Supramolecular Hosts: Design and Applications

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Chemical Processes and Systems".

Deadline for manuscript submissions: closed (20 October 2023) | Viewed by 2862

Special Issue Editors


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Laboratoire COBRA (CNRS UMR 6014), I.R.C.O.F., Université de Rouen, 76821 Mont Saint Aignan, France
Interests: supramolecular chemistry; cyclodextrin; enzyme mimics; chemical decontamination; detoxification of organophosphorus compounds; bioorganic and medicinal chemistry

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UMR 6014 CNRS, Organic, BioOrganic, Analytical Chemistry and Reactivity, COBRA, University Rouen Normandy, IRCOF, Bat 40, 1, Rue Tesnière, 76821 Mont Saint Aignan, France
Interests: cyclodextrin; contrast agent; MRI imaging; theranostic; drug delivery; green chemistry; waters remediation
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Special Issue Information

Dear Colleagues,

Supramolecular hosts constitute a very attractive class of macrocycles with impacts in various fields: analytical chemistry, organic synthesis and catalysis, drugs targeting, medicinal/bioorganic/biological chemistry, enzyme mimics, polymer chemistry,  etc. Supramolecular hosts possess unique properties due to the ability to host guest molecules in their cavity. Thus, they afford a large panel of applications. Because of their multiple functionalization abilities, these compounds can be modified in order to face to many challenges. Many artificial receptors have therefore been developed for modulating their molecular recognition capabilities. All strategies based on the use of cavitands or others reveal the unmatched potential of these original structures to access new defined architectures. Supramolecular hosts are amongst the main classes of supramolecular organic host compounds, and constitute interesting platforms to obtain highlight results, especially in the field of interdisciplinary research projects.

This Special Issue on “Supramolecular Hosts: Design and Applications” is focused on recent advances in new developments and their applications. Topics include, but are not limited to:

  • Development of new catalysts for organic synthesis and industrial processes;
  • Biomedical uses and therapeutic strategies—imaging agents and drug carriers;
  • Medical devices;
  • Integration in green processes;
  • Analytical applications involving sensors and separation methods;
  • Nano- and biotechnologies—new materials and formulation processes;
  • Enzyme mimics—advances in bioorganic chemistry.

Prof. Dr. François Estour
Prof. Dr. Géraldine Gouhier
Guest Editors

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Keywords

  • supramolecular hosts
  • inclusion complexes
  • molecular recognition
  • supramolecular chemistry

Published Papers (2 papers)

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13 pages, 3083 KiB  
Article
Ternary Inclusion Complex of Sinapic Acid with Hydroxypropyl-β-cyclodextrin and Hydrophilic Polymer Prepared by Microwave Technology
by Abdul Ahad, Yousef A. Bin Jardan, Mohammad Raish, Abdullah M. Al-Mohizea and Fahad I. Al-Jenoobi
Processes 2022, 10(12), 2637; https://doi.org/10.3390/pr10122637 - 08 Dec 2022
Cited by 6 | Viewed by 1102
Abstract
Sinapic acid (SA) is a poorly water-soluble substance which could result in poor bioavailability. The aim of this study was to determine the “hydroxypropyl β-cyclodextrin (HPβCD)” solubilization of SA in the presence of the auxiliary substance hydroxypropyl methylcellulose (HPMC) and to evaluate the [...] Read more.
Sinapic acid (SA) is a poorly water-soluble substance which could result in poor bioavailability. The aim of this study was to determine the “hydroxypropyl β-cyclodextrin (HPβCD)” solubilization of SA in the presence of the auxiliary substance hydroxypropyl methylcellulose (HPMC) and to evaluate the ternary inclusion complex prepared by microwave technology. Phase-solubility profiles showed that HPβCD exhibited the greatest solubilizing effect on SA in the presence of HPMC. The enhanced rate of SA dissolution was exhibited by a ternary complex. Outcomes of analyses such as “DSC, FTIR, NMR, and SEM” confirmed the embedding of SA into the cavity of the HPβCD and the formation of a ternary inclusion complex. The outcomes of antioxidant activity (ABTS and nitric oxide scavenging activity) demonstrated that SA ternary inclusion complex (TIC) presented strong antioxidant activity, which might be a result of the enhanced solubility of SA in the TIC prepared by microwave technology. Hence, SA-TIC formulation could be a better dosage form which may protect the body from free radical damage and oxidative stress. Microwave technology greatly boosted the interaction of SA with HPβCD and HPMC, and such findings are expected to contribute to raising the solubility of SA, thereby improving the bioavailability of SA. Full article
(This article belongs to the Special Issue Supramolecular Hosts: Design and Applications)
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12 pages, 3438 KiB  
Article
Hydroxypropyl-β-Cyclodextrin for Delivery of Sinapic Acid via Inclusion Complex Prepared by Solvent Evaporation Method
by Abdul Ahad, Yousef A. Bin Jardan, Mohammad Raish, Abdullah M. Al-Mohizea and Fahad I. Al-Jenoobi
Processes 2022, 10(10), 2046; https://doi.org/10.3390/pr10102046 - 11 Oct 2022
Cited by 6 | Viewed by 1389
Abstract
The goal of this study was to increase the aqueous solubility and dissolution rate of sinapic acid (SA) by formulating binary inclusion complex (BIC) of SA with hydroxypropyl-β-cyclodextrin (HPβCD) using solvent evaporation (SE) technology. The phase solubility and dissolution studies were conducted to [...] Read more.
The goal of this study was to increase the aqueous solubility and dissolution rate of sinapic acid (SA) by formulating binary inclusion complex (BIC) of SA with hydroxypropyl-β-cyclodextrin (HPβCD) using solvent evaporation (SE) technology. The phase solubility and dissolution studies were conducted to determine the solubility and in vitro release rate of SA. In addition, the prepared inclusion complex was characterized for solid state characterization using techniques such as DSC, PXRD, SEM, and FTIR. Moreover, the prepared SA-BIC was evaluated for its antioxidant activity. Results revealed that the SA solubility can be shown to improve with a change in HPβCD concentration. About 2.59 times higher solubility of SA in water was noticed in the presence of HPβCD (10 mM). Dissolution study demonstrated that the 34.11 ± 4.51% of SA was released from binary physical mixture (BPM), while the maximum release of 46.27 ± 2.79% of SA was observed for SA-BIC prepared by SE method. The prepared SA-BIC demonstrated distinctive properties when compared to pure SA, which was demonstrated by different analytical methods, such as DSC, PXRD, SEM, and FTIR, as evidence of SA inclusion into HPβCD cavity. Further, it was observed that SA-BIC displayed stronger DPPH radical scavenging activity than SA. In conclusion, SE technology considerably enhanced the complexity of SA with HPβCD, and these observations could help to heighten the SA solubility, which may lead to a better bioavailability. Full article
(This article belongs to the Special Issue Supramolecular Hosts: Design and Applications)
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