Mineral Element, Antioxidant Responses and Metabolism in Vertebrates

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 2847

Special Issue Editors

Laboratory of Molecular Nutrition for Aquatic Economic Animals, Fishery College, Huazhong Agricultural University, Wuhan 430070, China
Interests: molecular nutrition; metabolic regulation; oxidative stress; molecular toxicology; aquatic economic animals
Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China
Interests: Aquculture, Nutrition, Immunology, Flesh quality, Intestinal health
College of Animal Nutrition and Feed Science, Huazhong Agricultural University, Wuhan 430070, China
Interests: animal nutrition; feed safety; mycotoxins; animal health; selenium
Special Issues, Collections and Topics in MDPI journals
King’s College London, Department of Nutritional Sciences, School of Life Course Sciences, London SE1 9NH, UK
Interests: zinc; metallomics; irritable bowel disease; diabetes; molecular toxicology

Special Issue Information

Dear Colleagues,

Mineral elements, such as calcium, copper, zinc, iron, magnesium, manganese, selenium, and phosphorus, play important roles in numerous physiological and biochemical processes in all vertebrates. Their inclusions in diets are necessary, considering that most animals derive these minerals mainly from diets. However, excess intake of minerals can be toxic to animals and adversely influence growth performance, antioxidant responses, and metabolism. Thus, a thorough understanding of mineral nutrition in vertebrates is of fundamental importance.

Recently, many important advances have been made, which are involved in the uptake, transport, and homeostatic regulation of mineral elements in animals, and other studies have revealed the effects and mechanisms of mineral elements influencing antioxidant responses and metabolism. In particular, many mineral-element-induced metabolic dysfunctions are closely related to the dysregulation of antioxidant responses and the occurrence of oxidative stress. Therefore, the investigation into the underlying mechanism of mineral-element-induced changes of antioxidant responses and metabolism, and their interaction will deepen our understanding into mineral nutrition, which preserves health or prevents the occurrence of disease.

In this Special Issue, we aim to collate papers dealing with the interaction of mineral elements with antioxidant responses and metabolism across vertebrates, including humans and terrestrial and aquatic species. The focus will be on studies that elucidate underlying molecular mechanisms of such interactions, and descriptive studies will not be accepted.

Prof. Dr. Zhi Luo
Prof. Dr. Lin Feng
Prof. Dr. Lvhui Sun
Prof. Dr. Christer Hogstrand
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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18 pages, 3926 KiB  
Hydroxy Selenomethionine Improves Meat Quality through Optimal Skeletal Metabolism and Functions of Selenoproteins of Pigs under Chronic Heat Stress
Antioxidants 2021, 10(10), 1558; https://doi.org/10.3390/antiox10101558 - 29 Sep 2021
Cited by 15 | Viewed by 2274
Chronic heat stress (CHS) induces metabolic changes in skeletal muscle from growth to maintenance that jeopardizes growth performance, carcass traits, and meat quality of pigs. We investigated the protective effect of dietary organic selenium (hydroxy-4-methylselenobutanoic acid, OH-SeMet) on CHS-induced skeletal muscle damages of [...] Read more.
Chronic heat stress (CHS) induces metabolic changes in skeletal muscle from growth to maintenance that jeopardizes growth performance, carcass traits, and meat quality of pigs. We investigated the protective effect of dietary organic selenium (hydroxy-4-methylselenobutanoic acid, OH-SeMet) on CHS-induced skeletal muscle damages of growing pigs, and the corresponding responses of selenoproteins. A total of 40 ((Landrace ×Yorkshire) × Duroc) pigs with an average live weight of 49.64 ± 2.48 kg were used in this 4-week trial. Pigs were randomly allotted to 5 groups: The control group was raised on a basal diet in a thermoneutral environment (22 ± 2 °C); and four CHS groups were raised on a basal diet and supplemented with Se 0.0, 0.2, 0.4, and 0.6 mg/kg as OH-SeMet, respectively, in hyperthermal condition (33 ± 2 °C). CHS resulted in significant decrease of growth performance, carcass traits, and meat quality, which were associated with reduced (p < 0.05) serum alkaline phosphatase (ALP) and total superoxide dismutase (T-SOD) and increased (p < 0.05) serum creatine (CK), sarcous heat shock protein 70 (HSP70), glucokinase (GCK), phosphoenolpyruvate carboxykinase (PEPCK), and malondialdehyde (MDA) contents. Meanwhile, four metabolism-related genes and seven selenoprotein encoding genes were abnormally expressed in skeletal muscle. Dietary OH-SeMet addition partially alleviated the negative impact of CHS on carcass traits and improved meat quality. These improvements were accompanied by the increase in Se deposition, the anti-oxidative capacity of serum and muscle, and protein abundance of GPX1, GPX3, GPX4, and SELENOP. Supplementation with 0.6 mg Se/kg (OH-SeMet) restored the sarcous PEPCK, and 0.4 and 0.6 mg Se/kg (OH-SeMet) restored all abnormally expressed metabolism-related and selenoprotein encoding genes. In summary, dietary supplementation with OH-SeMet beyond Se requirement mitigated CHS-induced depression of carcass traits and meat quality of pigs associated with optimal skeletal metabolism, enhanced antioxidant capacity, and regulation of selenoproteins in skeletal muscle of pigs. Full article
(This article belongs to the Special Issue Mineral Element, Antioxidant Responses and Metabolism in Vertebrates)
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