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Pharmaceutics
Special Issues
Pharmaceutics 2020 Young Investigators' Contributions Collection
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Pharmaceutics 2020 Young Investigators' Contributions Collection

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 3439

Special Issue Editors

Prof. Dr. Yvonne Perrie

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Guest Editor
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK
Interests: particulate systems and formulations for drug delivery; vaccine adjuvanticity and diagnostics
Special Issues, Collections and Topics in MDPI journals
Dr. Ana Sara Cordeiro

E-Mail Website
Guest Editor
Leicester Institute for Pharmaceutical Innovation, Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK
Interests: drug delivery; controlled release; nanomedicine; vaccine delivery; transdermal delivery; microneedles; diagnostics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pharmaceutics aims to compile the current trends and research directions of internationally renowned and successful young pharmaceutical scientists in one dedicated Special Issue. The idea for this Special Issue has arisen from the numerous and, above all, brilliant nominations for 2020 Young Investigator Award. It was the easiest-ever choice for us to publicly share the fascinating and thrilling research successes of the nominated scientists with you, our dear peer readers.

For this prestigious Special Issue, the journal Pharmaceutics will only accept original research papers that have been invited exclusively by the editors. The contributions to this Special Issue will highlight the current state-of-the-art in the fields of pharmaceutical formulation, process development, drug delivery, pharmacokinetics, biopharmaceutics, pharmacogenetics, and interdisciplinary research involving, but not limited to, engineering, biomedical sciences, and cell biology.

Please enjoy reading these high-end research highlights!

Prof. Dr. Yvonne Perrie
Dr. Ana Sara Cordeiro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

11 pages, 1107 KiB  
Article
Viscoelastic and Deformation Characteristics of Structurally Different Commercial Topical Systems
by Maryam Dabbaghi, Sarika Namjoshi, Bhavesh Panchal, Jeffrey E. Grice, Sangeeta Prakash, Michael Stephen Roberts and Yousuf Mohammed
Pharmaceutics 2021, 13(9), 1351; https://doi.org/10.3390/pharmaceutics13091351 - 27 Aug 2021
Cited by 25 | Viewed by 2638
Abstract
Rheological characteristics and shear response have potential implication in defining the pharmaceutical equivalence, therapeutic equivalence, and perceptive equivalence of commercial topical products. Three creams (C1 and C3 as oil-in-water and C2 as water-in-oil emulsions), and two gels (G1 and G2 carbomer-based) were characterized [...] Read more.
Rheological characteristics and shear response have potential implication in defining the pharmaceutical equivalence, therapeutic equivalence, and perceptive equivalence of commercial topical products. Three creams (C1 and C3 as oil-in-water and C2 as water-in-oil emulsions), and two gels (G1 and G2 carbomer-based) were characterized using the dynamic range of controlled shear in steady-state flow and oscillatory modes. All products, other than C3, met the Critical Quality Attribute criteria for high zero-shear viscosity (η0) of 2.6 × 104 to 1.5 × 105 Pa∙s and yield stress (τ0) of 55 to 277 Pa. C3 exhibited a smaller linear viscoelastic region and lower η0 (2547 Pa∙s) and τ0 (2 Pa), consistent with lotion-like behavior. All dose forms showed viscoelastic solid behavior having a storage modulus (G′) higher than the loss modulus (G″) in the linear viscoelastic region. However, the transition of G′ > G″ to G″ > G′ during the continual strain increment was more rapid for the creams, elucidating a relatively brittle deformation, whereas these transitions in gels were more prolonged, consistent with a gradual disentanglement of the polymer network. In conclusion, these analyses not only ensure quality and stability, but also enable the microstructure to be characterized as being flexible (gels) or inelastic (creams). Full article
(This article belongs to the Special Issue Pharmaceutics 2020 Young Investigators' Contributions Collection)
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