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Dear Colleagues,

The designer of drug delivery system with mucoadhesive properties has grown exponentially due to its adjustable characteristics, such as the high ability to prolong the residence time of the preparation at the site of action or absorption, intensifying the drug's contact with the epithelial barrier of the skin or mucosa; ability to increase the residence time of the pharmaceutical preparation at the site of action, combined with a controlled release, in addition, it may favor the maintenance of the effective concentration at the site of action or absorption and the control of drug release, which may, increase therapeutic efficiency and reduce the dose and frequency of drug administration. However, before developing systems with mucoadhesive properties, it is important to know the composition of the mucus, the materials with mucoadhesive properties, and the mechanisms of mucoadhesion. Taking into account the relevance and timely contribution of mucoadhesive properties for efficient drug delivery via several routes of administration, we would like to invite you to participate by proposing short communication, original and review papers on this issue: “(Bio)mucoadhesive Drug Delivery Systems”. This special edition of Pharmaceutics deals with new strategies to design and apply any type of drug delivery system with mucoadhesive properties.

Dr. Marlus Chorilli
Prof. Dr. Bruno Fonseca-Santos
Dr. Suzana Gonçalves Carvalho
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Keywords

mucoadhesive
drug delivery systems
in vivo assays
in vitro assays

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14 pages, 1738 KiB

Open AccessArticle

Design and Characterization of Lipid-Surfactant-Based Systems for Enhancing Topical Anti-Inflammatory Activity of Ursolic Acid

by Bruno Fonseca-Santos, Giovanna Angeli Araujo, Paula Scanavez Ferreira, Francesca Damiani Victorelli, Andressa Maria Pironi, Victor Hugo Sousa Araújo, Suzana Gonçalves Carvalho and Marlus Chorilli

Pharmaceutics 2023, 15(2), 366; https://doi.org/10.3390/pharmaceutics15020366 - 21 Jan 2023

Cited by 7 | Viewed by 1503

Abstract

Skin inflammation is a symptom of many skin diseases, such as eczema, psoriasis, and dermatitis, which cause rashes, redness, heat, or blistering. The use of natural products with anti-inflammatory properties has gained importance in treating these symptoms. Ursolic acid (UA), a promising natural compound that is used to treat skin diseases, exhibits low aqueous solubility, resulting in poor absorption and low bioavailability. Designing topical formulations focuses on providing adequate delivery via application to the skin surface. The aim of this study was to formulate and characterize lipid-surfactant-based systems for the delivery of UA. Microemulsions and liquid crystalline systems (LCs) were characterized by polarized light microscopy (PLM), rheology techniques, and textural and bioadhesive assays. PLM supported the self-assembly of these systems and elucidated their formation. Rheologic examination revealed pseudoplastic and thixotropic behavior appropriate, and assays confirmed the ability of these formulations to adhere to the skin. In vivo studies were performed, and inflammation induced by croton oil was assessed for response to microemulsions and LCs. UA anti-inflammatory activities of ~60% and 50% were demonstrated by two microemulsions and 40% and 35% by two LCs, respectively. These data support the continued development of colloidal systems to deliver UA to ameliorate skin inflammation. Full article

(This article belongs to the Special Issue (Bio)mucoadhesive Drug Delivery Systems)

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