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Integrated Microfluidic Microarray Biochip and Biosensor

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (1 May 2021) | Viewed by 2892

Special Issue Editors

Research Center for Applied Sciences, Academia Sinica, Taipei 11529, Taiwan
Interests: cell-based microanalysis; electrotaxis; microfluidic biochip development and applications; microarray technologies; laser micro machining
Special Issues, Collections and Topics in MDPI journals
National Heart Centre Singapore, 5 Hospital Drive, Singapore 169609, Singapore
Interests: microfluidics; 3D cell cultures; human-on-a-chip; lab automation; biomedical engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microarray is a concept implementing multiple probes for a high-throughput parallel analysis. Over the two decades since the invention of the concept, several types of probes, ranging from small molecules, oligonucleotides, antibodies, proteins, and even whole organisms, such as viruses (e.g., bacteriophage), bacteria cells, and mammalian cells, have been utilized for high-throughput sensing in various types of research, such as biosensing and molecular biology studies. When integrated with microfluidic devices, the microarray technique becomes more powerful by reducing the reagent consumption and reaction time, with precise control of the microenvironment, and having a higher compatibility with the automated operation. This Issue intends to cover the technology involved in the integration of microarray and microfluidics, and the benefits/applications made possible by the integration.

Prof. Dr. Ji-Yen Cheng
Prof. Dr. Danny van Noort
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Small compound array
  • Oligonucleotide microarray
  • Bacteriophage
  • DNA microarray
  • Antibody array
  • Protein microarray
  • Whole-cell array
  • Microarray in microchannel
  • Microfluidic flow
  • Microcontrolled environment
  • Biosensing

Published Papers (1 paper)

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Research

13 pages, 4057 KiB  
Article
Fully Automated Lab-On-A-Disc Platform for Loop-Mediated Isothermal Amplification Using Micro-Carbon-Activated Cell Lysis
Sensors 2020, 20(17), 4746; https://doi.org/10.3390/s20174746 - 22 Aug 2020
Cited by 5 | Viewed by 2500
Abstract
Fast and fully automated deoxyribonucleic acid (DNA) amplification methods are of interest in the research on lab-on-a-disc (LOD) platforms because of their full compatibility with the spin-column mechanism using centrifugal force. However, the standard procedures followed in DNA amplification require accurate noncontact temperature [...] Read more.
Fast and fully automated deoxyribonucleic acid (DNA) amplification methods are of interest in the research on lab-on-a-disc (LOD) platforms because of their full compatibility with the spin-column mechanism using centrifugal force. However, the standard procedures followed in DNA amplification require accurate noncontact temperature control as well as cell lysis at a low temperature to prevent damage to the LOD platform. This requirement makes it challenging to achieve full automation of DNA amplification on an LOD. In this paper, a fully automated LOD capable of performing cell lysis and amplification on a single compact disc of DNA samples is proposed. The proposed system uses micro-carbon to heat DNA samples without damaging the LOD as well as a noncontact heating system and an infrared camera sensor to remotely measure the real temperature of the amplification chamber. Compared with conventional DNA amplification systems, the proposed system has the advantage of full automation of the LOD platform. Experimental results demonstrated that the proposed system offers a stable heating method for DNA amplification and cell lysis. Full article
(This article belongs to the Special Issue Integrated Microfluidic Microarray Biochip and Biosensor)
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