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Antioxidants
Special Issues
Cell Therapy and Redox Regulation in Diseases: Potential and Implications
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Cell Therapy and Redox Regulation in Diseases: Potential and Implications

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 4196

Special Issue Editors

Dr. Claudia Fernanda Dick

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Guest Editor
Leopoldo de Meis Institute of Medical Biochemistry and National Center for Structural Biology and Bioimaging/CENABIO, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil
Interests: toxoplasma gondii; protozoan parasites; nutrient acquisition and metabolism; parasitic disease; oxidative stress in parasites; biochemistry of membrane transport
Prof. Dr. Adalberto Vieyra

E-Mail Website
Guest Editor
1. Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
2. National Center of Structural Biology and Bioimaging, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
Interests: kidney; acute and chronic kidney disease; vasoactive peptides; renal oxidative stress; cell therapy; extracellular vesicles; biophysics of membrane transport
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent decades, diseases that affect different tissues, organs, or systems have found new treatment approaches derived from so-called cell therapies. After many years in which bone-marrow transplants were the only cell therapies available for treating leukemias, the use of so-called “stem cells” began to spread throughout the world. Studies were initially restricted to basic experimentation (cellular and molecular) and pre-clinical assays using embryonic stem cells, mesenchymal cells (such as those from adipose tissue), bone-marrow mononuclear cells, and more recently, induced pluripotent cells. With the proliferation of successful clinical trials, a new field has emerged from the use of these cells—one that exploits the extracellular vesicles they secrete. Tissue redox alterations being one of the central features of highly prevalent acute and chronic diseases, the antioxidant potential of stem or related cells and the vesicles secreted by them has opened a new perspective: cell therapies that prevent, attenuate, or cure redox anomalies. The main objective of this Special Issue of Antioxidants is to capture a broad spectrum of original studies and reviews that involve, at the same time, experimental models or treatments with cellular or acellular therapies in infectious and non-infectious diseases, acute or chronic diseases (including degenerative), and targeting mechanisms of repair for redox alterations.

Dr. Claudia Fernanda Fernanda Dick
Dr. Adalberto Vieyra
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cell therapies
  • stem cells
  • mesenchymal cells
  • embryonic stem cells
  • induced pluripotent cells
  • extracellular vesicles
  • exosomes and microvesicles
  • anion superoxide
  • tissular oxidative stress
  • mitochondrial and extramitochondrial formation of oxygen reactive species
  • oxidative stress in infections
  • oxidative stress and cancer
  • antioxidant molecules

Published Papers (2 papers)

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Research

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14 pages, 3396 KiB  
Article
Nicotine and Cotinine Induce Neutrophil Extracellular Trap Formation—Potential Risk for Impaired Wound Healing in Smokers
by Romina H. Aspera-Werz, Jonas Mück, Caren Linnemann, Moritz Herbst, Christoph Ihle, Tina Histing, Andreas K. Nussler and Sabrina Ehnert
Antioxidants 2022, 11(12), 2424; https://doi.org/10.3390/antiox11122424 - 8 Dec 2022
Cited by 3 | Viewed by 1786
Abstract
Smoking undoubtedly affects human health. Investigating 2318 representative patients at a level 1 trauma center identified delayed wound healing, tissue infections, and/or sepsis as main complications in smokers following trauma and orthopedic surgery. Therefore, smoking cessation is strongly advised to improve the clinical [...] Read more.
Smoking undoubtedly affects human health. Investigating 2318 representative patients at a level 1 trauma center identified delayed wound healing, tissue infections, and/or sepsis as main complications in smokers following trauma and orthopedic surgery. Therefore, smoking cessation is strongly advised to improve the clinical outcome in these patients, although smoking cessation often fails despite nicotine replacement therapy raising the need for specific interventions that may reduce the complication rate. However, the underlying mechanisms are still unknown. In diabetics, delayed wound healing and infections/sepsis are associated with increased neutrophilic PADI4 expression and formation of neutrophil extracellular traps (NETs). The aim was to investigate if similar mechanisms hold for smokers. Indeed, our results show higher PADI4 expression in active and heavy smokers than non-smokers, which is associated with an increased complication rate. However, in vitro stimulation of neutrophils with cigarette smoke extract (CSE) only moderately induced NET formation despite accumulation of reactive oxygen species (ROS). Physiological levels of nicotine and its main metabolite cotinine more effectively induced NET formation, although they did not actively induce the formation of ROS, but interfered with the activity of enzymes involved in anti-oxidative defense and NET formation. In summary, we propose increased formation of NETs as possible triggers for delayed wound healing, tissue infections, and/or sepsis in smokers after a major trauma and orthopedic surgery. Smoking cessation might reduce this effect. However, our data show that smoking cessation supported by nicotine replacement therapy should be carefully considered as nicotine and its metabolite cotinine effectively induced NET formation in vitro, even without active formation of ROS. Full article
(This article belongs to the Special Issue Cell Therapy and Redox Regulation in Diseases: Potential and Implications)
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Review

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16 pages, 1388 KiB  
Review
Metabolic Functions of Biliverdin IXβ Reductase in Redox-Regulated Hematopoietic Cell Fate
by Wadie F. Bahou, Natalia Marchenko and Natasha M. Nesbitt
Antioxidants 2023, 12(5), 1058; https://doi.org/10.3390/antiox12051058 - 7 May 2023
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Abstract
Cytoprotective heme oxygenases derivatize heme to generate carbon monoxide, ferrous iron, and isomeric biliverdins, followed by rapid NAD(P)H-dependent biliverdin reduction to the antioxidant bilirubin. Recent studies have implicated biliverdin IXβ reductase (BLVRB) in a redox-regulated mechanism of hematopoietic lineage fate restricted to megakaryocyte [...] Read more.
Cytoprotective heme oxygenases derivatize heme to generate carbon monoxide, ferrous iron, and isomeric biliverdins, followed by rapid NAD(P)H-dependent biliverdin reduction to the antioxidant bilirubin. Recent studies have implicated biliverdin IXβ reductase (BLVRB) in a redox-regulated mechanism of hematopoietic lineage fate restricted to megakaryocyte and erythroid development, a function distinct and non-overlapping from the BLVRA (biliverdin IXα reductase) homologue. In this review, we focus on recent progress in BLVRB biochemistry and genetics, highlighting human, murine, and cell-based studies that position BLVRB-regulated redox function (or ROS accumulation) as a developmentally tuned trigger that governs megakaryocyte/erythroid lineage fate arising from hematopoietic stem cells. BLVRB crystallographic and thermodynamic studies have elucidated critical determinants of substrate utilization, redox coupling and cytoprotection, and have established that inhibitors and substrates bind within the single-Rossmann fold. These advances provide unique opportunities for the development of BLVRB-selective redox inhibitors as novel cellular targets that retain potential for therapeutic applicability in hematopoietic (and other) disorders. Full article
(This article belongs to the Special Issue Cell Therapy and Redox Regulation in Diseases: Potential and Implications)
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