Nrf2 in Dermatological Pathologies

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: closed (30 September 2018) | Viewed by 14881

Special Issue Editors

ZIK plasmatis, Leibniz Institute for Plasma Science and Technology, Greifswald, Germany
Interests: redox medicine; cold physical plasma; reactive oxygen and nitrogen species; redox signaling; wound healing; dermatology
Special Issues, Collections and Topics in MDPI journals
ZIK Plasmatis, Leibniz Institute for Plasma Science and Technology, Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany
Interests: redox medicine; immunology; cancer; cold physical plasma; reactive oxygen and nitrogen species; redox signaling
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This is to announce a forthcoming Special Issue of the journal Antioxidants on the topic “Nrf2 in Dermatological Pathologies”. Skin diseases, such as psoriasis, skin cancers, or chronic wounds, affects millions of people worldwide, and are strong burdens to patients and health care systems. Skin as the largest body organ serve as important environmental and protection barrier against noxae. A broad spectrum of insults are dermatological toxic by catalyzing the production of reactive oxygen species (ROS) and induction of detrimental redox signaling. An overproduction of ROS can mediate cellular damage of biomolecules, opening of cell junctions, inhibition of migration, alteration of survival and apoptotic signals, and activation of pro-inflammatory responses which are mostly contra-protective for a therapeutic intervention. However, ROS also display hormesis like effects in physiological processes, cellular signal transduction, and immune responses. Essential functions are linked to the activation of the transcription factor Nrf2. Numerous studies show its crucial role in skin protection under oxidative conditions. Further exploration of detailed mechanisms of Nrf2 and down-stream signaling and its therapeutic consequences are the subject of intensive research and will be the content of the forthcoming Special Issue.

We invite both high-quality original articles, as well as reviews, from the whole research area that stimulate and contribute to a deeper understanding of Nrf2 in skin diseases, as well as of biochemical and molecular processes in living systems. Potential topics include, but are not limited to the following:

  • Dermatological diseases, cancers, chronic wounds etc.
  • Pharmacological use of Nrf2 activators
  • Structural, functional, biochemical, and molecular oxidative stress-related effects in in vitro and in vivo studies
  • Influence of reactive species on cellular and molecular responses during therapeutic processes
  • Role of stimuli showing anti-oxidant characteristics
  • Mechanisms of action of novel therapeutics
  • Prevention and management of diseases

Authors can submit their manuscripts through the Manuscript Tracking System at https://susy.mdpi.com/user/manuscripts/upload?journal=antioxidants. Manuscripts are published upon acceptance, regardless of the Special Issue publication date.

Dr. Anke Schmidt
Dr. Sander Bekeschus
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nrf2
  • Redox signaling
  • Skin diseases
  • Reactive oxygen species (ROS)
  • Wound healing
  • Cancer

Published Papers (3 papers)

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Research

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16 pages, 2234 KiB  
Article
Hmox1 Upregulation Is a Mutual Marker in Human Tumor Cells Exposed to Physical Plasma-Derived Oxidants
Antioxidants 2018, 7(11), 151; https://doi.org/10.3390/antiox7110151 - 27 Oct 2018
Cited by 25 | Viewed by 3505
Abstract
Increasing numbers of cancer deaths worldwide demand for new treatment avenues. Cold physical plasma is a partially ionized gas expelling a variety of reactive oxygen and nitrogen species, which can be harnesses therapeutically. Plasmas and plasma-treated liquids have antitumor properties in vitro and [...] Read more.
Increasing numbers of cancer deaths worldwide demand for new treatment avenues. Cold physical plasma is a partially ionized gas expelling a variety of reactive oxygen and nitrogen species, which can be harnesses therapeutically. Plasmas and plasma-treated liquids have antitumor properties in vitro and in vivo. Yet, global response signatures to plasma treatment have not yet been identified. To this end, we screened eight human cancer cell lines to investigate effects of low-dose, tumor-static plasma-treated medium (PTM) on cellular activity, immune-modulatory properties, and transcriptional levels of 22 redox-related genes. With PTM, a moderate reduction of metabolic activity and modest modulation of chemokine/cytokine pattern and markers of immunogenic cell death was observed. Strikingly, the Nuclear factor (erythroid-derived 2)-like 2 (nrf2) target heme oxygenase 1 (hmox1) was upregulated in all cell lines 4 h post PTM-treatment. nrf2 was not changed, but its baseline expression inversely and significantly correlated with hmox1 expression after exposure to PTM. Besides awarding hmox1 a central role with plasma-derived oxidants, we present a transcriptional redox map of 22 targets and chemokine/cytokine secretion map of 13 targets across eight different human tumor cell lines of four tumor entities at baseline activity that are useful for future studies in this field. Full article
(This article belongs to the Special Issue Nrf2 in Dermatological Pathologies)
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Review

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17 pages, 3268 KiB  
Review
Redox for Repair: Cold Physical Plasmas and Nrf2 Signaling Promoting Wound Healing
Antioxidants 2018, 7(10), 146; https://doi.org/10.3390/antiox7100146 - 19 Oct 2018
Cited by 44 | Viewed by 5344
Abstract
Chronic wounds and ulcers are major public health threats. Being a substantial burden for patients and health care systems alike, better understanding of wound pathophysiology and new avenues in the therapy of chronic wounds are urgently needed. Cold physical plasmas are particularly effective [...] Read more.
Chronic wounds and ulcers are major public health threats. Being a substantial burden for patients and health care systems alike, better understanding of wound pathophysiology and new avenues in the therapy of chronic wounds are urgently needed. Cold physical plasmas are particularly effective in promoting wound closure, irrespective of its etiology. These partially ionized gases deliver a therapeutic cocktail of reactive oxygen and nitrogen species safely at body temperature and without genotoxic side effects. This field of plasma medicine reanimates the idea of redox repair in physiological healing. This review compiles previous findings of plasma effects in wound healing. It discusses new links between plasma treatment of cells and tissues, and the perception and intracellular translation of plasma-derived reactive species via redox signaling pathways. Specifically, (i) molecular switches governing redox-mediated tissue response; (ii) the activation of the nuclear E2-related factor (Nrf2) signaling, together with antioxidative and immunomodulatory responses; and (iii) the stabilization of the scaffolding function and actin network in dermal fibroblasts are emphasized in the light of wound healing. Full article
(This article belongs to the Special Issue Nrf2 in Dermatological Pathologies)
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7 pages, 389 KiB  
Review
Therapeutic Agents with AHR Inhibiting and NRF2 Activating Activity for Managing Chloracne
Antioxidants 2018, 7(7), 90; https://doi.org/10.3390/antiox7070090 - 13 Jul 2018
Cited by 22 | Viewed by 5379
Abstract
Chloracne is the major skin symptom caused by dioxin intoxication. Dioxin activates the aryl hydrocarbon receptor (AHR)–cytochrome p450 1A1 (CYP1A1) system, generates oxidative stress, and induces hyperkeratinization of keratinocytes and sebocytes leading to chloracne. Nuclear factor-erythroid 2-related factor-2 (NRF2) is a master switch [...] Read more.
Chloracne is the major skin symptom caused by dioxin intoxication. Dioxin activates the aryl hydrocarbon receptor (AHR)–cytochrome p450 1A1 (CYP1A1) system, generates oxidative stress, and induces hyperkeratinization of keratinocytes and sebocytes leading to chloracne. Nuclear factor-erythroid 2-related factor-2 (NRF2) is a master switch that induces the expression of various antioxidative enzymes, such as heme oxygenase-1. Cinnamaldehyde is an antioxidant phytochemical that inhibits AHR–CYP1A1 signaling and activates the NRF2–antioxidative axis. The cinnamaldehyde-containing Kampo herbal medicine Keishibukuryogan is capable of improving chloracne in Yusho patients who are highly contaminated with dioxin. Agents with dual functions in promoting AHR–CYP1A1 inhibition and NRF2 activation may be useful for managing dioxin-related health hazards. Full article
(This article belongs to the Special Issue Nrf2 in Dermatological Pathologies)
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