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Pharmaceutics
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Liquid Crystalline Drug Delivery Systems Applicable in Different Routes of...
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Liquid Crystalline Drug Delivery Systems Applicable in Different Routes of Administration

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 8569

Special Issue Editors

Dr. Marlus Chorilli

E-Mail Website
Guest Editor
Department of Drugs and Medicines, São Paulo State University—UNESP, Rodovia Araraquara Jaú, Km 1, Araraquara 14800-903, SP, Brazil
Interests: lipid-based carriers; drug delivery systems; in vivo assays; clinical assays
Special Issues, Collections and Topics in MDPI journals
Dr. Marcela Tavares Luiz

E-Mail Website
Guest Editor
Department of Drugs and Medicines, São Paulo State University—UNESP, Rodovia Araraquara Jaú, Km. 1, Araraquara 14800-903, SP, Brazil
Interests: polymeric nanocapsules; hybrid nanoparticles; cyclic anhydride copolymers; hydrogels; controlled and targeted drug delivery; in vitro biological testing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Liquid crystals (LCs) have generated great interest as drug delivery systems, designed with the physical properties of liquids but capable of retaining some structural characteristics of crystalline solids. The use of LCs as drug delivery systems has demonstrated great potential due to their ability to encapsulate lipophilic and hydrophilic drugs, protect drugs against degradation and improve drug permeation through biological barriers. Taking into account that the development of LCs can contribute to the delivery of drugs via several routes of administration, we would like to invite you to contribute with a short communication, research or review article to this Special Issue, entitled “Liquid Crystalline Drug Delivery Systems Applicable in Different Routes of Administration”. This Special Issue aims to highlight the current progress in the development of LCs for drug delivery.

Dr. Marlus Chorilli
Dr. Marcela Tavares Luiz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liquid crystalline systems
  • drug delivery systems
  • lamellar
  • cubic
  • hexagonal

Published Papers (3 papers)

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Research

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16 pages, 2214 KiB  
Article
Bicontinuous Cubic Liquid Crystals as Potential Matrices for Non-Invasive Topical Sampling of Low-Molecular-Weight Biomarkers
by Maxim Morin, Sebastian Björklund, Emelie J. Nilsson and Johan Engblom
Pharmaceutics 2023, 15(8), 2031; https://doi.org/10.3390/pharmaceutics15082031 - 28 Jul 2023
Viewed by 974
Abstract
Many skin disorders, including cancer, have inflammatory components. The non-invasive detection of related biomarkers could therefore be highly valuable for both diagnosis and follow up on the effect of treatment. This study targets the extraction of tryptophan (Trp) and its metabolite kynurenine (Kyn), [...] Read more.
Many skin disorders, including cancer, have inflammatory components. The non-invasive detection of related biomarkers could therefore be highly valuable for both diagnosis and follow up on the effect of treatment. This study targets the extraction of tryptophan (Trp) and its metabolite kynurenine (Kyn), two compounds associated with several inflammatory skin disorders. We furthermore hypothesize that lipid-based bicontinuous cubic liquid crystals could be efficient extraction matrices. They comprise a large interfacial area separating interconnected polar and apolar domains, allowing them to accommodate solutes with various properties. We concluded, using the extensively studied GMO-water system as test-platform, that the hydrophilic Kyn and Trp favored the cubic phase over water and revealed a preference for locating at the lipid–water interface. The interfacial area per unit volume of the matrix, as well as the incorporation of ionic molecules at the lipid–water interface, can be used to optimize the extraction of solutes with specific physicochemical characteristics. We also observed that the cubic phases formed at rather extreme water activities (>0.9) and that wearing them resulted in efficient hydration and increased permeability of the skin. Evidently, bicontinuous cubic liquid crystals constitute a promising and versatile platform for non-invasive extraction of biomarkers through skin, as well as for transdermal drug delivery. Full article
(This article belongs to the Special Issue Liquid Crystalline Drug Delivery Systems Applicable in Different Routes of Administration)
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Review

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26 pages, 1972 KiB  
Review
Recent Advances in the Development of Liquid Crystalline Nanoparticles as Drug Delivery Systems
by Jassica S. L. Leu, Jasy J. X. Teoh, Angel L. Q. Ling, Joey Chong, Yan Shan Loo, Intan Diana Mat Azmi, Noor Idayu Zahid, Rajendran J. C. Bose and Thiagarajan Madheswaran
Pharmaceutics 2023, 15(5), 1421; https://doi.org/10.3390/pharmaceutics15051421 - 06 May 2023
Cited by 5 | Viewed by 3107
Abstract
Due to their distinctive structural features, lyotropic nonlamellar liquid crystalline nanoparticles (LCNPs), such as cubosomes and hexosomes, are considered effective drug delivery systems. Cubosomes have a lipid bilayer that makes a membrane lattice with two water channels that are intertwined. Hexosomes are inverse [...] Read more.
Due to their distinctive structural features, lyotropic nonlamellar liquid crystalline nanoparticles (LCNPs), such as cubosomes and hexosomes, are considered effective drug delivery systems. Cubosomes have a lipid bilayer that makes a membrane lattice with two water channels that are intertwined. Hexosomes are inverse hexagonal phases made of an infinite number of hexagonal lattices that are tightly connected with water channels. These nanostructures are often stabilized by surfactants. The structure’s membrane has a much larger surface area than that of other lipid nanoparticles, which makes it possible to load therapeutic molecules. In addition, the composition of mesophases can be modified by pore diameters, thus influencing drug release. Much research has been conducted in recent years to improve their preparation and characterization, as well as to control drug release and improve the efficacy of loaded bioactive chemicals. This article reviews current advances in LCNP technology that permit their application, as well as design ideas for revolutionary biomedical applications. Furthermore, we have provided a summary of the application of LCNPs based on the administration routes, including the pharmacokinetic modulation property. Full article
(This article belongs to the Special Issue Liquid Crystalline Drug Delivery Systems Applicable in Different Routes of Administration)
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29 pages, 1068 KiB  
Review
New Technological Approaches for Dental Caries Treatment: From Liquid Crystalline Systems to Nanocarriers
by Marcela Tavares Luiz, Leonardo Delello di Filippo, Jessyca Aparecida Paes Dutra, Juliana Santos Rosa Viegas, Amanda Letícia Polli Silvestre, Caroline Anselmi, Jonatas Lobato Duarte, Giovana Maria Fioramonti Calixto and Marlus Chorilli
Pharmaceutics 2023, 15(3), 762; https://doi.org/10.3390/pharmaceutics15030762 - 24 Feb 2023
Cited by 7 | Viewed by 4085
Abstract
Dental caries is the most common oral disease, with high prevalence rates in adolescents and low-income and lower-middle-income countries. This disease originates from acid production by bacteria, leading to demineralization of the dental enamel and the formation of cavities. The treatment of caries [...] Read more.
Dental caries is the most common oral disease, with high prevalence rates in adolescents and low-income and lower-middle-income countries. This disease originates from acid production by bacteria, leading to demineralization of the dental enamel and the formation of cavities. The treatment of caries remains a global challenge and the development of effective drug delivery systems is a potential strategy. In this context, different drug delivery systems have been investigated to remove oral biofilms and remineralize dental enamel. For a successful application of these systems, it is necessary that they remain adhered to the surfaces of the teeth to allow enough time for the removal of biofilms and enamel remineralization, thus, the use of mucoadhesive systems is highly encouraged. Among the systems used for this purpose, liquid crystalline systems, polymer-based nanoparticles, lipid-based nanoparticles, and inorganic nanoparticles have demonstrated great potential for preventing and treating dental caries through their own antimicrobial and remineralization properties or through delivering drugs. Therefore, the present review addresses the main drug delivery systems investigated in the treatment and prevention of dental caries. Full article
(This article belongs to the Special Issue Liquid Crystalline Drug Delivery Systems Applicable in Different Routes of Administration)
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