Microfluidic Biochips and Their Biomedical Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1774

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Guest Editor
Research Center for Applied Sciences, Academia Sinica, Taipei 11529, Taiwan
Interests: cell-based microanalysis; electrotaxis; microfluidic biochip development and applications; microarray technologies; laser micro machining
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Special Issue Information

Dear Colleagues,

In recent decades, microfluidic biochips have been used in numerous applications for biomedical research, including, but not limited to, organ-on-a-chip technologies, microscale flow control, microfluidic biosensors, droplet generation, drug delivery, DNA analysis, immunoassays, cell culturing, single-cell analysis, pathogen detection (viruses and bacteria), flow cytometry, bioprinting, tissue engineering, separation techniques, bioanalytical systems, etc.

Microfluidic biochips have revolutionized the way biomedical research is conducted and have expedited the pace of the research. They have also brought fundamental researchers closer to practical applications.

We cordially invite you to submit groundbreaking research papers to this Special Issue on the biomedical applications of microfluidic chips. We are seeking original and innovative contributions with this focus. This is an excellent opportunity for you to share your latest findings, advancements, and insights with the active scientific community.

This Special Issue aims to foster interdisciplinary collaboration and promote cutting-edge research on the application of microfluidic devices. We encourage submissions about a diverse range of applications. Whether your research focuses on fundamental principles or practical applications, we welcome your valuable contribution.

Prof. Dr. Ji-Yen Cheng
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • microfluidic biosensors
  • microfluidic drug delivery
  • microfluidic biomolecule analysis
  • cell culturing and single-cell analysis
  • bioprinting
  • tissue engineering
  • separation techniques

Published Papers (1 paper)

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Research

12 pages, 1631 KiB  
Article
Irregular Antibody Screening Using a Microdroplet Platform
by Ding-Ping Chen, Pei-Yu Wu and Yen-Heng Lin
Biosensors 2023, 13(9), 869; https://doi.org/10.3390/bios13090869 - 04 Sep 2023
Viewed by 1463
Abstract
The screening procedure for antibodies is considered the most tedious among the three pretransfusion operations, i.e., ABO and Rhesus (Rh) typing, irregular antibody screening/identification, and crossmatching tests. The commonly used screening method for irregular antibodies in clinics at present is a manual polybrene [...] Read more.
The screening procedure for antibodies is considered the most tedious among the three pretransfusion operations, i.e., ABO and Rhesus (Rh) typing, irregular antibody screening/identification, and crossmatching tests. The commonly used screening method for irregular antibodies in clinics at present is a manual polybrene test (MP). The MP test involves numerous reagent replacement and centrifuge procedures, and the sample volume is expected to be relatively less. Herein, screening red blood cells (RBCs) and serum irregular antibodies are encapsulated in microdroplets with a diameter of ~300 μm for a hemagglutination reaction. Owing to the advantage of spatial limitation in microdroplets, screening RBCs and irregular antibodies can be directly agglutinated, thereby eliminating the need for centrifugation and the addition of reagents to promote agglutination, as required by the MP method. Furthermore, the results for a large number of repeated tests can be concurrently obtained, further simplifying the steps of irregular antibody screening and increasing accuracy. Eight irregular antibodies are screened using the proposed platform, and the results are consistent with the MP method. Moreover, the volume of blood samples and antibodies can be reduced to 10 μL and 5 μL, respectively, which is ten times less than that using the MP method. Full article
(This article belongs to the Special Issue Microfluidic Biochips and Their Biomedical Applications)
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