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Pharmaceutics
Special Issues
Polymeric Nanomicelles as Advanced Carriers for Drug Products
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Polymeric Nanomicelles as Advanced Carriers for Drug Products

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 11032

Special Issue Editors

Dr. Junzi Wu

E-Mail Website
Guest Editor
The Key Laboratory of Microcosmic Syndrome Differentiation, College of Basic Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China
Interests: polymer; drug delivery; nanomicelles; nanocarriers; controlled release systems; synthesis, characterization, and applications of nanoparticles; tumor targeting; diabetes sustained-release material; temperature-sensitive material
Dr. Yu Luo

E-Mail Website
Guest Editor
The Department of pharmacy, School of Chemistry and Chemical Engineering,Shanghai University of Engingeering Science, Shanghai 201620 ,China
Interests: biomaterials; nanomedicine; tumor therapy; immunotherapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Polymeric nanomicelles have received significant attention for drug delivery, and they have been extensively studied in various diseases such as cancer, diabetes, and brain diseases. In addition, the methods of administration are also diversified, such as nasal administration, intravenous injection, subcutaneous injection, oral administration, and skin administration. These determine the final polymeric nanomicelles’ performances as advanced carriers for drug products.

This Special Issue will cover different areas of polymeric nanomicelles as a means to control or modify the release of drug substances from drug delivery systems. Contributions to this Special Issue can be original research or review articles and may cover all aspects of polymeric nanomicelles, ranging from design to production and characterization from both technological and a biological points of view for the correct use of such polymeric nanomicelles as drug carriers.

We would like to thank in advance all authors who take time out of their busy schedules to contribute to this Special Issue of Pharmaceutics.

Dr. Junzi Wu
Dr. Yu Luo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymeric nanomicelles 
  • smart nanomicelles 
  • drug delivery 
  • self-assembled nanomicelles 
  • systemic drug delivery 
  • tumor-targeted drug delivery 
  • controlled release 
  • drug carriers 
  • particulate delivery systems 
  • biopolymers 
  • nanoparticles 
  • natural polymer polysaccharide

Published Papers (5 papers)

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Research

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15 pages, 29681 KiB  
Article
PLGA Nanoparticles Loaded with Sorafenib Combined with Thermosensitive Hydrogel System and Microwave Hyperthermia for Multiple Sensitized Radiotherapy
by Ziqi Wang, Bo Liu, Jingyao Tu, Jingfeng Xiang, Hui Xiong, Yue Wu, Shuaijie Ding, Daoming Zhu, Dongyong Zhu, Fei Liu, Guangyuan Hu and Xianglin Yuan
Pharmaceutics 2023, 15(2), 487; https://doi.org/10.3390/pharmaceutics15020487 - 01 Feb 2023
Cited by 1 | Viewed by 1505
Abstract
Hypoxia is typically the leading cause of radiotherapy (RT) resistance in solid tumors, and glutathione (GSH) overexpression in tumor cells is a potent antioxidant mechanism that protects tumor cells from radiation damage. Herein, we developed a sorafenib (SFN) loaded-PLGA hydrogel system (SPH) in [...] Read more.
Hypoxia is typically the leading cause of radiotherapy (RT) resistance in solid tumors, and glutathione (GSH) overexpression in tumor cells is a potent antioxidant mechanism that protects tumor cells from radiation damage. Herein, we developed a sorafenib (SFN) loaded-PLGA hydrogel system (SPH) in combination with microwave (MW) hyperthermia for RT sensitization. SPH with stable properties was produced by combining SFN and PLGA in a specific ratio and encapsulating the mixture in agarose hydrogel. Intratumoral injection of SPH to mice combined with MW hyperthermia can not only directly cause thermal damage to tumor cells, but also increase blood oxygen delivery to the tumor site, thus overcoming the problem of intratumoral hypoxia and achieving “first layer” RT sensitization. Moreover, high temperatures can cause the hydrogel to disintegrate and release SFN. Not only can SFN inhibit tumor growth, but it can also achieve the “second layer” of RT sensitization by inhibiting glutathione (GSH) synthesis in cells and increasing reactive oxygen species (ROS) production. Experiments, both in vitro and in vivo, have indicated that SPH and MW hyperthermia can achieve a double RT sensitization effect and a significant tumor inhibition effect. In conclusion, combining our SPH nanosystem and thermoradiotherapy is a promising anti-tumor treatment. Full article
(This article belongs to the Special Issue Polymeric Nanomicelles as Advanced Carriers for Drug Products)
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16 pages, 4493 KiB  
Article
Polymeric Nanomicelles Loaded with Anandamide and Their Renal Effects as a Therapeutic Alternative for Hypertension Treatment by Passive Targeting
by Virna Margarita Martín Giménez, Marcela Analía Moretton, Diego Andrés Chiappetta, María Jimena Salgueiro, Miguel Walter Fornés and Walter Manucha
Pharmaceutics 2023, 15(1), 176; https://doi.org/10.3390/pharmaceutics15010176 - 03 Jan 2023
Cited by 1 | Viewed by 1224
Abstract
We have previously demonstrated significant in vitro natriuretic effects of anandamide (AEA) nanoformulation in polymeric nanoparticles, whose size prevents their accumulation in organs, such as the kidneys. Therefore, it is of particular interest to design and test nanostructures that can pharmacologically accumulate in [...] Read more.
We have previously demonstrated significant in vitro natriuretic effects of anandamide (AEA) nanoformulation in polymeric nanoparticles, whose size prevents their accumulation in organs, such as the kidneys. Therefore, it is of particular interest to design and test nanostructures that can pharmacologically accumulate in these organs. In this regard, we prepared and characterized polymeric nanomicelles (~14 and 40 nm). Likewise, their biodistribution was determined. Spontaneously hypertensive rats (SHR) and normotensive rats (WKY), n = 3 per group, were divided into five treatment conditions: control, sham, free AEA freshly dispersed in aqueous solution or 24 h after its dispersion, and AEA encapsulated in nanomicelles. The kidneys were the main site of accumulation of the nanoformulation after 24 h. Freshly dispersed free AEA showed its classical triphasic response in SHR, which was absent from all other treatments. Nanoformulated AEA produced a sustained antihypertensive effect over 2 h, accompanied by a significant increase in fractional sodium excretion (FSE %). These effects were not observed in WKY, sham, or free AEA-treated rats after 24 h of its aqueous dispersion. Without precedent, we demonstrate in vivo natriuretic, diuretic, and hypotensive effects of AEA nanoformulation in polymeric nanomicelles, suggesting its possible use as a new antihypertensive agent with intravenous administration and passive renal accumulation. Full article
(This article belongs to the Special Issue Polymeric Nanomicelles as Advanced Carriers for Drug Products)
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9 pages, 1399 KiB  
Communication
A Cationic Amphiphilic AIE Polymer for Mitochondrial Targeting and Imaging
by Junliang Zhou, Haiyang Wang, Wen Wang, Zhiwei Ma, Zhenguo Chi and Siwei Liu
Pharmaceutics 2023, 15(1), 103; https://doi.org/10.3390/pharmaceutics15010103 - 28 Dec 2022
Cited by 4 | Viewed by 1315
Abstract
Mitochondria are important organelles that play key roles in generating the energy needed for life and in pathways such as apoptosis. Direct targeting of antitumor drugs, such as doxorubicin (DOX), to mitochondria into cells is an effective approach for cancer therapy and inducing [...] Read more.
Mitochondria are important organelles that play key roles in generating the energy needed for life and in pathways such as apoptosis. Direct targeting of antitumor drugs, such as doxorubicin (DOX), to mitochondria into cells is an effective approach for cancer therapy and inducing cancer cell death. To achieve targeted and effective delivery of antitumor drugs to tumor cells, to enhance the therapeutic effect, and to reduce the side effects during the treatment, we prepared a cationic amphiphilic polymer with aggregation-induced emission (AIE) characteristic. The polymer could be localized to mitochondria with excellent organelle targeting, and it showed good mitochondrial targeting with low toxicity. The polymer could also self-assemble into doxorubicin-loaded micelles in phosphate buffer, with a particle size of about 4.3 nm, an encapsulation rate of 11.03%, and micelle drug loading that reached 0.49%. The results of in vitro cytotoxicity experiments showed that the optimal dosage was 2.0 μg/mL, which had better inhibitory effect on tumor cells and less biological toxicity on heathy cells. Therefore, the cationic amphiphilic polymer can partially replace expensive commercial mitochondrial targeting reagents, and it can be also used as a drug loading tool to directly target mitochondria in cells for corresponding therapeutic research. Full article
(This article belongs to the Special Issue Polymeric Nanomicelles as Advanced Carriers for Drug Products)
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Review

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24 pages, 4543 KiB  
Review
Research Progress on Stimulus-Responsive Polymer Nanocarriers for Cancer Treatment
by Shicui Luo, Zhuo Lv, Qiuqiong Yang, Renjie Chang and Junzi Wu
Pharmaceutics 2023, 15(7), 1928; https://doi.org/10.3390/pharmaceutics15071928 - 11 Jul 2023
Cited by 8 | Viewed by 1448
Abstract
As drug carriers for cancer treatment, stimulus-responsive polymer nanomaterials are a major research focus. These nanocarriers respond to specific stimulus signals (e.g., pH, redox, hypoxia, enzymes, temperature, and light) to precisely control drug release, thereby improving drug uptake rates in cancer cells and [...] Read more.
As drug carriers for cancer treatment, stimulus-responsive polymer nanomaterials are a major research focus. These nanocarriers respond to specific stimulus signals (e.g., pH, redox, hypoxia, enzymes, temperature, and light) to precisely control drug release, thereby improving drug uptake rates in cancer cells and reducing drug damage to normal cells. Therefore, we reviewed the research progress in the past 6 years and the mechanisms underpinning single and multiple stimulus-responsive polymer nanocarriers in tumour therapy. The advantages and disadvantages of various stimulus-responsive polymeric nanomaterials are summarised, and the future outlook is provided to provide a scientific and theoretical rationale for further research, development, and utilisation of stimulus-responsive nanocarriers. Full article
(This article belongs to the Special Issue Polymeric Nanomicelles as Advanced Carriers for Drug Products)
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21 pages, 1985 KiB  
Review
Current Progress and Outlook of Nano-Based Hydrogel Dressings for Wound Healing
by Xiao Zhang, Pengyu Wei, Zhengyang Yang, Yishan Liu, Kairui Yang, Yuhao Cheng, Hongwei Yao and Zhongtao Zhang
Pharmaceutics 2023, 15(1), 68; https://doi.org/10.3390/pharmaceutics15010068 - 26 Dec 2022
Cited by 17 | Viewed by 3804
Abstract
Wound dressing is an important tool for wound management. Designing wound dressings by combining various novel materials and drugs to optimize the peri-wound environment and promote wound healing is a novel concept. Hydrogels feature good ductility, high water content, and favorable oxygen transport, [...] Read more.
Wound dressing is an important tool for wound management. Designing wound dressings by combining various novel materials and drugs to optimize the peri-wound environment and promote wound healing is a novel concept. Hydrogels feature good ductility, high water content, and favorable oxygen transport, which makes them become some of the most promising materials for wound dressings. In addition, nanomaterials exhibit superior biodegradability, biocompatibility, and colloidal stability in wound healing and can play a role in promoting healing through their nanoscale properties or as carriers of other drugs. By combining the advantages of both technologies, several outstanding and efficient wound dressings have been developed. In this paper, we classify nano-based hydrogel dressings into four categories: hydrogel dressings loaded with a nanoantibacterial drug; hydrogel dressings loaded with oxygen-delivering nanomedicines; hydrogel dressings loaded with nanonucleic acid drugs; and hydrogel dressings loaded with other nanodelivered drugs. The design ideas, advantages, and challenges of these nano-based hydrogel wound dressings are reviewed and analyzed. Finally, we envisaged possible future directions for wound dressings in the context of relevant scientific and technological advances, which we hope will inform further research in wound management. Full article
(This article belongs to the Special Issue Polymeric Nanomicelles as Advanced Carriers for Drug Products)
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