Applications of the Zebrafish Model
Zebrafish has become an increasingly important model organsim for studying a wide variety of biological processes. Since being identified as a genetic model animal in the 1980s, it has been used for deciphering developmental mechanisms with great success. Importantly, more than 70% of human genes have at least one zebrafish orthologue, and 84% of human disease genes have an equivalent in zebrafish. Therefore, the application of zebrafish model in biomedical researches has rapidly expanded over the past two decades. This Topic welcomes submissions of original research and review manuscripts focusing on the application of zebrafish model for understanding molecular and cellular mechanisms underlying physiological and pathological processes. It covers large aspects of studies by taking advantage of the zebrafish model, including but not limited to early development, morphogenesis, organogenesis, tissue regeneration, neural function, reproduction, behaviors, disease modeling, drug screening, toxicology, live Imaging, multiomics and gene mutations by genome-editing approach. The aim is to provide an overview of the strong potential in applying the zebrafish model for understanding development and disease.
Dr. De-Li Shi
Dr. Pengfei Xu
- disease modeling
- gene mutation and function
- drug screening
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