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Antioxidants
Special Issues
Antioxidant and Biological Properties of Plant Extracts—3rd Edition
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Antioxidant and Biological Properties of Plant Extracts—3rd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: 15 May 2024 | Viewed by 5285

Special Issue Editors

Dr. Filomena Nazzaro

E-Mail Website
Guest Editor
Istituto di Scienze dell’Alimentazione, Consiglio Nazionale delle Ricerche (ISA-CNR), Via Roma 64, 83100 Avellino, Italy
Interests: antimicrobial activity of natural extracts/essential oils; microencapsulation of bacteria; entrappment of secondary metabolites; development of functional beverages; quorum sensing; biofilm; innovative technologies
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Vincenzo De Feo

E-Mail Website
Guest Editor
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy
Interests: herbs; essential oils; natural extracts; cytotoxicity; antimicrobial; biofilm
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Our previous Special Issues, the first and second volume “Antioxidant and Biological Properties of Plant Extracts” (https://www.mdpi.com/journal/antioxidants/special_issues/X0EES32U3F), received an overwhelming number of submissions and comprised a successful compilation of research and review articles. As this is a rapidly evolving topic, we would like to further explore the different actions of extracts or essential oils derived from herbs and spices, including ascertained antioxidant activity in the abovementioned critical situations, with a follow-up Special Issue in 2024.

Herbs and spices, with their well-known antioxidant activity, can prolong the shelf life of fresh and manufactured foods, preserving their quality and safety. For thousands of years, extracts and essential oils recovered from herbs and spices have also been used in folk medicine to limit pathology-associated cell damages linked to a dis-balance of reactive oxygen species (ROS) generation, which might allow the occurrence of inflammatory and dis-metabolic and cardiovascular diseases and, in some cases, concur with the onset of some cancer forms. They are used to fight against attacking and resistant pathogenic microorganisms, bacteria, fungi, and viruses, whose higher resistance to conventional drugs represents a severe problem for human health. Conversely, through their metabolites, they could be used as a support to stimulate the growth and the biological properties of beneficial bacteria (probiotics). In recent decades, the role of such antioxidants has also been investigated for their protective action in combating and curing ulcers in the gastrointestinal tract; hence, they may represent good therapeutic agents for developing new phyto-therapeutic medicines with antioxidant activity for treating such pathologies. Due to such a vast “portfolio” of beneficial effects, extracts and essential oils from herbs and spices are always interesting research fields. In addition, it must be taken into account that waste products can also represent a precious source of antioxidants.

Dr. Filomena Nazzaro
Prof. Dr. Vincenzo De Feo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant secondary metabolites
  • antioxidant effects
  • antimicrobial effects
  • anti-inflammatory effects cytotoxic effects
  • antiproliferative effect
  • gastrointestinal tract
  • food safety
  • neuroprotective effects
  • pre-biotics
  • post-biotics

Published Papers (4 papers)

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Research

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13 pages, 1135 KiB  
Article
Ultra-High-Resolution Liquid Chromatography Coupled with Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometry Analysis of Tessaria absinthioides (Hook. & Arn.) DC. (Asteraceae) and Antioxidant and Hypocholesterolemic Properties
by Mariana Rey, María Sol Kruse, Jessica Gómez, Mario J. Simirgiotis, Alejandro Tapia and Héctor Coirini
Antioxidants 2024, 13(1), 50; https://doi.org/10.3390/antiox13010050 - 28 Dec 2023
Viewed by 913
Abstract
Recently, we reported the chemical profile and the hypocholesterolemic effects of a decoction of Tessaria absinthioides (Hook. & Arn.) DC. (Asteraceae). In this study, we evaluated a methanolic extract (METa) instead. Metabolite profiling was conducted using ultra-high-resolution liquid chromatography coupled with electrospray ionization [...] Read more.
Recently, we reported the chemical profile and the hypocholesterolemic effects of a decoction of Tessaria absinthioides (Hook. & Arn.) DC. (Asteraceae). In this study, we evaluated a methanolic extract (METa) instead. Metabolite profiling was conducted using ultra-high-resolution liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (UHPLC-ESI-QTOF-MS), identifying thirty compounds, including flavonoids, phenolic acids, fatty acids, and phorbolesters. Antioxidant properties were assessed through 2,2-diphenyl-1-picrylhydrazyl (DPPH), Trolox equivalent antioxidant activity (TEAC), ferric-reducing antioxidant power (FRAP), and inhibition of lipid peroxidation in erythrocytes (ILP) assays, exhibiting robust antioxidant activity. The in vivo impact of METa on serum lipid parameters and liver X receptors (LXRs) was evaluated in a hypercholesterolemic animal model. After 14 days on a high-fat diet, male rats received either a vehicle (V) or METa100, METa200 or METa500 (100; 200 and 500 mg METa/kg animal, respectively) for an additional two weeks. METa500 reduced total cholesterol levels (17.62%; p < 0.05) and all doses increased high-density lipoprotein cholesterol levels (METa100: 86.27%; METa200: 48.37%, and METa500: 29.42%; p < 0.0001). However, METa did not alter LXRs expression. The observed antioxidant and hypocholesterolemic properties of METa may be linked to the presence of six di-caffeoylquinic acids. These findings underscore T. absinthioides as a potential candidate for the treatment of metabolic disease. Full article
(This article belongs to the Special Issue Antioxidant and Biological Properties of Plant Extracts—3rd Edition)
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20 pages, 1423 KiB  
Article
Antioxidant Properties and Geroprotective Potential of Wheat Bran Extracts with Increased Content of Anthocyanins
by Daria V. Mikhailova, Oksana G. Shevchenko, Denis A. Golubev, Elena Y. Platonova, Nadezhda V. Zemskaya, Olesya Yu. Shoeva, Elena I. Gordeeva, Sergey A. Patov, Mikhail V. Shaposhnikov, Elena K. Khlestkina and Alexey Moskalev
Antioxidants 2023, 12(11), 2010; https://doi.org/10.3390/antiox12112010 - 17 Nov 2023
Viewed by 1079
Abstract
In recent years, there has been a focus on breeding wheat with high anthocyanin levels in order to improve food quality and human health. The objective of this study was to examine the antioxidant and geroprotective properties of wheat bran extracts using both [...] Read more.
In recent years, there has been a focus on breeding wheat with high anthocyanin levels in order to improve food quality and human health. The objective of this study was to examine the antioxidant and geroprotective properties of wheat bran extracts using both in vitro and in vivo research methods. Two wheat lines were used: one with uncolored pericarp (anthocyanin-free) and another with colored pericarp (anthocyanin-containing). These lines differed in a specific region of chromosome 2A containing the Pp3/TaMyc1 gene, which regulates anthocyanin production. High-performance liquid chromatography-mass spectrometry revealed the presence of cyanidin glucoside and cyanidin arabinoside in the anthocyanin-containing wheat bran extract (+AWBE), while no anthocyanins were found in the anthocyanin-free wheat bran extract (−AWBE). The +AWBE showed higher radical scavenging activity (DPPH and ABTS assays) and membrane protective activity (AAPH oxidative hemolysis model) compared to the −AWBE. Both extracts extended the lifespan of female Drosophila, indicating geroprotective properties. This study demonstrates that wheat bran extracts with high anthocyanin levels have antioxidant and geroprotective effects. However, other secondary metabolites in wheat bran can also contribute to its antioxidant and geroprotective potential. Full article
(This article belongs to the Special Issue Antioxidant and Biological Properties of Plant Extracts—3rd Edition)
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15 pages, 2668 KiB  
Article
Demethylcalabaxanthone from Garcinia mangostana Exerts Antioxidant Effects through the Activation of the Nrf2 Pathway as Assessed via Molecular Docking and Biological Evaluation
by Simona De Vita, Milena Masullo, Sabrina Grambone, Paloma Bermejo Bescós, Sonia Piacente and Giuseppe Bifulco
Antioxidants 2023, 12(11), 1980; https://doi.org/10.3390/antiox12111980 - 07 Nov 2023
Viewed by 991
Abstract
Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway activation promotes the expression of antioxidant enzymes in response to rising oxidative stress, resulting in reactive oxygen species (ROS) detoxification and playing a central role in the maintenance of intracellular redox homeostasis and regulation of [...] Read more.
Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway activation promotes the expression of antioxidant enzymes in response to rising oxidative stress, resulting in reactive oxygen species (ROS) detoxification and playing a central role in the maintenance of intracellular redox homeostasis and regulation of inflammation. Moreover, the biological effects of Nrf2 pathway activation contribute to reducing apoptosis and enhancing cell survival. The activity of Nrf2 is negatively regulated by Kelch-like ECH-associated protein 1 (Keap1). Prompted by the recent results reporting the impact of xanthone metabolites on oxidative stress, cancer, and inflammation, the antioxidant properties of xanthones isolated from Garcinia mangostana (γ-mangostin, α-mangostin, 8-deoxygartanin, demethylcalabaxanthone, garcinone D) were assessed. In particular, the capability of these natural products to disrupt the interaction between Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor erythroid 2-related factor 2 (Nrf2), triggering the activation of the Nrf2-mediated pathway, was evaluated using molecular docking experiments and in vitro tests. The modulation of some key Nrf2-related mediators like glutathione (GSH) and lactate dehydrogenase (LDH) to highlight a possible direct antioxidant effect was investigated. Among the tested compounds, demethylcalabaxanthone showed an indirect antioxidant effect, as corroborated by a Western blot assay, displaying a significant increase in the translocated protein upon its administration. Full article
(This article belongs to the Special Issue Antioxidant and Biological Properties of Plant Extracts—3rd Edition)
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Review

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40 pages, 7715 KiB  
Review
Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis
by Luiz José Valotto Neto, Matheus Reverete de Araujo, Renato Cesar Moretti Junior, Nathalia Mendes Machado, Rakesh Kumar Joshi, Daiene dos Santos Buglio, Caroline Barbalho Lamas, Rosa Direito, Lucas Fornari Laurindo, Masaru Tanaka and Sandra Maria Barbalho
Antioxidants 2024, 13(4), 393; https://doi.org/10.3390/antiox13040393 - 25 Mar 2024
Viewed by 1665
Abstract
The aging of the global population has increased the prevalence of neurodegenerative conditions. Bacopa monnieri (BM), an herb with active compounds, such as bacosides A and B, betulinic acid, loliolide, asiatic acid, and quercetin, demonstrates the potential for brain health. Limited research has [...] Read more.
The aging of the global population has increased the prevalence of neurodegenerative conditions. Bacopa monnieri (BM), an herb with active compounds, such as bacosides A and B, betulinic acid, loliolide, asiatic acid, and quercetin, demonstrates the potential for brain health. Limited research has been conducted on the therapeutic applications of BM in neurodegenerative conditions. This systematic review aims to project BM’s beneficial role in brain disorders. BM has anti-apoptotic and antioxidant actions and can repair damaged neurons, stimulate kinase activity, restore synaptic function, improve nerve transmission, and increase neuroprotection. The included twenty-two clinical trials demonstrated that BM can reduce Nuclear Factor-κB phosphorylation, improve emotional function, cognitive functions, anhedonia, hyperactivity, sleep routine, depression, attention deficit, learning problems, memory retention, impulsivity, and psychiatric problems. Moreover, BM can reduce the levels of pro-inflammatory biomarkers and oxidative stress. Here, we highlight that BM provides notable therapeutic benefits and can serve as a complementary approach for the care of patients with neurodegenerative conditions associated with brain disorders. This review adds to the growing interest in natural products and their potential therapeutic applications by improving our understanding of the mechanisms underlying cognitive function and neurodegeneration and informing the development of new therapeutic strategies for neurodegenerative diseases. Full article
(This article belongs to the Special Issue Antioxidant and Biological Properties of Plant Extracts—3rd Edition)
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