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Applied Sciences
Special Issues
Emerging Technologies and Innovations for Gut Microbiome Research
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Emerging Technologies and Innovations for Gut Microbiome Research

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Microbiology".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 5140

Special Issue Editors

Prof. Dr. Yiannis Kourkoutas

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Guest Editor
Laboratory of Applied Microbiology & Biotechnology, Department of Molecular Biology & Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece
Interests: food microbiome; functional foods; nutrition; fermentation; antimicrobials
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Eugenia Bezirtzoglou

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Guest Editor
Laboratory of Hygiene and Environmental Protection, Department of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece
Interests: microbiome; antimicrobials; antibiotics; biofilms
Special Issues, Collections and Topics in MDPI journals
Dr. Christina Tsigalou

E-Mail Website
Guest Editor
Laboratory of Microbiology, Department of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece
Interests: immunology; autoimmunity; diet; microbiome; functional foods; antimicrobials
Special Issues, Collections and Topics in MDPI journals
Dr. Gregoria Mitropoulou

E-Mail Website
Guest Editor
Department of Molecular Biology & Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece
Interests: biopreservation; antimicrobials; essential oils; plant extracts; functional cultures; food & gut microbiome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

An increased interest in microbiome application technologies and innovations for maintenance of digestive health is witnessed today. Intestinal microbiome changes may not only act as a diagnostic tool for potential gut disorders, but could also contribute to maintenance of digestive health and overall well-being. Thus, a nutrition based on daily intake of dietary products that stimulate a healthy gut microbiome homeostasis, crowding out harmful microbes, is expected to reinforce the body’s natural defense mechanisms.

However, the current research challenge is also moving beyond digestive health. There is a large body of evidence supporting the concept that the maintenance of a healthy gut microbiome provides protection against a range of health problems, ranging from local gastro-intestinal disorders to neurological, respiratory, cardiovascular, and even mental illnesses.

The aim of this Special Issue is to highlight the emerging technologies and innovation for gut microbiome research. It takes, hence, the opportunity to look inside, as well as beyond the gut, discussing microbiome advancements and applications associated with digestive health and disease, but also with areas away from the gut, like the brain, sleep, mood and depression.

Original research and review articles to be published will include but are not limited to:

  • Gut Microbiome and digestive health;
  • Digestive health innovations, nutrition and disease prevention;
  • Functional foods and gut microbiome;
  • The microbiome-gut-brain axis;
  • Smart food-grade vehicles for targeted delivery of beneficial microbes.

The conjunct Special Issue in Microbiology Research: Emerging Technologies and Innovations for Gut Microbiome Research

Dr. Yiannis Kourkoutas
Prof. Dr. Eugenia Bezirtzoglou
Dr. Christina Tsigalou
Dr. Gregoria Mitropoulou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Dr. Yiannis Kourkoutas
Prof. Dr. Eugenia Bezirtzoglou
Dr. Christina Tsigalou
Dr. Gregoria Mitropoulou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut microbiome
  • microbiome applications
  • digestive health
  • gastro-intestinal disorders
  • microbiome&ndash
  • gut-brain axis
  • functional foods
  • probiotics
  • prebiotics
  • symbiotics
  • postbiotics

Published Papers (2 papers)

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Research

13 pages, 307 KiB  
Article
Developing Stable Freeze-Dried Functional Ingredients Containing Wild-Type Presumptive Probiotic Strains for Food Systems
by Ioanna Prapa, Anastasios Nikolaou, Panayiotis Panas, Chrysoula Tassou and Yiannis Kourkoutas
Appl. Sci. 2023, 13(1), 630; https://doi.org/10.3390/app13010630 - 03 Jan 2023
Cited by 4 | Viewed by 1825
Abstract
Designing stable dried functional food ingredients and foods containing live probiotic cultures maintaining high viable cell loads at the time of consumption is a challenge for the industry. The aim of the present study was the development of stable freeze-dried functional food ingredients [...] Read more.
Designing stable dried functional food ingredients and foods containing live probiotic cultures maintaining high viable cell loads at the time of consumption is a challenge for the industry. The aim of the present study was the development of stable freeze-dried functional food ingredients with enhanced shelf-life during long storage. Zea flakes, pistachios, and raisins were used as immobilization supports for the wild-type presumptive probiotic strains Pediococcus acidilactici SK and Lactiplantibacillus plantarum F4, while L. plantarum B282 was used as a reference strain. Cell survival was monitored during storage at room and refrigerated temperatures for up to 6 months. Levels of freeze-dried cultures were maintained up to 7.2 logcfu/g after 6 months storage at room temperature and up to 8.5 logcfu/g at refrigerator temperature, in contrast to free cell levels that ranged <7 logcfu/mL, suggesting the positive effects of immobilization and freeze-drying on cell viability. Of note, levels of freeze-dried immobilized P. acidilactici SK cells on zea flakes and pistachios remained stable after 6 months of storage at 4 °C, ranging 8.1–8.5 logcfu/g (survival rates 98.2 and 99.7%, respectively). The technology developed presents important advantages for the maintenance of cell viability during storage, assuring stability of ready-to-use functional food ingredients that could be directly incorporated in food systems. Full article
(This article belongs to the Special Issue Emerging Technologies and Innovations for Gut Microbiome Research)
13 pages, 1285 KiB  
Article
Dietary Pistachio (Pistacia vera L.) Beneficially Alters Fatty Acid Profiles in Streptozotocin-Induced Diabetic Rat
by Ioanna Prapa, Amalia E. Yanni, Anastasios Nikolaou, Nikolaos Kostomitsopoulos, Nick Kalogeropoulos, Eugenia Bezirtzoglou, Vaios T. Karathanos and Yiannis Kourkoutas
Appl. Sci. 2022, 12(9), 4606; https://doi.org/10.3390/app12094606 - 03 May 2022
Cited by 4 | Viewed by 1866
Abstract
Type 1 Diabetes (T1D) onset has been associated with diet, among other environmental factors. Adipose tissue and the gut have an impact on β-cell biology, influencing their function. Dietary ingredients affect fatty acid profiles of visceral adipose tissue (VAT) and plasma, as well [...] Read more.
Type 1 Diabetes (T1D) onset has been associated with diet, among other environmental factors. Adipose tissue and the gut have an impact on β-cell biology, influencing their function. Dietary ingredients affect fatty acid profiles of visceral adipose tissue (VAT) and plasma, as well as SCFAs production after microbial fermentation. Pistachios are a rich source of oleic acid, known for their anti-inflammatory actions and favorably affect gut microbiota composition. The purpose of the study was to examine plasma and VAT fatty acids profiles as well as fecal SCFAs after dietary intervention with pistachio nuts in streptozotocin-induced diabetic rats. Plasma and VAT fatty acids were determined by GC-MS and SCFAs by HPLC. After 4 weeks of pistachio consumption, MUFA and especially oleic acid were increased in plasma and VAT of diabetic rats while PUFA, total ω6 and especially 18:2ω6, were decreased. Lactic acid, the major end-product of beneficial intestinal microorganisms, such as lactobacilli, was elevated in healthy groups, while decreased levels of isovaleric acid were recorded in healthy and diabetic groups following the pistachio diet. Our results reveal possible beneficial relationships between pistachio nut consumption, lipid profiles and intestinal health in the disease state of T1D. Full article
(This article belongs to the Special Issue Emerging Technologies and Innovations for Gut Microbiome Research)
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