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Nano-Structure Modified Biomaterial
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Nano-Structure Modified Biomaterial

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Nanotechnology and Applied Nanosciences".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 1935

Special Issue Editors

Prof. Dr. Tohru Sekino

E-Mail Website
Guest Editor
Department of advanced hard materials, The Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka 8-1, Osaka 567-0047, Japan
Interests: ceramics; nanostructured materials; multifunctions; hybrid materials; structure-function relations
Special Issues, Collections and Topics in MDPI journals
Dr. Satoshi Komasa

E-Mail Website
Guest Editor
Department of Removable Prosthodontics and Occlusion, Osaka Dental University, 8-1, Kuzuhahanazono-cho, Hirakata-shi 573-1121, Osaka, Japan
Interests: implant; titanium; zirconia; PEEK; HA coating; nano structure; bacteria
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Yoshiro Tahara

E-Mail Website
Guest Editor
Faculty of Science and Engineering, Doshisha University, 1-3 Tatara Miyakodani, Kyoto 610-0394, Japan
Interests: drug delivery; biomaterials; vaccine; tissue engineering; transdermal delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, implant treatment has become an indispensable option for the treatment of tooth defects. To shorten the treatment period, which is one of the problems of implant treatment, the surface of various implant materials is being modified worldwide. Currently, research is underway on bone differentiation and surface modification for the attachment of periodontal tissue and soft tissue, but, the goal of research on the modification of implant material has not yet been reached. Therefore, in this section, we would like to call for papers on various research themes focusing on nanostructure control of the material surface.

Prof. Dr. Tohru Sekino
Dr. Satoshi Komasa
Prof. Dr. Yoshiro Tahara
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nanostructure
  • Implant Material
  • Titanium
  • Zirconia
  • Peek
  • In Vitro Test

Published Papers (1 paper)

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Research

15 pages, 10731 KiB  
Article
Bone Regeneration by Dedifferentiated Fat Cells Using Composite Sponge of Alfa-Tricalcium Phosphate and Gelatin in a Rat Calvarial Defect Model
by Nobuhito Tsumano, Hirohito Kubo, Rie Imataki, Yoshitomo Honda, Yoshiya Hashimoto and Masahiro Nakajima
Appl. Sci. 2021, 11(24), 11941; https://doi.org/10.3390/app112411941 - 15 Dec 2021
Cited by 3 | Viewed by 1524
Abstract
Mechanical and resorbable scaffolds are in high demand for stem cell-based regenerative medicine, to treat refractory bone defects in craniofacial abnormalities and injuries. Multipotent progenitor cells, such as dedifferentiated fat (DFAT) cells, are prospective sources for regenerative therapies. Herein, we aimed to demonstrate [...] Read more.
Mechanical and resorbable scaffolds are in high demand for stem cell-based regenerative medicine, to treat refractory bone defects in craniofacial abnormalities and injuries. Multipotent progenitor cells, such as dedifferentiated fat (DFAT) cells, are prospective sources for regenerative therapies. Herein, we aimed to demonstrate that a composite gelatin sponge (α-TCP/GS) of alfa-tricalcium phosphate (α-TCP) mixed with gelatin scaffolds (GS), with/without DFATs, induced bone regeneration in a rat calvarial defect model in vivo. α-TCP/GS was prepared by mixing α-TCP and 2% GS using vacuum-heated methods. α-TCP/GS samples with/without DFATs were transplanted into the model. After 4 weeks of implantation, the samples were subjected to micro-computed tomography (μ-CT) and histological analysis. α-TCP/GS possessed adequate mechanical strength; α-TCP did not convert to hydroxyapatite upon contact with water, as determined by X-ray diffraction. Moreover, stable α-TCP/GS was formed by electrostatic interactions, and verified based on the infrared peak shifts. μ-CT analyses showed that bone formation was higher in the α-TCP/GS+ DFAT group than in the α-TCP/GS group. Therefore, the implantation of α-TCP/GS comprising DFAT cells enhanced bone regeneration and vascularization, demonstrating the potential for healing critical-sized bone defects. Full article
(This article belongs to the Special Issue Nano-Structure Modified Biomaterial)
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