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Special Issue "Impact of Physicochemical Properties of Pharmaceutical Substances on Dosage Form Performance"
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 32567
Special Issue Editors
Interests: new drug carriers (ordered mesoporous silica and electro-spun biodegradable polymer materials); preformulation and drug dissolution/release; manufacturing process of solid dosage forms
Interests: anti-crystal engineering (ionic liquids and eutectic forms of drugs); multicomponent and liquid crystals; amorphous pharmaceutical system; poorly soluble drugs
Interests: chromatographic techniques in materials characterisation
Interests: solid state of pharmaceuticals; amorphous pharmaceutical systems; multicomponent pharmaceutical systems; poorly soluble drugs; preformulation
Special Issue Information
The physicochemical properties of an active pharmaceutical ingredient (API) and/or an excipient may affect the development of a dosage form, regardless of its type and route of administration, and influence its performance. For instance, a success in the design of semi-solid dosage formulation is largely determined on understanding the physicochemical factors (e.g., solubility, partition coefficient) that modulate bioavailability, while in the case of solid oral dosage forms, poor solubility and low dissolution rates often lead to poor bioavailability. There are many approaches that could be used to improve drug solubility and dissolution rates, e.g., chemical modification of APIs, solid state alteration, the use of excipients (surfactants, cyclodextrins or polymers) or manipulation of particle size. The solid form, the particle size and shape of an API or excipient may have a significant impact on the properties of the final dosage form. When a therapeutically active molecule is under development, it is crucial that it is produced it in a desired form in a consistent, pure and reproducible manner. Furthermore, during the formulation process, the API can undergo physical and/or chemical changes. Despite a wide variety of analytical techniques available to characterise APIs, such as thermal analysis, spectroscopy and others, the structural characterisation of subtle differences between different solid-state forms (for example amorphous forms) of API continues to be a challenge. The physicochemical properties of a solid pharmaceutical substance are strongly related not only to its structural features but also to its molecular dynamics. Thus, it is important to understand not only the structure but also the dynamic of molecular motion occurring in a drug substance because molecular relaxation may take place during storage of the formulated drug. Therefore, a thorough knowledge of the solid-state behaviour of a pharmaceutical substance is essential for reliable drug product manufacturing.
This Special Issue welcomes contributions demonstrating the impact of physicochemical properties of pharmaceutical substances on dosage form performance. It aims at presenting the current status of the field and highlighting the prospects of this area of pharmaceutical sciences. As the topic is very relevant to the industrial drug product development process, we encourage submissions emerging from co-operation between academia and pharmaceutical industry.
Prof. Dr. Janina Lulek
Dr. Lidia Tajber
Prof. Dr. Adam Voelkel
Dr. Marcin Skotnicki
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- active pharmaceutical ingredient
- solid state form
- particle size and shape
- chemical and physical stability
- solubility/dissolution rate