Within-Host Viral Dynamics: A Window into Viral Evolution
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "General Virology".
Deadline for manuscript submissions: 31 May 2024 | Viewed by 1515
Special Issue Editors
Interests: viral metagenomics; human genomics; bioinformatics; hepatitis viruses
Interests: hepatitis B virus; blood virome; emerging infectious diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Evolution is the cornerstone in modern biomedicine. However, studying evolution is a challenge in higher organisms owing to their sizable genomes and low mutation rates. Measurable alterations related to evolution can take up to millions of years to develop. Given their tiny genomes, short replication cycles, and high mutation rates, viruses represent an attractive model for studying evolution in vivo. While the entire course of viral infection in hosts can be viewed as an evolutionary episode, our knowledge on underlying mechanisms that drive viral evolution is far from complete. How is the evolutionary process shaped by viral interaction with host innate and adaptive immunity? What is the contribution of the viral intrinsic mutation rate and replication strategy? Does the human microbiome influence viral evolution, and if so, how? Within-host viral dynamics provide an excellent opportunity to study these complex interactions and their roles in infection outcomes. The advent of deep sequencing techniques and other omics approaches now allow an unbiased investigation of the entire viral population in the context of micro- and macroenvironments. These articles will give us deep insights into viral evolution that are relevant to the prevention, diagnosis, and treatment of viral diseases.
Dr. Xiaofeng Fan
Dr. Mahmoud Reza Pourkarim
Guest Editors
Manuscript Submission Information
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Keywords
- virome
- metagenomics
- phylogenetics
- viral evolution
- quasispecies
- infectious diseases
