Special Issue "Antioxidants in Chronic Pain Volume 3"
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 7533
Interests: analgesia; anxiety; depression; cannabinoids; carbon monoxide; heme oxygenase 1; hydrogen sulfide; nitric oxide; Nrf2 transcription factor; oxidative stress; pain; opioids
Special Issues, Collections and Topics in MDPI journals
Special Issue in Antioxidants: Antioxidants in Chronic Pain II
Special Issue in Antioxidants: New Treatments with Antioxidants for Chronic Pain and Mood Disorders Associated
Chronic pain, defined as a syndrome characterized by persistent suffering for long periods of time, can originate and manifest in different forms, including diabetic neuropathy, osteoarthritic pain, inflammatory pain, or neuropathic pain, and affects a high percentage of people. When pain is prolonged for long periods of time, it is also accompanied by emotional disorders such as depression, anxiety, and cognitive deficits, which exert a negative impact on the perception of pain and can lead to significant deterioration in the patient’s quality of life. The optimum treatment of chronic pain is an unmet medical need and a major challenge in pain research, considering that current therapies have limited effectiveness and significant side effects.
Oxidative stress is highly implicated in the development of chronic pain and the associated emotional disorders. Reactive oxygen species (ROS) are elevated in the central and peripheral nervous system of animals with chronic pain, and ROS scavengers alleviate hyperalgesia. The role of several antioxidants in pain relief, by attenuating ROS generation and/or by activating the endogenous antioxidant system triggered by the nuclear factor erythroid-2 related factor 2 (Nrf2), heme oxygenase 1 (HO-1), NADPH quinone oxidoreductase 1, superoxide dismutase, glutathione peroxidase 1, and/or the catalase signaling pathway, has been demonstrated. Thus, Nrf2/HO-1 activators modulate the pronociceptive responses generated by nerve damage, inflammation, chemotherapeutic agents and/or hyperglycemia, and are regarded as a good therapeutic strategy.
There is a wide variety of antioxidant compounds with different structures and chemical properties whose analgesic properties and mechanisms of action during chronic pain have not been identified. This Special Issue on “Antioxidants in Chronic Pain Volume 3” aims to collect original research papers designed to identify new antioxidant compounds able to efficiently relieve chronic pain, such as potential therapeutic targets. We believe that this Special Issue will help to advance research on new effective strategies in the treatment of chronic pain.
We look forward to your contribution.
Dr. Olga Pol
Manuscript Submission Information
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- Heme oxygenase 1
- Nrf2 transcription factor
- oxidative stress