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Polymers
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Advanced Biomass Macromolecules for Biomedical Applications
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Advanced Biomass Macromolecules for Biomedical Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Circular and Green Polymer Science".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 10029

Special Issue Editors

Dr. Xugang Dang

E-Mail Website
Guest Editor
Institute of Biomass and Function Materials & College of Bioresources Chemistry and Materials Engineering, Shaanxi University of Science and Technology, Xi'an, China
Interests: modification and functionalization of biomass macromolecules based on polysaccharide and gelatin; biomacromolecules for biomedical materials; new renewable biopolymers; resource utilization of biomass materials
Special Issues, Collections and Topics in MDPI journals
Dr. Caihong Wang

E-Mail Website
Guest Editor
College of Chemical Engineering, Sichuan University, Chengdu, China
Interests: exploration of smart materials based on thermoresponsive macromolecules; photoresponsive components towards renewable polymeric materials

Special Issue Information

Dear Colleagues,

In the development of polymer compounds, there is a strong need for replacing fossil-based products with biodegradable and/or natural bio-based ones. This replacement could resolve numerous issues, such as the reduction of oil stocks and their geographical localization, plastic pollution, carbon footprint and sustainability. The exploration and efficient utilization of natural biomass macromolecules is key to a sustainable future. Natural biomass macromolecules are the most abundant natural resource, and exhibit good properties (e.g., film-forming, biodegradability, biocompatibility). They have been widely applied in the food, pharmaceutical and agriculture industries. This Special Issue aims to focus on areas related to biomass macromolecule technologies, science, and functionalization, and their potential use in biomedical applications (e.g., antibacterial materials, drug carriers, tissue engineering). It will cover biomass macromolecules preparation, characterization, performance, and application evaluation. Potential topics include but are not limited to the research areas above.

Dr. Xugang Dang
Dr. Caihong Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomass macromolecules
  • polysaccharides
  • collagen and collagen hydrolysate
  • biocompatibility
  • biomedical application
  • biodegradability
  • biopolymers
  • multi-functionalization
  • resource utilization
  • structure–property relationships

Published Papers (5 papers)

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Research

12 pages, 15833 KiB  
Article
Chitosan Lactate Particles for Non-Compression Hemostasis on Hepatic Resection
by Yuhui Jiang, Xiaoxuan Tang, Tao Li, Jue Ling, Yifan Ge and Yumin Yang
Polymers 2023, 15(3), 656; https://doi.org/10.3390/polym15030656 - 27 Jan 2023
Cited by 1 | Viewed by 1409
Abstract
The liver is the most complex vascular anatomy of all human organs, with extremely rich blood flow and fragile texture. Massive liver bleeding usually occurs after traumatic liver injury, causing severe systematic issues. Thus, bleeding control is critical in hindering mortality rates and [...] Read more.
The liver is the most complex vascular anatomy of all human organs, with extremely rich blood flow and fragile texture. Massive liver bleeding usually occurs after traumatic liver injury, causing severe systematic issues. Thus, bleeding control is critical in hindering mortality rates and complications in patients. In this study, non-compression hemostasis materials based on chitosan lactate particles (CLP) were developed for handling liver bleeding after injuries. CLP showed good blood biocompatibility and antibacterial performance against S. aureus. Taking advantage of the vital capacity of CLP to promote red blood cell and platelet adhesion, CLP exhibited in vivo homeostasis properties as non-compression hemostasis materials for traumatic liver injury, both in SD rats, New Zealand rabbits, or in beagles. Whereas CLP has better hemostasis than the commercial hemostatic agent Celox™. Full article
(This article belongs to the Special Issue Advanced Biomass Macromolecules for Biomedical Applications)
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16 pages, 7988 KiB  
Article
Controlled Structure of Polyester/Hydroxyapatite Microparticles Fabricated via Pickering Emulsion Approach
by Nikita V. Minaev, Svetlana A. Minaeva, Anastasia A. Sherstneva, Tatiana V. Chernenok, Yulia K. Sedova, Ekaterina D. Minaeva, Vladimir I. Yusupov, Tatiana A. Akopova, Peter S. Timashev and Tatiana S. Demina
Polymers 2022, 14(20), 4309; https://doi.org/10.3390/polym14204309 - 13 Oct 2022
Cited by 1 | Viewed by 2201
Abstract
Biodegradable polyester/hydroxyapatite microparticles are widely proposed as microcarriers for drug/cell delivery or scaffolds for bone tissue regeneration. The current research implements the surfactant-free approach for the fabrication of polyester-based microparticles filled with hydroxyapatite nanoparticles (nHA) via the oil/water Pickering emulsion solvent evaporation technique [...] Read more.
Biodegradable polyester/hydroxyapatite microparticles are widely proposed as microcarriers for drug/cell delivery or scaffolds for bone tissue regeneration. The current research implements the surfactant-free approach for the fabrication of polyester-based microparticles filled with hydroxyapatite nanoparticles (nHA) via the oil/water Pickering emulsion solvent evaporation technique for the first time, to the best of our knowledge. The process of polyester microparticle fabrication using nHA for the oil/water interface stabilization was studied as a function of phase used for nHA addition, which allows the preparation of a range of microparticles either filled with nHA or having it as a shell over the polymeric core. The effect of processing conditions (polymer nature, polymer/nHA ratio, ultrasound treatment) on particles’ total yield, size distribution, surface and volume morphology, and chemical structure was analyzed using SEM, EDX, Raman spectroscopy, and mapping. Addition of nHA either within the aqueous or oil phase allowed the effective stabilization of the oil/water interface without additional molecular surfactants, giving rise to hybrid microparticles in which total yield, size distribution, and surface morphology depended on all studied processing conditions. Preliminary ultrasound treatment of any phase before the emulsification process led to a complex effect but did not affect the homogeneity of nHA distribution within the polymeric core of the hybrid microparticles. Full article
(This article belongs to the Special Issue Advanced Biomass Macromolecules for Biomedical Applications)
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17 pages, 4174 KiB  
Article
Stability of Biomimetically Functionalised Alginate Microspheres as 3D Support in Cell Cultures
by María Inmaculada García-Briega, Joaquín Ródenas-Rochina, Luis Amaro Martins, Senentxu Lanceros-Méndez, Gloria Gallego Ferrer, Amparo Sempere and José Luís Gómez Ribelles
Polymers 2022, 14(20), 4282; https://doi.org/10.3390/polym14204282 - 12 Oct 2022
Cited by 1 | Viewed by 2119
Abstract
Alginate hydrogels can be used to develop a three-dimensional environment in which various cell types can be grown. Cross-linking the alginate chains using reversible ionic bonds opens up great possibilities for the encapsulation and subsequent release of cells or drugs. However, alginate also [...] Read more.
Alginate hydrogels can be used to develop a three-dimensional environment in which various cell types can be grown. Cross-linking the alginate chains using reversible ionic bonds opens up great possibilities for the encapsulation and subsequent release of cells or drugs. However, alginate also has a drawback in that its structure is not very stable in a culture medium with cellular activity. This work explored the stability of alginate microspheres functionalised by grafting specific biomolecules onto their surface to form microgels in which biomimetic microspheres surrounded the cells in the culture, reproducing the natural microenvironment. A study was made of the stability of the microgel in different typical culture media and the formation of polyelectrolyte multilayers containing polylysine and heparin. Multiple myeloma cell proliferation in the culture was tested in a bioreactor under gentle agitation. Full article
(This article belongs to the Special Issue Advanced Biomass Macromolecules for Biomedical Applications)
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16 pages, 15617 KiB  
Article
Additive Manufacturing of Anatomical Poly(d,l-lactide) Scaffolds
by Dario Puppi, Gianni Pecorini and Gianluca Parrini
Polymers 2022, 14(19), 4057; https://doi.org/10.3390/polym14194057 - 27 Sep 2022
Cited by 1 | Viewed by 1652
Abstract
Poly(lactide) (PLA) is one of the most investigated semicrystalline polymers for material extrusion (MEX) additive manufacturing (AM) techniques based on polymer melt processing. Research on its application for the development of customized devices tailored to specific anatomical parts of the human body can [...] Read more.
Poly(lactide) (PLA) is one of the most investigated semicrystalline polymers for material extrusion (MEX) additive manufacturing (AM) techniques based on polymer melt processing. Research on its application for the development of customized devices tailored to specific anatomical parts of the human body can provide new personalized medicine strategies. This research activity was aimed at testing a new multifunctional AM system for the design and fabrication by MEX of anatomical and dog-bone-shaped PLA samples with different infill densities and deposition angles. In particular, a commercial PLA filament was employed to validate the computer-aided design (CAD) and manufacturing (CAM) process for the development of scaffold prototypes modeled on a human bone defect. Physical-chemical characterization of the obtained samples by 1H-NMR spectroscopy, size exclusion chromatography (SEC), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) demonstrated a small reduction of polymer molecular weight (~5%) due to thermal processing, as well as that the commercial polymer employed was a semicrystalline poly(d,l-lactide). Mechanical characterization highlighted the possibility of tuning elastic modulus and strength, as well as the elongation at break up to a 60% value by varying infill parameters. Full article
(This article belongs to the Special Issue Advanced Biomass Macromolecules for Biomedical Applications)
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14 pages, 3190 KiB  
Article
Self-Healable Covalently Adaptable Networks Based on Disulfide Exchange
by Xinru Guo, Feng Liu, Meng Lv, Fengbiao Chen, Fei Gao, Zhenhua Xiong, Xuejiao Chen, Liang Shen, Faman Lin and Xuelang Gao
Polymers 2022, 14(19), 3953; https://doi.org/10.3390/polym14193953 - 21 Sep 2022
Cited by 4 | Viewed by 2244
Abstract
Introducing dynamic covalent bonding into thermoset polymers has received considerable attention because they can repair or recover when damaged, thereby minimizing waste and extending the service life of thermoset polymers. However, most of the yielded dynamic covalent bonds require an extra catalyst, high [...] Read more.
Introducing dynamic covalent bonding into thermoset polymers has received considerable attention because they can repair or recover when damaged, thereby minimizing waste and extending the service life of thermoset polymers. However, most of the yielded dynamic covalent bonds require an extra catalyst, high temperature and high-pressure conditions to trigger their self-healing properties. Herein, we report on a catalyst-free bis-dynamic covalent polymer network containing vinylogous urethane and disulfide bonds. It is revealed that the introduction of disulfide bonds significantly reduces the activation energy (reduced from 94 kJ/mol to 51 kJ/mol) of the polymer system for exchanging and promotes the self-healing efficiency (with a high efficiency of 86.92% after being heated at 100 °C for 20 h) of the material. More importantly, the mechanical properties of the healed materials are comparable to those of the initial ones due to the special bis-dynamic covalent polymer network. These results suggest that the bis-dynamic covalent polymer network made of disulfide and inter-vinyl ester bonds opens a new strategy for developing high-performance vitrimer polymers. Full article
(This article belongs to the Special Issue Advanced Biomass Macromolecules for Biomedical Applications)
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