Dear Colleagues,

Chronic pain and its associated emotional disorders affect a high percentage of people and have a negative impact on their quality of life; as such, they are an important challenge in current pain research. Present therapies not only have multiple side effects, but more of them also fail to inhibit the anxiety, depression and/or memory loss associated with chronic pain. Thus, it is necessary to find safe and effective treatments for chronic pain and the accompanying emotional and/or cognitive deficiencies.

Oxidative stress and inflammation have been identified as two key factors of chronic pain development. Moreover, persistent inflammation can lead to the excessive production of free radicals, aggravating oxidative stress and vice versa. Oxidative stress can also activate redox-sensitive inflammatory mediators, causing uncontrolled inflammatory reactions. Then, although several treatments against chronic pain focus on decreasing the inflammation or the oxidative stress, most of them do not effectively alleviate pain symptoms and produce several side effects. In consequence, and considering that inflammation and oxidative stress are also involved in the development of emotive illnesses, more studies are required to clarify the molecular mechanisms implicated in these processes to permit finding new effective treatments for chronic pain and its linked mood disorders.

There is a wide variety of compounds whose analgesic properties and mechanisms of action have not yet been identified. This Special Issue on “New Treatments with Antioxidants for Chronic Pain and Mood Disorders Associated” aims to collect original research papers designed to identify new antioxidants capable of efficiently relieving chronic pain and its associated emotional disorders. We believe that this Special Issue will help advance the research on new effective strategies for the global treatment of chronic pain.

As the Guest Editor, I invite you to contribute to this Special Issue.

Dr. Olga Pol
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• analgesia
• antioxidants
• anxiety
• depression
• inflammation
• memory deficits
• oxidative stress
• pain