-COVID-19 treatment. As such, in this study, we successfully developed a novel electrochemical receptor biosensor by immobilizing [...] Read more.
In March 2020, the World Health Organization (WHO) declared COVID-19 a pandemic, and the spike protein has been reported to be an important drug target for anti-COVID-19 treatment. As such, in this study, we successfully developed a novel electrochemical receptor biosensor by immobilizing the SARS-CoV-2 spike protein and using AuNPs-HRP as an electrochemical signal amplification system. Moreover, the time-current method was used to quantify seven antiviral drug compounds, such as arbidol and chloroquine diphosphate. The results show that the spike protein and the drugs are linearly correlated within a certain concentration range and that the detection sensitivity of the sensor is extremely high. In the low concentration range of linear response, the kinetics of receptor–ligand interactions are similar to that of an enzymatic reaction. Among the investigated drug molecules, bromhexine exhibits the smallest Ka value, and thus, is most sensitively detected by the sensor. Hydroxychloroquine exhibits the largest Ka value. Molecular docking simulations of the spike protein with six small-molecule drugs show that residues of this protein, such as Asp, Trp, Asn, and Gln, form hydrogen bonds with the -OH or -NH2 groups on the branched chains of small-molecule drugs. The electrochemical receptor biosensor can directly quantify the interaction between the spike protein and drugs such as abidor and hydroxychloroquine and perform kinetic studies with a limit of detection 3.3 × 10−20 mol/L, which provides a new research method and idea for receptor–ligand interactions and pharmacodynamic evaluation. Full article
(This article belongs to the Special Issue Nanoengineering for Advanced Biosensors)
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