Bladder Exstrophy-Epispadias Complex (BEEC): Current Management and Evolving Paradigms

A special issue of Uro (ISSN 2673-4397).

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 4263

Special Issue Editors


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Guest Editor
Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India
Interests: congenital anomalies of the kidney and urinary tract (CAKUT); portal hypertension; craniosynostosis; minimally invasive pediatric surgery; reconstructive pediatric surgery

E-Mail Website
Guest Editor
Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India
Interests: congenital anomalies of the kidney and urinary tract (CAKUT); pediatric urology; pediatric robotic surgery; pediatric laparoscopic surgery; video-assisted thoracoscopic surgery

Special Issue Information

Dear Colleagues,

The surgical management of bladder exstrophy has evolved immensely over the years. The goals of reconstructive procedures in bladder exstrophy are to achieve satisfactory continence, normal upper tract preservation, and the creation of cosmetically acceptable external genitalia. Various studies have explored these outcomes in patients following exstrophy repair. However, there are many areas where consensus is lacking, e.g., in the role of osteotomy during exstrophy surgery, upper tract function following BEEC repair, the optimal timing of BEEC repair, the choice of conduit for augmentation, the risk of malignancy following BEEC repair, etc. This Special Issue plans to highlight the abovementioned areas and is also aimed at providing selected contributions on the evolving paradigms and recent advances in the surgical management of these cases.

Potential topics include, but are not limited to:

  • The evolution of different surgical approaches;
  • Long-term outcomes following BEEC repair in terms of bladder capacity;
  • Upper tract function after BEEC repair;
  • The role of osteotomy in bladder exstrophy surgery;
  • Bladder augmentation and its outcomes in children with bladder exstrophy;
  • Risk of malignancy in children with BEEC:
  • The role of histology and surveillance;
  • Neobladder creation in BEEC;
  • Bladder neck repair;
  • Epispadias repair and penile lengthening;
  • Sexual function in BEEC patients.

Prof. Dr. Minu Bajpai
Dr. Sachit Anand
Guest Editors

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Published Papers (2 papers)

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7 pages, 4765 KiB  
Article
Single-Stage Trans-Vestibular and Foley’s-Assisted Epispadias Repair (STAFER) for Girls with Incontinent Epispadias: A Retrospective Study from a Tertiary-Care Center
by Minu Bajpai, Sachit Anand and Prabudh Goel
Uro 2022, 2(2), 93-99; https://doi.org/10.3390/uro2020011 - 20 Apr 2022
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Abstract
Objective: The aim of this study was to evaluate the outcomes of single-stage trans-vestibular and Foley’s assisted epispadias repair (STAFER) technique in girls with incontinent epispadias. Methods: The records of all girls who had undergone epispadias repair and bladder neck plication via the [...] Read more.
Objective: The aim of this study was to evaluate the outcomes of single-stage trans-vestibular and Foley’s assisted epispadias repair (STAFER) technique in girls with incontinent epispadias. Methods: The records of all girls who had undergone epispadias repair and bladder neck plication via the STAFER technique over a four-year study period (January 2016 to December 2019) were retrospectively reviewed from the archives. A comparison of preoperative and postoperative functional outcomes was performed. Incontinence status was divided into four grades on the basis of severity: grade 0 (completely dry during day and night), grade 1 (occasional episodes of urine leakage leading to damp undergarments or requiring pads occasionally but not daily), grade 2 (frequent episodes of urine leakage with a dry period of <3 h), and grade 3 (completely incontinent). Renal bladder ultrasound (RBUS), micturating cystourethrogram (MCUG) scan, technetium-99m diethylenetriamine pentaacetate (DTPA) scan, and technetium-99m dimercaptosuccinic acid (DMSA) scan were performed to assess the upper tract function. Results: Nine girls with average (SD) age at surgery of 7.9 (3.8) years were operated on utilizing the STAFER technique during the study period. All cases had grade 3 incontinence and normal upper tracts prior to the surgery. Postoperatively, 8/9 girls had a dry period of more than 3 h. Six of them were completely dry and had no wetting episodes (grade 0 incontinence). DMSA and DTPA scans showed preserved upper tracts while MCUG scans revealed grade II VUR in only one case. Conclusions: In a limited cohort of girls with incontinent epispadias, the STAFER technique provides favorable functional outcomes in terms of continence and upper tract function. Further studies comprising a larger cohort of patients with a younger average age at surgery need to be conducted before definite conclusions regarding the efficacy of this technique are drawn. Full article
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6 pages, 223 KiB  
Protocol
Analysis of Multi-Cavity (Bladder, Intestinal and Vaginal) Microbiome in Bladder Cancer Patients: Protocol for a Systematic Review
by Marie Semmler, Uwe Bieri, Andres Affentranger, Dominik Enderlin, Luca Truscello, Thomas Scherer, Silvan Sigg, Ernest Kaufmann, Michael Scharl, Daniel Eberli and Cédric Poyet
Uro 2022, 2(3), 151-156; https://doi.org/10.3390/uro2030018 - 01 Jul 2022
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Abstract
The overall pathogenesis of bladder cancer is still unknown. The microbiota has been shown to play a critical role in the development of different types of cancer. Nevertheless, the role of the microbiota in the development of bladder cancer is still not fully [...] Read more.
The overall pathogenesis of bladder cancer is still unknown. The microbiota has been shown to play a critical role in the development of different types of cancer. Nevertheless, the role of the microbiota in the development of bladder cancer is still not fully discovered. This review aims to assess the urinary, vaginal, and intestinal microbiota analyzed from the bacterial, viral, and fungal compartments of bladder cancer patients compared with the microbiota of controls to reveal possible differences. A systematic review according to the PRISMA guidelines will be performed. The findings will be presented in narrative form as well as in tables and graphs. Full article
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