Application of Analytical Technology in Metabolomics

Topic Information

Dear Colleagues,

Metabolomics, as an important part of systems biology, is concerned with both targeted and untargeted analysis of endogenous and exogenous small molecule metabolites found within a biological sample. Metabolomics is a powerful approach for biomarker discovery with the technological advancement in the Analytical and identification of small molecules for early diagnosis, monitoring therapeutic response, and establishing disease pathogenesis. These cutting-edge technologies, which include accurate measurement of HPLC/UPLC, CE, HRMS, and NMR technology, can perform the detection of metabolites within minutes. The metabolomics field is gaining popularity due to the development of new Analytical methods and innovative sample processing techniques. In the light of the impressive past and ongoing development in the area of metabolomics by the use of modern analytical methods in conjunction with Analytical techniques, we believe that this Topic will bring together original research papers as well as review articles that highlight recent advances in innovative sample processing, current Analytical, and targeted & untargeted methods for bioanalysis/preclinical and clinical analysis in the field of metabolomics. Additionally, miniaturization of sample processing methods for metabolomics analysis is also welcome.

Dr. Preeti Chandra
Dr. Ugo Bussy
Dr. Raúl G. Enríquez
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Analytica analytica	-	-	2020	14.5 Days	CHF 1000	Submit
Metabolites metabolites	4.1	5.3	2011	12.9 Days	CHF 2700	Submit
Toxins toxins	4.2	7.5	2009	14.9 Days	CHF 2700	Submit
Molecules molecules	4.6	6.7	1996	13.6 Days	CHF 2700	Submit
Cells cells	6.0	9.0	2012	18.8 Days	CHF 2700	Submit

Published Papers (2 papers)

Order results

Content type Publication Date

Result details

Normal Extended Compact

Journals

All Analytica Metabolites Toxins Molecules Cells

Show export options expand_more Show export options expand_less

Select all

Export citation of selected articles as:

Plain Text BibTeX BibTeX (without abstracts) Endnote Endnote (without abstracts) Tab-delimited RIS

Error

Oops... you haven't selected anything for export.

Ok

clear

attachment

Supplementary material:
Supplementary File 1 (ZIP, 108 KiB)

11 pages, 1990 KiB  

Open AccessArticle

Identification of Sanguinarine Metabolites in Rats Using UPLC-Q-TOF-MS/MS

by

Mengting Liu

,

Zhiqin Liu

,

Zhuang Dong

,

Xianglin Zou

,

Jianguo Zeng

and

Zihui Yang

Molecules 2023, 28(22), 7641; https://doi.org/10.3390/molecules28227641 - 17 Nov 2023

Viewed by 307

Abstract

Sanguinarine (SAN), as the main active component of a traditional Chinese veterinary medicine, has been widely used in the animal husbandry and breeding industry. However, the metabolites of SA are still uncertain. Therefore, this research aimed to investigate the metabolites of SA based [...] Read more.

Sanguinarine (SAN), as the main active component of a traditional Chinese veterinary medicine, has been widely used in the animal husbandry and breeding industry. However, the metabolites of SA are still uncertain. Therefore, this research aimed to investigate the metabolites of SA based on rats in vivo. The blood, feces, and urine of rats were collected after the oral administration of 40 mg/kg SAN. Ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS) was employed to identify the metabolites of SAN. The elemental composition of sanguinarine metabolites was inferred by analyzing their exact molecular weight, and the structures of the metabolites were predicted based on their fragment ions and cleavage pathways. A total of 12 metabolites were identified, including three metabolites in the plasma, four in the urine, and nine in the feces. According to the possible metabolic pathways deduced in this study, SAN was mainly metabolized through reduction, oxidation, demethylation, hydroxylation, and glucuronidation. This present research has summarized the metabolism of SAN in rats, which is helpful for further studying the metabolic mechanism of SAN in vivo and in vitro. Full article

(This article belongs to the Topic Application of Analytical Technology in Metabolomics)

►▼ Show Figures

Graphical abstract

attachment

Supplementary material:
Supplementary File 1 (ZIP, 1492 KiB)

10 pages, 1843 KiB  

Open AccessArticle

The Synthesis of Biphasic Metabolites of Carfentanil

by

Junchang Wang

,

Jianwen Hu

,

Pingyong Liao

,

Shang Xue

,

Shan He

,

Ruijia Chen

,

Xuejun Zhao

and

Wenbin Liu

Molecules 2023, 28(22), 7625; https://doi.org/10.3390/molecules28227625 - 16 Nov 2023

Viewed by 348

Abstract

Carfentanil is an ultra-potent synthetic opioid. The Russian police force used both carfentanil and remifentanil to resolve a hostage incident in Moscow. This reported use sparked an interest in the pharmacology and toxicology of carfentanil in the human body, and data on its [...] Read more.

Carfentanil is an ultra-potent synthetic opioid. The Russian police force used both carfentanil and remifentanil to resolve a hostage incident in Moscow. This reported use sparked an interest in the pharmacology and toxicology of carfentanil in the human body, and data on its metabolites were later published. However, there have been few studies on the synthesis of carfentanil metabolites, and biological extraction has also put forward large uncertainty in subsequent studies. The aim of the present study is to investigate the synthesis of biphasic metabolites that are unique to carfentanil. The purpose was to produce corresponding metabolites conveniently, quickly, and at low cost that can be used for comparison with published structures and to confirm the administration of carfentanil. Full article

(This article belongs to the Topic Application of Analytical Technology in Metabolomics)

►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less

Select all

Export citation of selected articles as:

Plain Text BibTeX BibTeX (without abstracts) Endnote Endnote (without abstracts) Tab-delimited RIS

 

Error

Oops... you haven't selected anything for export.

Ok

clear

Displaying articles 1-2