A Novel Therapy for Cisplatin-Induced Allodynia and Dysfunctional and Emotional Impairments in Male and Female Mice
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Experimental Design
2.3. Drug Administration
2.4. Allodynia
2.5. Forelimb Grip Strength Test
2.6. Anxiety and Depressive Conducts
2.7. Western Blot
2.8. Statistical Analyses
3. Results
3.1. The Prophylactic Treatment with HRW Inhibited the Mechanical and Cold Allodynia Generated by CIS in Male and Female Mice
3.2. The Effects of the Prophylactic Treatment with HRW on the Grip Strength Deficits and Body Weight Loss Produced by CIS in Male and Female Mice
3.3. Treatment with HRW Inhibited the Emotional Disorders Causes by CIS
3.4. Effects of HRW on the Inflammatory and Oxidative Reactions Provoked by CIS in the DRG and PFC
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Antibody | Dilution | Purchased |
---|---|---|
NLRP3 | 1:200 | Adipogen Life Sciences, Epalinges, Switzerland |
4-HNE | 1:200 | Abcam, Cambridge, UK |
HO-1 | 1:100 | Enzo Life Science, New York, NY, USA |
SOD-1 | 1:150 | Novus Biologic, Littleton, CO, USA |
GAPDH | 1:5000 | Merck, Billerica, MA, USA |
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Martínez-Martel, I.; Pol, O. A Novel Therapy for Cisplatin-Induced Allodynia and Dysfunctional and Emotional Impairments in Male and Female Mice. Antioxidants 2023, 12, 2063. https://doi.org/10.3390/antiox12122063
Martínez-Martel I, Pol O. A Novel Therapy for Cisplatin-Induced Allodynia and Dysfunctional and Emotional Impairments in Male and Female Mice. Antioxidants. 2023; 12(12):2063. https://doi.org/10.3390/antiox12122063
Chicago/Turabian StyleMartínez-Martel, Ignacio, and Olga Pol. 2023. "A Novel Therapy for Cisplatin-Induced Allodynia and Dysfunctional and Emotional Impairments in Male and Female Mice" Antioxidants 12, no. 12: 2063. https://doi.org/10.3390/antiox12122063