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Antioxidants
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The Role of Redox Modulation by Natural Agents under Steady...
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The Role of Redox Modulation by Natural Agents under Steady State or Inflammatory Conditions

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 4340

Special Issue Editors

Prof. Dr. Lilong Pan

E-Mail Website
Guest Editor
Department of Pharmacology, Jiangnan University, Wuxi 214122, China
Interests: anti-inflammatory immunopharmacology; pancreatitis; gut microbiota; intestinal inflammatory diseases
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Madhav Bhatia

E-Mail Website
Guest Editor
Department of Pathology and Biomedical Science, University of Otago, Christchurch, 2 Riccarton Avenue, P.O. Box 4345, Christchurch 8140, New Zealand
Interests: inflammation; acute pancreatitis; sepsis; burn injury; arthritis; hydrogen sulfide; substance P; chemokines; leukocytes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Reactive oxygen species (ROS) generated under physiological conditions are essential to maintain cell homeostasis. However, excessive ROS generation can result in oxidative stress and activate redox-sensitive signaling pathways, thereby provoking the onset and progression of various inflammation-related diseases, i.e., cardiovascular disease, diabetes, neurodegenerative diseases, etc.

Recent findings suggest the crucial role of natural agents, especially intestinal flora metabolites, endogenous active substances, and natural compounds with definite structure, in the regulation of various inflammation-related diseases by modulating oxidative stress. Meanwhile, recent evidence has highlighted specific natural agents as a potential therapeutic strategy for modulating oxidative stress and treating inflammation-related diseases. Meanwhile, despite extensive research efforts, the detailed mechanisms of natural agents on maintaining redox homeostasis or mediating inflammation-related diseases remain to be fully understood.

In this Special Issue of Antioxidants (MDPI), we welcome investigators to contribute original research articles reporting data from both experimental and clinical studies, as well as review articles that provide a better understanding of modulatory effects and underlying mechanisms of natural agents on oxidative stress-mediated inflammation and related disease development. It should be noted that for studies involving natural extracts, an accurate chemical and quantitative characterization (using analytical methodologies, such as HPLC, MS, LC–MS, HPLC–MS, and NMR) of active compounds in the extracts is required. In addition, basic and mechanistic research on redox modulation by natural agents under steady state is also welcome.

Dr. Lilong Pan
Prof. Dr. Madhav Bhatia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • redox homeostasis
  • cell homeostasis
  • physiological conditions
  • reactive oxygen species
  • ROS
  • oxidative stress
  • inflammation
  • diseases
  • cardiovascular disease
  • diabetes
  • neurodegenerative diseases
  • mechanisms of natural agents
  • natural compounds
  • intestinal flora metabolites
  • endogenous active substances
  • potential therapeutic strategy

Published Papers (2 papers)

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Research

10 pages, 2070 KiB  
Article
Maltol, a Natural Flavor Enhancer, Inhibits NLRP3 and Non-Canonical Inflammasome Activation
by Huijeong Ahn, Gilyoung Lee, Byung-Cheol Han, Seung-Ho Lee and Geun-Shik Lee
Antioxidants 2022, 11(10), 1923; https://doi.org/10.3390/antiox11101923 - 28 Sep 2022
Cited by 3 | Viewed by 1657
Abstract
Maltol (3-hydroxy-2-methyl-4-pyrone) is used widely as a food and cosmetic supplement, and it has antioxidant and anti-inflammatory activities. Inflammasome causes the maturation and secretion of interleukin (IL)-1β and -18 through the activation of caspase-1 (Casp1), which contributes to various inflammatory diseases. This study [...] Read more.
Maltol (3-hydroxy-2-methyl-4-pyrone) is used widely as a food and cosmetic supplement, and it has antioxidant and anti-inflammatory activities. Inflammasome causes the maturation and secretion of interleukin (IL)-1β and -18 through the activation of caspase-1 (Casp1), which contributes to various inflammatory diseases. This study examined the effects of maltol on the inflammasome activation in macrophages and mice. Lipopolysaccharide (LPS)-primed macrophages were treated with a trigger of NLRP3, NLRC4, AIM2, or non-canonical (NC) inflammasomes in the presence of maltol. The secretion of IL-1β and IL-18 and the cleavage of Casp1 were analyzed as indices of inflammasome activation. Mice were injected with LPS and an NLRP3 trigger with or without maltol, and the peritoneal IL-1β secretions were observed. The effects of maltol on reactive oxygen species (ROS) production and Casp1 activity were analyzed to determine the mechanism. Maltol inhibited the activation of NLRP3 and NC inflammasomes, but it did not alter the other inflammasomes. Maltol also attenuated IL-1β secretion resulting from the inflammasome activation in mice. The anti-inflammatory mechanism of maltol was revealed by the inhibition of ROS production and Casp1 activity. Maltol is suggested to be promising as a anti-inflammasome molecule. Full article
(This article belongs to the Special Issue The Role of Redox Modulation by Natural Agents under Steady State or Inflammatory Conditions)
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17 pages, 2674 KiB  
Article
Novel Probiotic Lactic Acid Bacteria Were Identified from Healthy Infant Feces and Exhibited Anti-Inflammatory Capacities
by Binbin Li, Li-Long Pan and Jia Sun
Antioxidants 2022, 11(7), 1246; https://doi.org/10.3390/antiox11071246 - 24 Jun 2022
Cited by 4 | Viewed by 2246
Abstract
The current study aims to evaluate the probiotic potential of lactic acid bacteria isolated from infant feces, and select candidates to be used as potential antioxidants for the treatment of oxidative stress-related diseases; To meet the criteria for probiotic attributes, the isolates were [...] Read more.
The current study aims to evaluate the probiotic potential of lactic acid bacteria isolated from infant feces, and select candidates to be used as potential antioxidants for the treatment of oxidative stress-related diseases; To meet the criteria for probiotic attributes, the isolates were subjected to various in vitro tests and 16S rRNA genotypic characterization. Besides, anti-inflammatory and anti-oxidative effects of selected isolates were separately assessed by real-time quantitative PCR and Western blot; The selected strains belonged to Lactobacillus gasseri, Lactiplantibacillus plantarum and Lacticaseibacillus rhamnosus. Notably, three selected strains (L. gasseri FWJL-4, L. plantarum Fjias-5 and L. rhamnosus FSJ-13) particularly L. gasseri FWJL-4 significantly down-regulated mRNA expression levels of tumor necrosis factor α (TNFα), Interleukin-6 (IL-6) and IL-1β. Most importantly, three strains-treated RAW 264.7 murine macrophages displayed enhanced activities of antioxidant enzymes and reduced H2O2 production, which were associated with the enhanced expression levels of nuclear factor-erythroid 2 related factor 2 and heme oxygenase-1; Three selected strains, particularly L. gasseri FWJL-4, are good candidates that merit additional in vivo investigation for the validation and application of their health-promoting effects. Full article
(This article belongs to the Special Issue The Role of Redox Modulation by Natural Agents under Steady State or Inflammatory Conditions)
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