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Viruses
Special Issues
Newcastle Disease and Other Avian Orthoavulaviruses 1
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Newcastle Disease and Other Avian Orthoavulaviruses 1

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: 15 August 2024 | Viewed by 570

Special Issue Editors

Dr. Chang-Won Lee

E-Mail Website
Guest Editor
Southeast Poultry Research Laboratory, US National Poultry Research Center, Agricultural Research Service, US Department of Agriculture, Athens, GA, USA
Interests: newcastle disease; avian influenza; pathogenesis; vaccine
Dr. Abhijeet Bakre

E-Mail Website
Guest Editor
Southeast Poultry Research Laboratory, US National Poultry Research Center, Agricultural Research Service, US Department of Agriculture, Athens, GA, USA
Interests: newcastle disease; avian influenza; host-virus interactions; non-coding RNAs; next generation sequencing; point of care assays

Special Issue Information

Dear Colleagues,

Newcastle disease (ND) is one of the most important poultry diseases worldwide that is caused by virulent avian orthoavulavirus 1 (AOAV-1), which is commonly known as avian paramyxovirus 1 (APMV-1) or Newcastle disease virus (NDV). In spite of the routine immunization with live and killed vaccines that is incorporated into vaccination programs, ND and low-virulence AOAV-1-related problems remain a considerable cause of economic loss to the poultry industry. Although AOAV-1 primarily affects birds, the virus can infect non-avian hosts including humans, where fatal cases have been reported. The control of Newcastle disease and other AOAV-1 infections requires multifaceted approaches with a better understanding of the causative agents, epidemiology, pathogenesis, and immunity.

For this Special Issue entitled “Newcastle Disease and Other Avian Orthoavulaviruses 1”, we invite the submission of original research articles and reviews focusing on both fundamental and applied aspects of AOAV-1 research.

Dr. Chang-Won Lee
Dr. Abhijeet Bakre
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Newcastle disease
  • avian orthoavulaviruses 1
  • epidemiology
  • pathogenesis
  • immunity
 

Published Papers (1 paper)

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Research

16 pages, 2816 KiB  
Article
The W195 Residue of the Newcastle Disease Virus V Protein Is Critical for Multiple Aspects of Viral Self-Regulation through Interactions between V and Nucleoproteins
by Qiaolin Wei, Wenbin Wang, Fanxing Meng, Ying Wang, Ning Wei, Jianxia Tian, Hanlue Li, Qiqi Hao, Zijie Zhou, Haijin Liu, Zengqi Yang and Sa Xiao
Viruses 2024, 16(4), 584; https://doi.org/10.3390/v16040584 - 10 Apr 2024
Viewed by 383
Abstract
The transcription and replication of the Newcastle disease virus (NDV) strictly rely on the viral ribonucleoprotein (RNP) complex, which is composed of viral NP, P, L and RNA. However, it is not known whether other viral non-RNP proteins participate in this process for [...] Read more.
The transcription and replication of the Newcastle disease virus (NDV) strictly rely on the viral ribonucleoprotein (RNP) complex, which is composed of viral NP, P, L and RNA. However, it is not known whether other viral non-RNP proteins participate in this process for viral self-regulation. In this study, we used a minigenome (MG) system to identify the regulatory role of the viral non-RNP proteins V, M, W, F and HN. Among them, V significantly reduced MG-encoded reporter activity compared with the other proteins and inhibited the synthesis of viral mRNA and cRNA. Further, V interacted with NP. A mutation in residue W195 of V diminished V–NP interaction and inhibited inclusion body (IB) formation in NP-P-L-cotransfected cells. Furthermore, a reverse-genetics system for the highly virulent strain F48E9 was established. The mutant rF48E9-VW195R increased viral replication and apparently enhanced IB formation. In vivo experiments demonstrated that rF48E9-VW195R decreased virulence and retarded time of death. Overall, the results indicate that the V–NP interaction of the W195 mutant V decreased, which regulated viral RNA synthesis, IB formation, viral replication and pathogenicity. This study provides insight into the self-regulation of non-RNP proteins in paramyxoviruses. Full article
(This article belongs to the Special Issue Newcastle Disease and Other Avian Orthoavulaviruses 1)
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