Progress and Prospects in Oncolytic Virotherapy
Deadline for manuscript submissions: 30 September 2024 | Viewed by 273
Interests: virus–host interactions; viral vectors; oncovirotherapy; antiviral strategies
Oncovirotherapy is a very promising strategy to tackle tumors based on viruses that either naturally or upon specific manipulations display direct cancer-cell-killing activity along with immunotherapeutic effects. Although a growing number of clinical studies clearly demonstrate the excellent safety profile of oncolytic viruses, to date, only the HSV-1 talimogene laherparepvec (T-Vec) has been approved in the USA and Europe for the treatment of unresectable melanoma. One of the reasons for the limited approval of oncolytic viruses can be found in their adoption as monotherapy in most of the clinical trials performed so far, often resulting in poor efficacy. This Special Issue aims to present readers with the latest developments and challenges in the field of oncolytic virus research. Additionally, we aim to evaluate the therapeutic possibilities of integrating oncovirotherapy with chemotherapy or immunotherapy.
Dr. Arianna Calistri
Dr. Sandra Tuyaerts
Manuscript Submission Information
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- preclinical studies
- clinical trials
- combinatory strategy
- safety profile
- therapeutic efficacy